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Part of the book series: Evidenzbasierte Chirurgie ((EC))

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Zusammenfassung

Gastrointestinale Stromatumoren sind sehr seltene Tumoren, die zur chirurgischen Therapie vorliegende Evidenz ist insgesamt wenig umfangreich. Gleichwohl stellt die Chirurgie bei primär resektablen Befunden die wichtigste Therapiemodalität dar. Organ- und funktionserhaltende Verfahren stehen im Vordergrund. Laparoskopische Resektionen sind, insbesondere bei kleineren Tumoren des Magens, sicher durchführbar. Bei lokal fortgeschrittenen Befunden kann eine neoadjuvante Therapie mit Imatinib durch eine Tumorverkleinerung das notwendige Resektionsausmaß reduzieren oder eine vollständige Tumorresektion überhaupt erst möglich machen. Bei rezidivierten oder metastasierten GIST kann eine Tumorresektion erwogen werden, wenn hierdurch nach medikamentöser Tumorkontrolle Tumorfreiheit zu erreichen ist oder ein unter Tyrosinkinaseinhibitor (TKI)-Therapie progredienter Herd bei ansonsten stabiler Erkrankung (fokale Progression) behandelt werden soll. Weitere prospektive Studien sind nötig, um den Stellenwert der Chirurgie in unterschiedlichen Behandlungssituationen zu definieren.

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Albertsmeier, M., Werner, J. (2018). Gastrointestinale Stromatumoren. In: Germer, CT., Keck, T., Grundmann, R.T. (eds) Evidenzbasierte Viszeralchirurgie maligner Erkrankungen. Evidenzbasierte Chirurgie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-56533-9_4

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  • DOI: https://doi.org/10.1007/978-3-662-56533-9_4

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