Surface Enhanced Raman Spectroscopy for Medical Diagnostics

  • Izabella J. Jahn
  • Andreea I. Radu
  • Karina Weber
  • Dana Cialla-May
  • Juergen PoppEmail author


Medical diagnosis requires reliable identification of very low concentration of different biomarkers specific for medical conditions in a time-effective manner. In this chapter, we summarize the work reported on the application of surface-enhanced Raman spectroscopy for the detection and the identification of different biomarkers in body fluids, tissues, or in vivo.

List of Abbreviations




4-Mercaptobenzoic acid


Ascorbic acid


Alzheimer’s disease


Atomic force microscopy




Advanced gastric cancer




Telomeric repeat complementary oligonucleotide


Gold film-over-nanospheres

Amyloid β


Bovine serum albumin


Chlorin e6


Carcinoembryonic antigen


Continuous glucose monitoring


Creatine kinase MB


2-Cyano-2-propyl benzodithioate


Cerebrospinal fluid


Troponin I


Troponin T


Cardiovascular diseases


Cyanine 5


Deoxyribonucleic acid




5,5-Dithiobis(2-dinitrobenzoic acid)


Diethylthiatricarbocyanine iodide


Electron beam lithography






Clarke error grid analysis


Early gastric cancer


Epidermal growth factor receptor


Enzyme-linked immunosorbent assay


Gram negative


Gram positive


Glucose oxidase


Hepatitis B virus antigen


Hollow core photonic crystal fiber


Human cervical cells


2-Hydroxyethyl methacrylate


Human epidermal growth factor receptor 2


Human immunodeficiency virus


High-performance liquid chromatography


Human papillomavirus


Immunoglobulin G


Inverse molecular sentinel


International Organization Standard


Indium tin oxide


Lipoic acid


Lab-on-a-chip SERS


Limit of detection


Magnetic nanobeads


Malachite green isothiocyanate




Myocardial infarction


Micro ribonucleic acid 21


Micro ribonucleic acid


Magnetic nanoparticle


Mercaptophenylboronic acid


O-[2-(3-Mercaptopropionylamino)ethyl]-O′-methylpolyethylene glycol




Magnetic resonance imaging


Messenger ribonucleic acid


Mycobacterium tuberculosis complex




11-Mercaptoundecanoic acid










Oblique angle deposition


Oral squamous carcinoma


Phosphate-buffered saline


Phosphate-buffered saline tween-20


Principal component analysis


Zwitterionic poly(carboxybetaine acrylamide)




Polymerase chain reaction


Polyethylene glycol


Thiolated PEG


Positron emission tomography


Partial least squares discriminant analysis


Red blood cells


Rhodamine 6 G


Standard addition method


Surface-enhanced resonance Raman spectroscopy


Surface-enhanced Raman spectroscopy


Surface-enhanced spatially offset Raman spectroscopy


Turnaround time


Transforming growth factor beta receptor II


3,3′,5, 5′-Tetramethylbenzidine


Thiopurine s-methyltransferase


Telomeres substrate




Vascular endothelial growth factor


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Izabella J. Jahn
    • 3
  • Andreea I. Radu
    • 3
  • Karina Weber
    • 4
  • Dana Cialla-May
    • 4
  • Juergen Popp
    • 1
    • 2
    Email author
  1. 1.Institute of Photonic TechnologyJenaGermany
  2. 2.Institute of Physical Chemistry and Abbe Center of PhotonicsJenaGermany
  3. 3.Leibniz Institute of Photonic Technology JenaJenaGermany
  4. 4.Friedrich Schiller University Jena, Institute of Physical Chemistry and Abbe Center of PhotonicsJenaGermany

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