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GMO sapiens heute und morgen

  • Paul Knoepfler
Chapter
  • 2k Downloads

Zusammenfassung

Im‌ Jahr 2014 beugte sich ein Wissenschaftler in Dr. Junjiu Huangs Labor an der Sun-Yat-sen-Universität im chinesischen Guangdong über ein Mikroskop und betrachtete einzellige menschliche Embryonen in einer Petrischale. Im Licht des Mikroskops sahen sie wie winzige durchscheinende Kugeln aus. Der Wissenschaftler stach mit einer sehr dünnen, scharfen Nadel in den ersten dieser Embryonen.

Literatur

  1. Araki M, Ishii T (2014) International regulatory landscape and integration of corrective genome editing into in vitro fertilization. Reprod Biol Endocrinol 12:108CrossRefGoogle Scholar
  2. Baltimore D, Berg P (2015) Let’s hit „pause“ before altering humankind. The Wall Street Journal, 8 April 2015. https://www.wsj.com/articles/lets-hit-pause-before-altering-humankind-1428536400. Zugegriffen am 12.06.2017
  3. Baltimore D, Berg P, Botchan M, Carroll D, Charo RA, Church G, Corn JE, Daley GQ, Doudna JA, Fenner M, Greely HT, Jinek M, Martin GS, Penhoet E, Puck J, Sternberg SH, Weissman JS, Yamamoto KR (2015) A prudent path forward for genomic engineering and germline gene modification. Science 348(6230):36–38CrossRefGoogle Scholar
  4. Center for Genetics and Society (2015) Genetically modified humans? Seven reasons to say „No“, 7 Mai 2015. https://www.geneticsandsociety.org/biopolitical-times/genetically-modified-humans-seven-reasons-say-no. Zugegriffen am 29.08.2017
  5. Church GM (2016) List of personal genome sequencing and interpretation services. http://arep.med.harvard.edu/gmc/genome_services.html. Stand: 12.11.2016. Zugegriffen am 12.06.2017
  6. Cyranoski D (2015) Ethics of embryo editing divides scientists. Nature 519:272.  https://doi.org/10.1038/519272a. (19 March 2015)CrossRefGoogle Scholar
  7. Cyranoski D, Reardon S (2015) Chinese scientists genetically modify human embryos. Nature news. http://www.nature.com/news/chinese-scientists-genetically-modify-human-embryos-1.17378?WT.mc_id=TWT_NatureNews. Zugegriffen am 12.06.2017
  8. Deonandan R, Green S, van Beinum A (2012) Ethical concerns for maternal surrogacy and reproductive tourism. J Med Ethics 38(12):742–745CrossRefGoogle Scholar
  9. Greely H (2015) Of Science, CRISPR-Cas9, and Asilomar. https://law.stanford.edu/2015/04/04/of-science-crispr-cas9-and-asilomar/. Zugegriffen am 12.06.2017
  10. Gyngell C, Douglas T, Savulescu J (2015) Editing the germline – a time for reason, not emotion. http://blog.practicalethics.ox.ac.uk/2015/03/editing-the-germline-a-time-for-reason-not-emotion/. Zugegriffen am 12.06.2017
  11. Knoepfler Lab (2015a) A conversation with George Church on genomics & germline human genetic modification, 9 März 2015. https://ipscell.com/2015/03/georgechurchinterview/. Zugegriffen am 12.06.2017
  12. Knoepfler Lab (2015b) Scientists in China create genetically modified human embryos: „a cautionary tale“, 22 April 2015. https://ipscell.com/2015/04/gmhumanembryos/. Zugegriffen am 12.06.2017
  13. Knoepfler Lab (2015c) Practical plan for managing human germline genetic modification, 20 März 2015. https://ipscell.com/2015/03/abcd-plan/. Zugegriffen am 12.06.2017
  14. Knoepfler Lab (2015d) ISSCR calls for moratorium on clinical application of human germline nuclear genome editing, 19 März 2015. https://ipscell.com/2015/03/isscrgermediting/. Zugegriffen am 12.06.2017
  15. Knoepfler Lab (2015e) Report from Stanford event: human germline modification: medicine, science, ethics, & law, 18 Mai 2015. https://ipscell.com/2015/05/stanfordhumangm/. Zugegriffen am 29.08.2017
  16. Knoepfler Lab (2015f) Steven Pinker interview: case against bioethocrats & CRISPR germline ban, 10 August 2015. https://ipscell.com/2015/08/stevenpinker/. Zugegriffen am 12.06.2017
  17. Lanphier E, Urnov F, Haecker SE, Werner M, Smolenski J (2015) Don’t edit the human germ line. Nature 519(7544):410–411CrossRefGoogle Scholar
  18. Liang P, Xu Y, Zhang X, Ding C, Huang R, Zhang Z, Lv J, Xie X, Chen Y, Li Y, Sun Y, Bai Y, Songyang Z, Ma W, Zhou C, Huang J (2015) CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes. Protein Cell 6(5):363–372CrossRefGoogle Scholar
  19. McGee G (1997) The perfect baby: a pragmatic approach to genetics. Rowman und Littlefield, LanhamGoogle Scholar
  20. PBS (o. J.) Interview: Lee Silver. http://www.pbs.org/wgbh/pages/frontline/shows/fertility/interviews/silver.html. Zugegriffen am 12.06.2017
  21. Reardon S (2015) US science academies take on human-genome editing. Nature news, 18 Mai 2015. http://www.nature.com/news/us-science-academies-take-on-human-genome-editing-1.17581. Zugegriffen am 12.06.2017
  22. Regalado A (2015) Engineering the perfect baby. https://www.technologyreview.com/s/535661/engineering-the-perfect-baby/. Zugegriffen am 06.06.2017
  23. Stanfordlawschool (2015) Discussion | Human germline modification: medicine, science, ethics, and law. YouTube-Video. https://www.youtube.com/watch?v=Im58UUFzPuA. Zugegriffen am 12.06.2017
  24. Suzuki T, Asami M, Perry ACF (2014) Asymmetric parental genome engineering by Cas9 during mouse meiotic exit. Sci Rep 4(7621)Google Scholar
  25. Tatlow DK (2015) A scientific ethical divide between China and West. The New York Times, 29 Juni 2015. https://www.nytimes.com/2015/06/30/science/a-scientific-ethical-divide-between-china-and-west.html?_r=2. Zugegriffen am 12.06.2017
  26. Vogel G (2015) Bioethics. Embryo engineering alarm. Science 347(6228):1301CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Deutschland 2018

Authors and Affiliations

  • Paul Knoepfler
    • 1
  1. 1.School of MedicineUC Davis Health SystemDavisVereinigte Staaten von Amerika

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