Protonation Equilibria

  • Philipp O. J. SchererEmail author
  • Sighart F. Fischer
Part of the Biological and Medical Physics, Biomedical Engineering book series (BIOMEDICAL)


Some of the amino acid residues building a protein can be in different protonation states and therefore differently charged states. In this chapter, we discuss the dependence of the free energy of a protein on the electrostatic interactions of its charged residues. We investigate the chemical equilibrium between a large number of different protein conformations and the dependence on the pH value. The partition function is evaluated and the results are applied to explain abnormal titration curves of coupled residues.

Supplementary material

Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  1. 1.Physikdepartment T38Technische Universität MünchenGarchingGermany

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