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Immunologie der fetomaternalen Grenze

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Die Plazenta

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Zusammenfassung

Die Schwangerschaft stellt die einzigartige Situation dar, in der zwei allogene Organismen, Mutter und Fetus, ohne Abstoßungsreaktionen in Symbiose zusammenleben. Die Plazenta bildet dabei den größten Teil der Grenzfläche und ist somit von besonderer immunologischer Bedeutung. Verschiedenste plazentare Faktoren, großenteils von Trophoblastzellen produziert und sezerniert, induzieren eine weitgehend spezifische Toleranz gegenüber dem Embryo oder Fetus, ohne dabei die eigentlichen Funktionen des Immunsystems grundlegend zu verändern. Störungen dieser Toleranz können zu allen Zeitpunkten den Schwangerschaftsverlauf beeinträchtigen oder eine Schwangerschaft gar nicht erst zustande kommen lassen. Immunologische Parameter haben daher das Potenzial, als diagnostische Marker und für neue Behandlungsstrategien genutzt zu werden. Das vorliegende Kapitel soll einen groben Eindruck in die komplexe Thematik vermitteln.

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Authors and Affiliations

  1. Forschungszentrum Lobeda, Haus 2, Placenta Labor, Universitätsklinikum Jena, Forschungszentrum Lobeda, Haus 2, Jena, Deutschland

    Udo R. Markert

  2. Abteilung für Geburtsmedizin, Placenta Labor, Universitätsklinikum Jena, Jena, Deutschland

    Johanna Seitz & Theresa Hofmann

  3. Klinik für Anästhesie und Intensivmedizin, Jena, Deutschland

    Juliane Götze

  4. Klinik für Anästhesie und Intensivmedizin, Universitätsklinikum Jena, Mainz, Deutschland

    Sebastian Schamberger

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  1. Udo R. Markert
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  2. Johanna Seitz
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  3. Theresa Hofmann
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  4. Juliane Götze
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  5. Sebastian Schamberger
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Correspondence to Udo R. Markert .

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Editors and Affiliations

  1. Ordinarius, Lehrstuhl für Zellbiologie Histologie und Embryologie, Gottfried Schatz Forschungszentrum, Medizinische Universität Graz, Graz, Austria

    Berthold Huppertz

  2. Klinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Jena, Jena, Germany

    Ekkehard Schleußner

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Markert, U., Seitz, J., Hofmann, T., Götze, J., Schamberger, S. (2018). Immunologie der fetomaternalen Grenze. In: Huppertz, B., Schleußner, E. (eds) Die Plazenta. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-55622-1_2

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  • DOI: https://doi.org/10.1007/978-3-662-55622-1_2

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