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Kraniopharyngeome

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Zusammenfassung

Kraniopharyngeome sind relativ seltene, langsam wachsende, extraaxiale, benigne, teils zystische epitheliale Tumoren der Sellaregion. Symptome entwickeln sich häufig schleichend und werden durch Kompression der Hypophyse, des Thalamus, des dritten Ventrikels und des optischen Systems verursacht. Die radikale chirurgische Resektion ist eine große Herausforderung und kann schwere Komplikationen verursachen. Die Behandlung wird teils kontrovers diskutiert, die beiden hauptsächlich durchgeführten Optionen sind entweder eine makroskopisch vollständige Resektion oder eine geplante Teilresektion mit anschließender Radiatio. Es gibt eine Fülle chirurgischer Zugänge, von denen keiner grundsätzlich überlegen ist, jedoch sind sie in ihrer Gesamtheit nützlich, um einen fallspezifischen Zugang auszuwählen.

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Literatur

  • Abrams LS, Repka MX (1997) Visual outcome of craniopharyngioma in children. J Pediatr Ophthalmol Strabismus 34: 223–228

    Google Scholar 

  • Adler JR, Gibbs IC, Puataweepong P, Chang SD (2006) Visual field preservation after multisession cyberknife radiosurgery for perioptic lesions. Neurosurgery 59: 244–254

    Google Scholar 

  • Ansari SF, Moore RJ, Boaz JC, Fulkerson DH (2015) Efficacy of phosphorus-32 brachytherapy without external-beam radiation for long-term tumor control in patients with craniopharyngioma. J Neurosurg Pediatr 1–7

    Google Scholar 

  • Barlas O, Bayindir C, Can M (2000) Interstitial irradiation for craniopharyngioma. Acta Neurochir (Wien) 142: 389–395

    Google Scholar 

  • Bunin GR, Surawicz TS, Witman PA, Preston-Martin S, Davis F, Bruner JM (1998) The descriptive epidemiology of craniopharyngioma. J Neurosurg 89: 547–551

    Google Scholar 

  • Cavalheiro S, Sparapani FV, Franco JO, da Silva MC, Braga FM (1996) Use of bleomycin in intratumoral chemotherapy for cystic craniopharyngioma. Case report. J Neurosurg 84: 124–126

    Google Scholar 

  • Cavalheiro S, Di Rocco C, Valenzuela S, Dastoli PA, Tamburrini G, Massimi L, Nicacio JM, Faquini IV, Ierardi DF, Silva NS, Pettorini BL, Toledo SR (2010) Craniopharyngiomas: Intratumoral chemotherapy with interferon-alpha: A multicenter preliminary study with 60 cases. Neurosurg Focus 28: E12

    Google Scholar 

  • Cavallo LM, Frank G, Cappabianca P, Solari D, Mazzatenta D, Villa A, Zoli M, D’Enza AI, Esposito F, Pasquini E (2014) The endoscopic endonasal approach for the management of craniopharyngiomas: A series of 103 patients. J Neurosurg 121: 100–113

    Google Scholar 

  • Clark AJ, Cage TA, Aranda D, Parsa AT, Auguste KI, Gupta N (2012) Treatment-related morbidity and the management of pediatric craniopharyngioma: A systematic review. J Neurosurg Pediatr 10: 293–301

    Google Scholar 

  • Clark AJ, Cage TA, Aranda D, Parsa AT, Sun PP, Auguste KI, Gupta N (2013) A systematic review of the results of surgery and radiotherapy on tumor control for pediatric craniopharyngioma. Childs Nerv Syst 29: 231–238

    Google Scholar 

  • Conroy R, Gomes L, Owen C, Buchsbaum J, Ahern V (2015) Clinical equipoise: Protons and the child with craniopharyngioma. J Med Imaging Radiat Oncol 59: 379–385

    Google Scholar 

  • Dastoli PA, Nicacio JM, Silva NS, Capellano AM, Toledo SR, Ierardi D, Cavalheiro S (2011) Cystic craniopharyngioma: Intratumoral chemotherapy with alpha interferon. Arq Neuropsiquiatr 69: 50–55

    Google Scholar 

  • Eldevik OP, Blaivas M, Gabrielsen TO, Hald JK, Chandler WF (1996) Craniopharyngioma: Radiologic and histologic findings and recurrence. AJNR Am J Neuroradiol 17: 1427–1439

    Google Scholar 

  • Fernandez-Miranda JC, Gardner PA, Snyderman CH, Devaney KO, Strojan P, Suarez C, Genden EM, Rinaldo A, Ferlito A (2012) Craniopharyngioma: A pathologic, clinical, and surgical review. Head Neck 34: 1036–1044

    Google Scholar 

  • Gutin PH, Klemme WM, Lagger RL, MacKay AR, Pitts LH, Hosobuchi Y (1980) Management of the unresecTable cystic craniopharyngioma by aspiration through an ommaya reservoir drainage system. J Neurosurg 52: 36–40

    Google Scholar 

  • Ha EJ, Gwak HS, Rhee CH, Youn SM, Choi CW, Cheon GJ (2013) Intracavitary radiation therapy for recurrent cystic brain tumors with holmium-166-chico : A pilot study. J Korean Neurosurg Soc 54: 175–182

    Google Scholar 

  • Hargrave DR (2006) Does chemotherapy have a role in the management of craniopharyngioma? J Pediatr Endocrinol Metab 19 (Suppl 1): 407–412

    Google Scholar 

  • Hasegawa T, Kondziolka D, Hadjipanayis CG, Lunsford LD (2004) Management of cystic craniopharyngiomas with phosphorus-32 intracavitary irradiation. Neurosurgery 54: 813–820; discussion 820–812

    Google Scholar 

  • Hasegawa T, Kobayashi T, Kida Y (2010) Tolerance of the optic apparatus in single-fraction irradiation using stereotactic radiosurgery: Evaluation in 100 patients with craniopharyngioma. Neurosurgery 66: 688–694; discussion 694–685

    Google Scholar 

  • Hashizume C, Mori Y, Kobayashi T, Shibamoto Y, Nagai A, Hayashi N (2010) Stereotactic radiotherapy using novalis for craniopharyngioma adjacent to optic pathways. J Neurooncol 98: 239–247

    Google Scholar 

  • Hoffman HJ (1994) Surgical management of craniopharyngioma. Pediatr Neurosurg 21 (Suppl 1): 44–49

    Google Scholar 

  • Hoffmann A, Warmth-Metz M, Gebhardt U, Pietsch T, Pohl F, Kortmann RD, Calaminus G, Muller HL (2014) Childhood craniopharyngioma - changes of treatment strategies in the trials kraniopharyngeom 2000/2007. Klin Padiatr 226: 161–168

    Google Scholar 

  • Hoffmann A, Boekhoff S, Gebhardt U, Sterkenburg AS, Daubenbuchel AM, Eveslage M, Muller HL (2015a) History before diagnosis in childhood craniopharyngioma: Associations with initial presentation and long-term prognosis. Eur J Endocrinol 173: 853–862

    Google Scholar 

  • Hoffmann A, Postma FP, Sterkenburg AS, Gebhardt U, Muller HL (2015b) Eating behavior, weight problems and eating disorders in 101 long-term survivors of childhood-onset craniopharyngioma. J Pediatr Endocrinol Metab 28: 35–43

    Google Scholar 

  • Honegger J, Barocka A, Sadri B, Fahlbusch R (1998) Neuropsychological results of craniopharyngioma surgery in adults: A prospective study. Surg Neurol 50: 19–28; discussion 28–19

    Google Scholar 

  • Jeswani S, Nuno M, Wu A, Bonert V, Carmichael JD, Black KL, Chu R, King W, Mamelak AN (2016) Comparative analysis of outcomes following craniotomy and expanded endoscopic endonasal transsphenoidal resection of craniopharyngioma and related tumors: A single-institution study. J Neurosurg 124: 627–638

    Google Scholar 

  • Karavitaki N, Brufani C, Warner JT, Adams CB, Richards P, Ansorge O, Shine B, Turner HE, Wass JA (2005) Craniopharyngiomas in children and adults: Systematic analysis of 121 cases with long-term follow-up. Clin Endocrinol (Oxf) 62: 397–409

    Google Scholar 

  • Kickingereder P, Maarouf M, El Majdoub F, Fuetsch M, Lehrke R, Wirths J, Luyken K, Schomaecker K, Treuer H, Voges J, Sturm V (2012) Intracavitary brachytherapy using stereotactically applied phosphorus-32 colloid for treatment of cystic craniopharyngiomas in 53 patients. J Neurooncol 109: 365–374

    Google Scholar 

  • Kim SD, Park JY, Park J, Lee JB, Kim SH, Lim DJ (2007) Radiological findings following postsurgical intratumoral bleomycin injection for cystic craniopharyngioma. Clin Neurol Neurosurg 109: 236–241

    Google Scholar 

  • Kobayashi T (2009) Long-term results of gamma knife radiosurgery for 100 consecutive cases of craniopharyngioma and a treatment strategy. Prog Neurol Surg 22: 63–76

    Google Scholar 

  • Koutourousiou M, Gardner PA, Fernandez-Miranda JC, Tyler-Kabara EC, Wang EW, Snyderman CH (2013) Endoscopic endonasal surgery for craniopharyngiomas: Surgical outcome in 64 patients. J Neurosurg 119: 1194–1207

    Google Scholar 

  • Laprie A, Hu Y, Alapetite C, Carrie C, Habrand JL, Bolle S, Bondiau PY, Ducassou A, Huchet A, Bertozzi AI, Perel Y, Moyal E, Balosso J, radiotherapy committee of S, France H (2015) Paediatric brain tumours: A review of radiotherapy, state of the art and challenges for the future regarding protontherapy and carbontherapy. Cancer Radiother 19: 775–789

    Google Scholar 

  • Lovstad M, Funderud I, Endestad T, Due-Tonnessen P, Meling TR, Lindgren M, Knight RT, Solbakk AK (2012) Executive functions after orbital or lateral prefrontal lesions: Neuropsychological profiles and self-reported executive functions in everyday living. Brain Inj 26: 1586–1598

    Google Scholar 

  • Luo S, Pan J, Qi ST, Fang LX, Fan J, Liu BG (2009) [analysis of the factors contributing to diabetes insipidus after surgeries for craniopharyngiomas]. Nan Fang Yi Ke Da Xue Xue Bao 29: 544–547

    Google Scholar 

  • Merchant TE, Kiehna EN, Kun LE, Mulhern RK, Li C, Xiong X, Boop FA, Sanford RA (2006) Phase ii trial of conformal radiation therapy for pediatric patients with craniopharyngioma and correlation of surgical factors and radiation dosimetry with change in cognitive function. J Neurosurg 104: 94–102

    Google Scholar 

  • Mortini P, Losa M, Pozzobon G, Barzaghi R, Riva M, Acerno S, Angius D, Weber G, Chiumello G, Giovanelli M (2011) Neurosurgical treatment of craniopharyngioma in adults and children: Early and long-term results in a large case series. J Neurosurg 114: 1350–1359

    Google Scholar 

  • Mortini P, Gagliardi F, Bailo M, Spina A, Parlangeli A, Falini A, Losa M (2016) Magnetic resonance imaging as predictor of functional outcome in craniopharyngiomas. Endocrine 51: 148–162

    Google Scholar 

  • Mottolese C, Szathmari A, Berlier P, Hermier M (2005) Craniopharyngiomas: Our experience in lyon. Childs Nerv Syst 21: 790–798

    Google Scholar 

  • Muller HL, Gebhardt U, Etavard-Gorris N, Korenke E, Warmuth-Metz M, Kolb R, Sorensen N, Calaminus G (2004) Prognosis and sequela in patients with childhood craniopharyngioma – results of hit-endo and update on kraniopharyngeom 2000. Klin Padiatr 216: 343–348

    Google Scholar 

  • Olsson DS, Andersson E, Bryngelsson IL, Nilsson AG, Johannsson G (2015) Excess mortality and morbidity in patients with craniopharyngioma, especially in patients with childhood onset: A population-based study in sweden. J Clin Endocrinol Metab 100: 467–474

    Google Scholar 

  • Ozyurt J, Muller HL, Thiel CM (2015) A systematic review of cognitive performance in patients with childhood craniopharyngioma. J Neurooncol 125: 9–21

    Google Scholar 

  • Pascual JM, Prieto R, Castro-Dufourny I, Carrasco R, Strauss S, Barrios L (2014) Development of intracranial approaches for craniopharyngiomas: An analysis of the first 160 historical procedures. Neurosurg Focus 36: E13

    Google Scholar 

  • Prieto R, Pascual JM, Barrios L (2015) Optic chiasm distortions caused by craniopharyngiomas: Clinical and magnetic resonance imaging correlation and influence on visual outcome. World Neurosurg 83: 500–529

    Google Scholar 

  • Pulsifer MB, Sethi RV, Kuhlthau KA, MacDonald SM, Tarbell NJ, Yock TI (2015) Early cognitive outcomes following proton radiation in pediatric patients with brain and central nervous system tumors. Int J Radiat Oncol Biol Phys 93: 400–407

    Google Scholar 

  • Rahmathulla G, Barnett GH (2013) Minimally invasive management of adult craniopharyngiomas: An analysis of our series and review of literature. Surg Neurol Int 4: S411–S421

    Google Scholar 

  • Rushing EJ, Giangaspero F, Paulus W, Burger PC (2007) Craniopharyngioma. In DN Louis, H Ohgaki, OD Wiestler & WK Canevee (Eds.), Who classification of tumours of the central nervous system, 4th ed. International Agency for Research on Cancer, Lyon, pp 238–240

    Google Scholar 

  • Sanford RA (1994) Craniopharyngioma: Results of survey of the american society of pediatric neurosurgery. Pediatr Neurosurg 21 (Suppl 1): 39–43

    Google Scholar 

  • Shi XE, Wu B, Fan T, Zhou ZQ, Zhang YL (2008) Craniopharyngioma: Surgical experience of 309 cases in china. Clin Neurol Neurosurg 110: 151–159

    Google Scholar 

  • Sklar CA (1994) Craniopharyngioma: Endocrine abnormalities at presentation. Pediatr Neurosurg 21 (Suppl 1): 18–20

    Google Scholar 

  • Steno J, Bizik I, Steno A, Matejcik V (2011) Craniopharyngiomas in children: How radical should the surgeon be? Childs Nerv Syst 27: 41–54

    Google Scholar 

  • Sughrue ME, Yang I, Kane AJ, Fang S, Clark AJ, Aranda D, Barani IJ, Parsa AT (2011) Endocrinologic, neurologic, and visual morbidity after treatment for craniopharyngioma. J Neurooncol 101: 463–476

    Google Scholar 

  • Voges J, Sturm V, Lehrke R, Treuer H, Gauss C, Berthold F (1997) Cystic craniopharyngioma: Long-term results after intracavitary irradiation with stereotactically applied colloidal beta-emitting radioactive sources. Neurosurgery 40: 263–269; discussion 269–270

    Google Scholar 

  • Wang KC, Hong SH, Kim SK, Cho BK (2005) Origin of craniopharyngiomas: Implication on the growth pattern. Childs Nerv Syst 21: 628–634

    Google Scholar 

  • Yang I, Sughrue ME, Rutkowski MJ, Kaur R, Ivan ME, Aranda D, Barani IJ, Parsa AT (2010) Craniopharyngioma: A comparison of tumor control with various treatment strategies. Neurosurg Focus 28: E5

    Google Scholar 

  • Yasargil MG, Curcic M, Kis M, Siegenthaler G, Teddy PJ, Roth P (1990) Total removal of craniopharyngiomas. Approaches and long-term results in 144 patients. J Neurosurg 73: 3–11

    Google Scholar 

  • Yeung JT, Pollack IF, Panigrahy A, Jakacki RI (2012) Pegylated interferon-alpha-2b for children with recurrent craniopharyngioma. J Neurosurg Pediatr 10: 498–503

    Google Scholar 

  • Zhang YQ, Ma ZY, Wu ZB, Luo SQ, Wang ZC (2008) Radical resection of 202 pediatric craniopharyngiomas with special reference to the surgical approaches and hypothalamic protection. Pediatr Neurosurg 44: 435–443

    Google Scholar 

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Meling, T. (2018). Kraniopharyngeome. In: König, A., Spetzger, U. (eds) Schädelbasischirurgie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-54672-7_10

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  • DOI: https://doi.org/10.1007/978-3-662-54672-7_10

  • Publisher Name: Springer, Berlin, Heidelberg

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