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Nano-Particles for Biomedical Applications

  • Paolo Decuzzi
  • Alessandro Coclite
  • Aeju Lee
  • Anna Lisa Palange
  • Daniele Di Mascolo
  • Ciro Chiappini
  • Hélder A. Santos
  • Maria Laura Coluccio
  • Gerardo Perozziello
  • Patrizio Candeloro
  • Enzo Di Fabrizio
  • Francesco Gentile
Part of the Springer Handbooks book series (SHB)

Abstract

Nanoparticles (NP s) are extremely small particulates with an average size that ranges from a micron or less to a few nanometers. The large majority of NPs necessitate nanotechnology methods for their production. The size of NPs may vary over a significant range, which underlies their scientific potential in that NPs may help cross the bridge between bulk materials and molecular structures. More importantly, NPs are (nano)tech products and thus, in contrast to natural systems, they can be designed and engineered. On directly interacting with cells, including the structures of cells, their machinery and their waste products, NPs represent an unprecedented tool for addressing specific biological problems. In this chapter, we will briefly review some recent advances in nanoparticle research for biomedical applications, ranging from mesoporous silicon particles to gold and silver nanoparticles and polymeric nanocarriers for therapeutic, diagnosis, or theranostic (therapeutics + diagnosis) applications. We will offer a description of how, at the current state of the art, similar nanomedicine platforms are realized.

Notes

Acknowledgements

Dr. Hélder A. Santos acknowledges the Academy of Finland (project numbers 252215 and 281300), the University of Helsinki and the European Research Council under the European Union's Seventh Framework Programme (FP7/2007-2013)/ERC Grant agreement number 310892 for financial support. Dr. Dongfei Liu and Dr. Bárbara Herranz Blanco (Division of Pharmaceutical Chemistry and Technology) are also acknowledged for their discussions and for providing some of the material in the microfluidics section. Professor Francesco Gentile acknowledges the Italian Minister of Health (Project number GR-2010-2320665).

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Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  • Paolo Decuzzi
    • 1
  • Alessandro Coclite
    • 1
  • Aeju Lee
    • 2
  • Anna Lisa Palange
    • 1
  • Daniele Di Mascolo
    • 1
  • Ciro Chiappini
    • 3
  • Hélder A. Santos
    • 4
  • Maria Laura Coluccio
    • 5
  • Gerardo Perozziello
    • 5
  • Patrizio Candeloro
    • 5
  • Enzo Di Fabrizio
    • 6
  • Francesco Gentile
    • 7
  1. 1.Laboratory of Nanotechnology for Precision MedicineItalian Institute of TechnologyGenovaItaly
  2. 2.International Research Organization for Advanced Science and TechnologyKumamoto UniversityKumamotoJapan
  3. 3.Craniofacial Development and Stem Cell BiologyKing‘s College LondonLondonUK
  4. 4.Division of Pharmaceutical Chemistry and TechnologyUniversity of HelsinkiHelsinkiFinland
  5. 5.Dept. of Experimental and Clinical MedicineUniversity Magna Graecia of CatanzaroCatanzaroItaly
  6. 6.Dept. of Physical Science and EngineeringKing Abdullah University of Science and TechnologyThuwalSaudi Arabia
  7. 7.Dept. of Electrical Engineering and Information TechnologyUniversity Naples Federico IINaplesItaly

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