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Use of Nutraceuticals for Tendinopathies

  • Marco Antônio Percope de AndradeEmail author
  • Guilherme Moreira de Abreu-e-Silva
  • Túlio Vinícius Oliveira de Campos
Chapter

Abstract

The importance of tendinopathies in the clinical scenario has increased recently. It may be attributed to the increase of sport activities, life expectancy, and other factors such as environment, diet, systemic diseases, and some drug therapies (e.g., fluoroquinolones). In fact, not only athletes but also the general population suffer from inflammatory or degenerative tendon conditions which may be attributed to the quality of tendon tissue and mechanical overuse (Fusini et al. 2016).

Keywords

Nitric Oxide Rotator Cuff Tendon Healing Boswellic Acid Simple Shoulder Test 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Aiyegbusi AI, Duru FI, Awelimobor D, Noronha CC, Okanlawon AO (2010) The role of aqueous extract of pineapple fruit parts on the healing of acute crush tendon injury. Nig Q J Hosp Med 20:223–227CrossRefPubMedGoogle Scholar
  2. Arbiser JL, Klauber N, Rohan R, van Leeuwen R, Huang MT, Fisher C (1998) Curcumin is an in vivo inhibitor of angiogenesis. Mol Med 4:376–383PubMedPubMedCentralGoogle Scholar
  3. Arquer A, García M, Laucirica JA (2014) Eficacia y seguridad de un tratamiento oral a base de mucopolisacáridos, colágeno tipo i y vitamina C en pacientes con tendinopatías. Apunts. Medicina de l’Esport 49:31–36CrossRefGoogle Scholar
  4. Buhrmann C, Mobasheri A, Busch F (2011) Curcumin modulates nuclear factor kappaB (NF-kappaB)-mediated inflammation in human tenocytes in vitro: role of the phosphatidylinositol 3-kinase/Akt pathway. J Biol Chem 286:28556–28566CrossRefPubMedPubMedCentralGoogle Scholar
  5. Darmani H, Crossan J, McLellan SD, Meek D, Adam C (2004) Expression of nitric oxide synthase and transforming growth factor-beta in crush-injured tendon and synovium. Mediat Inflamm 13:299–305CrossRefGoogle Scholar
  6. Fusini F et al (2016) Nutraceutical supplement in the management of tendinopathies: a systematic review. Muscles Ligaments Tendons J 6(1):48–57PubMedPubMedCentralGoogle Scholar
  7. Gumina S, Passaretti D, Gurzi MD, Candela V (2012) Arginine L-alpha-ketoglutarate, methylsulfonylmethane, hydrolyzed type I collagen and bromelain in rotator cuff tear repair: a prospective randomized study. Curr Med Res Opin 28:1767–1774CrossRefPubMedGoogle Scholar
  8. Hung LK, Fu SC, Lee YW, Mok TY, Chan KM (2013) Local vitamin-C injection reduced tendon adhesion in a chicken model of flexor digitorum profundus tendon injury. J Bone Joint Surg Am 95:e41CrossRefPubMedGoogle Scholar
  9. Jiang D, Gao P, Lin H, Geng H (2016) Curcumin improves tendon healing in rats: a histological, biochemical, and functional evaluation. Connect Tissue Res 57:20–27CrossRefPubMedGoogle Scholar
  10. Kao WW, Flaks JG, Prockop DJ (1976) Primary and secondary effects of ascorbate on procollagen synthesis and protein synthesis by primary cultures of tendon fibroblasts. Arch Biochem Biophys 173:638–648CrossRefPubMedGoogle Scholar
  11. Lippiello L (2006) Collagen synthesis in tenocytes, ligament cells and chondrocytes exposed to a combination of glucosamine HCl and chondroitin sulfate. Evid Based Complement Alternat Med 4(2):219–224CrossRefPubMedPubMedCentralGoogle Scholar
  12. Magnuson BA, Appleton J, Ames GB (2007) Pharmacokinetics and distribution of [35S]methylsulfonylmethane following oral administration to rats. J Agric Food Chem 55:1033–1038CrossRefPubMedGoogle Scholar
  13. Merolla G, Dellabiancia F, Ingardia A, Paladini P, Porcellini G (2015) Co-analgesic therapy for arthroscopic supraspinatus tendon repair pain using a dietary supplement containing Boswellia serrata and Curcuma longa: a prospective randomized placebo-controlled study. Musculoskelet Surg 99:43–52CrossRefGoogle Scholar
  14. Minaguchi J, Koyama Y, Meguri N et al (2005) Effects of ingestion of collagen peptide on collagen fibrils and glycosaminoglycans in Achilles tendon. J Nutr Sci Vitaminol 51:169–174CrossRefPubMedGoogle Scholar
  15. Moraes JR, Facco GG, Moraes FR, Filho JRE, Miyazato LG, Beretta DC (2009) Effects of glycosaminoglycan polysulphate on the organisation of collagen fibres in experimentally induced tendonitis in horses. Vet Rec 165:203–205CrossRefPubMedGoogle Scholar
  16. Murrell GA (2007a) Using nitric oxide to treat tendinopathy. Br J Sports Med 41:227–231CrossRefPubMedPubMedCentralGoogle Scholar
  17. Murrell GA (2007b) Oxygen free radicals and tendon healing. J Shoulder Elbow Surg 16:208–214CrossRefGoogle Scholar
  18. Murrell GA, Szabo C, Hannafin JA (1997) Modulation of tendon healing by nitric oxide. Inflamm Res 46:19–27CrossRefPubMedGoogle Scholar
  19. Notarnicola A, Pesce V, Vicenti G, Tafuri S, Forcignano M, Moretti B (2012) SWAAT study: extracorporeal shock wave therapy and arginine supplementation and other nutraceuticals for insertional Achilles tendinopathy. Adv Ther 29:799–814CrossRefPubMedGoogle Scholar
  20. Omeroglu S, Peker T, Turkozkan N, Omeroglu H (2009) High-dose vitamin C supplementation accelerates the Achilles tendon healing in healthy rats. Arch Orthop Trauma Surg 129:281–286CrossRefPubMedGoogle Scholar
  21. Oryan A, Goodship AE, Silver IA (2008) Response of a collagenase-induced tendon injury to treatment with a polysulphated glycosaminoglycan (Adequan). Connect Tissue Res 49:351–360CrossRefPubMedGoogle Scholar
  22. Ozer H, Taskesen A, Kul O, Selek HY, Turanli S, Kose K (2011) Effect of glucosamine chondroitin sulphate on repaired tenotomized rat Achilles tendons. Jt Dis Relat Surg 22:100–106Google Scholar
  23. Pari L, Murugan P (2007) Influence of tetrahydrocurcumin on tail tendon collagen contents and its properties in rats with streptozotocin-nicotinamide-induced type 2 diabetes. Fundam Clin Pharmacol 21:665–671CrossRefPubMedGoogle Scholar
  24. Percope de Andrade MA, Campos TV, Abreu-E-Silva GM (2015) Supplementary methods in the nonsurgical treatment of osteoarthritis. Arthroscopy 31(4):785–792CrossRefPubMedGoogle Scholar
  25. Sajithlal GB, Chithra P, Chandrakasan G (1998) Effect of curcumin on the advanced glycation and cross-linking of collagen in diabetic rats. Biochem Pharmacol 56:1607–1614CrossRefPubMedGoogle Scholar
  26. Schwarz RI, Mandell RB, Bissell MJ (1981) Ascorbate induction of collagen synthesis as a means for elucidating a mechanism of quantitative control of tissue-specific function. Mol Cell Biol 1:843–853CrossRefPubMedPubMedCentralGoogle Scholar
  27. Shakibaei M, Buhrmann C, Mobasheri A (2011) Anti-inflammatory and anti-catabolic effects of TENDOACTIVE® on human tenocytes in vitro. Histol Histopathol 26:1173–1185PubMedGoogle Scholar
  28. Sundqvist H, Forsskahl B, Kvist M (1987) A promising novel therapy for Achilles peritendinitis: double-blind comparison of glycosaminoglycan polysulfate and high-dose indomethacin. Int J Sports Med 8:298–303CrossRefPubMedGoogle Scholar

Copyright information

© ISAKOS 2017

Authors and Affiliations

  • Marco Antônio Percope de Andrade
    • 1
    • 2
    Email author
  • Guilherme Moreira de Abreu-e-Silva
    • 1
  • Túlio Vinícius Oliveira de Campos
    • 1
  1. 1.Orthopaedic DepartmentUniversidade Federal de Minas GeraisBelo HorizonteBrazil
  2. 2.Departamento de Aparelho LocomotorUniversidade Federal de Minas GeraisBelo HorizonteBrazil

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