Abstract
Pancreatic neuroendocrine tumors (PNETs) comprise a spectrum of slower-growing neoplasms (in comparison with adenocarcinoma of the pancreas) that arise from the pancreatic islets. Because patients with PNETs have a different natural history than those with adenocarcinoma, they present a different spectrum of management challenges. For example, unlike patients with pancreatic adenocarcinoma, patients with PNETs:
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May have survival durations measured in years, even with metastatic disease
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Often require complex management of the pancreatic tumor (local disease) because of their favorable survival outlook—especially in the setting of a large primary tumor, biliary obstruction, intravascular extension of tumor, or adjacent organ involvement
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May benefit from concomitant resection of both the primary tumor and metastases, which are most often in the liver
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May demonstrate dramatic responses to systemic therapy, with significant change in the size of the primary tumor or associated metastases.
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Amini, A., Evans, D.B., Christians, K.K. (2017). Pancreaticoduodenectomy for Neuroendocrine Tumors. In: Howe, J. (eds) Endocrine and Neuroendocrine Surgery. Springer Surgery Atlas Series. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-54067-1_15
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DOI: https://doi.org/10.1007/978-3-662-54067-1_15
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