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Biomaterials for Implants and Scaffolds pp 319–347Cite as

Characterisation of Hydrogel Scaffolds Under Compression

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Part of the book series: Springer Series in Biomaterials Science and Engineering ((SSBSE,volume 8))

Abstract

Although a variety of scaffolds have been developed in recent years for a range of applications, the repair of load-bearing tissues, such as articular cartilage in the knee, is still in its infancy due to the exceptional demands on mechanical strength and stiffness. Unfortunately, rigorous in vitro mechanical characterisation has often been superseded by in vivo testing in animals, where the loading scenarios often bear little resemblance to those in human, which has significantly restricted the potential range of clinical applications. A comprehensive mechanical characterisation is essential if scaffolds are to be used for load-bearing applications. In this chapter, we report the characterisation of viscoelastic behaviour of hydrogel scaffolds. The key factors, including the effects of constraint, strain rate and sample microstructure, on the mechanical properties of a hydrogel scaffold will be investigated. Some of the latest techniques such as micro-CT imaging, in situ image-guided failure assessment and digital volume correlation (DVC) will be explored in the characterisation of the hydrogel scaffold under uniaxial compression.

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Acknowledgements

The authors would like to acknowledge Smith & Nephew for providing the samples and the University of Portsmouth for financial support.

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Authors and Affiliations

  1. School of Engineering, University of Portsmouth, Anglesea Building, Anglesea Road, Portsmouth, PO1 3DJ, UK

    J. Tong, Y.-H. Hsu & K. Madi

  2. Spire Portsmouth Hospital, Portsmouth, PO9 5NP, UK

    A. Cossey

  3. Smith & Nephew, 150 Minuteman Rd, Andover, MA, 01810, USA

    A. Au

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  1. J. Tong
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  2. Y.-H. Hsu
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  3. K. Madi
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  4. A. Cossey
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  5. A. Au
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Corresponding author

Correspondence to J. Tong .

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Editors and Affiliations

  1. School of Aerospace, Mechanical & Mechatronic Engineering, The University of Sydney, Sydney, New South Wales, Australia

    Qing Li

  2. School of Aerospace, Mechanical & Mechatronic Engineering, The University of Sydney, Sydney, New South Wales, Australia

    Yiu-Wing Mai

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Tong, J., Hsu, YH., Madi, K., Cossey, A., Au, A. (2017). Characterisation of Hydrogel Scaffolds Under Compression. In: Li, Q., Mai, YW. (eds) Biomaterials for Implants and Scaffolds. Springer Series in Biomaterials Science and Engineering, vol 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-53574-5_11

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