Skip to main content
SpringerLink
Log in

Perspectives on Dermal Delivery of Macromolecular Drugs

  • Chapter
  • First Online:
Percutaneous Penetration Enhancers Drug Penetration Into/Through the Skin

  • 1288 Accesses

Abstract

Topical delivery of macromolecules is a significant challenge. However, the increasing need in dermatology for the topical application of biodrugs, including proteins, peptides and nucleic acids calls for the development of novel approaches. In this perspective chapter we highlight several examples of advancement using physical and chemical methods.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Baca-Estrada ME, Foldvari M, Babiuk SL, Babiuk LA (2000a) Vaccine delivery: lipid-based delivery systems. J Biotechnol 83:91–104

    Article  CAS  PubMed  Google Scholar 

  • Baca-Estrada ME, Foldvari M, Ewen C, Badea I, Babiuk LA (2000b) Effects of IL-12 on immune responses induced by transcutaneous immunization with antigens formulated in a novel lipid-based biphasic delivery system. Vaccine 18:1847–1854

    Article  CAS  PubMed  Google Scholar 

  • Barry BW (2001) Novel mechanisms and devices to enable successful transdermal drug delivery. Eur J Pharm Sci 14:101–114

    Article  CAS  PubMed  Google Scholar 

  • Benson HA (2006) Transfersomes for transdermal drug delivery. Expert Opin Drug Deliv 3:727–737

    Article  CAS  PubMed  Google Scholar 

  • Birchall JC, Marichal C, Campbell L, Alwan A, Hadgraft J, Gumbleton M (2000) Gene expression in an intact ex-vivo skin tissue model following percutaneous delivery of cationic liposome-plasmid DNA complexes. Int J Pharm 197:233–238

    Article  CAS  PubMed  Google Scholar 

  • Bos JD, Meinardi MM (2000) The 500 Dalton rule for the skin penetration of chemical compounds and drugs. Exp Dermatol 9:165–169

    Article  CAS  PubMed  Google Scholar 

  • Cevc G, Gebauer D, Stieber J, Schatzlein A, Blume G (1998) Ultraflexible vesicles, Transfersomes, have an extremely low pore penetration resistance and transport therapeutic amounts of insulin across the intact mammalian skin. Biochim Biophys Acta 1368:201–215

    Article  CAS  PubMed  Google Scholar 

  • Charoo NA, Rahman Z, Repka MA, Murthy SN (2010) Electroporation: an avenue for transdermal drug delivery. Curr Drug Deliv 7:125–136

    Article  CAS  PubMed  Google Scholar 

  • Delepine P, Guillaume C, Floch V, Loisel S, Yaouanc J, Clement J, Des Abbayes H, Ferec C (2000) Cationic phosphonolipids as nonviral vectors: in vitro and in vivo applications. J Pharm Sci 89:629–638

    Article  CAS  PubMed  Google Scholar 

  • Elsabahy M, Foldvari M (2013) Needle-free gene delivery through the skin: an overview of recent strategies. Curr Pharm Des 19(41):7301–7315

    Article  CAS  PubMed  Google Scholar 

  • Escobar-Chavez JJ, Bonilla-Martinez D, Villegas-Gonzalez MA, Molina-Trinidad E, Casas-Alancaster N, Revilla-Vazquez AL (2011) Microneedles: a valuable physical enhancer to increase transdermal drug delivery. J Clin Pharmacol 51:964–977

    Article  CAS  PubMed  Google Scholar 

  • Foldvari M (2000) Non-invasive administration of drugs through the skin: challenges in delivery system design. Pharm Sci Technol Today 3:417–425

    Article  CAS  PubMed  Google Scholar 

  • Foldvari M (2010) Biphasic vesicles: a novel topical drug delivery system. J Biomed Nanotechnol 6:543–557

    Article  CAS  PubMed  Google Scholar 

  • Foldvari M, Badea I, Wettig S, Baboolal D, Kumar P, Creagh AL, Haynes CA (2010) Topical delivery of interferon alpha by biphasic vesicles: evidence for a novel nanopathway across the stratum corneum. Mol Pharm 7:751–762

    Article  CAS  PubMed  Google Scholar 

  • Glogau R, Blitzer A, Brandt F, Kane M, Monheit GD, Waugh JM (2012) Results of a randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of a botulinum toxin type A topical gel for the treatment of moderate-to-severe lateral canthal lines. J Drugs Dermatol 11:38–45

    CAS  PubMed  Google Scholar 

  • Gratieri T, Kalaria D, Kalia YN (2011) Non-invasive iontophoretic delivery of peptides and proteins across the skin. Expert Opin Drug Deliv 8:645–663

    Article  CAS  PubMed  Google Scholar 

  • King MJ, Badea I, Solomon J, Kumar P, Gaspar KJ, Foldvari M (2002) Transdermal delivery of insulin from a novel biphasic lipid system in diabetic rats. Diabetes Technol Ther 4:479–488

    Article  PubMed  Google Scholar 

  • Lee JW, Gadiraju P, Park JH, Allen MG, Prausnitz MR (2011) Microsecond thermal ablation of skin for transdermal drug delivery. J Control Release 154(1):58–68. doi:10.1016/j.jconrel.2011.05.003

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lisziewicz J, Bakare N, Calarota SA, Banhegyi D, Szlavik J, Ujhelyi E, Toke ER, Molnar L, Lisziewicz Z, Autran B, Lori F (2012) Single DermaVir immunization: dose-dependent expansion of precursor/memory T cells against All HIV antigens in HIV-1 infected individuals. PLoS One 7, e35416

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mccrudden MT, Singh TR, Migalska K, Donnelly RF (2013) Strategies for enhanced peptide and protein delivery. Ther Deliv 4:593–614

    Article  CAS  PubMed  Google Scholar 

  • Prausnitz MR, Langer R (2008) Transdermal drug delivery. Nat Biotechnol 26:1261–1268

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Puglia C, Bonina F (2012) Lipid nanoparticles as novel delivery systems for cosmetics and dermal pharmaceuticals. Expert Opin Drug Deliv 9:429–441

    Article  CAS  PubMed  Google Scholar 

  • Schreief H, Bouwstrab J (1994) Liposomes and niosomes as topical drug carriers: dermal and transdermal drug delivery. J Control Release 30:1–15

    Article  Google Scholar 

  • Schuetz YB, Naik A, Guy RH, Kalia YN (2005) Emerging strategies for the transdermal delivery of peptide and protein drugs. Expert Opin Drug Deliv 2:533–548

    Article  CAS  PubMed  Google Scholar 

  • Shi Z, Curiel DT, Tang DC (1999) DNA-based non-invasive vaccination onto the skin. Vaccine 17:2136–2141

    Article  CAS  PubMed  Google Scholar 

  • Shilpa S, Srinivasan BP, Chauhan M (2011) Niosomes as vesicular carriers for delivery of proteins and biologicals. Int J Drug Deliv 3:14–24

    Article  CAS  Google Scholar 

  • Watabe S, Xin KQ, Ihata A, Liu LJ, Honsho A, Aoki I, Hamajima K, Wahren B, Okuda K (2001) Protection against influenza virus challenge by topical application of influenza DNA vaccine. Vaccine 19:4434–4444

    Article  CAS  PubMed  Google Scholar 

  • Xu Y, Hui SW, Frederik P, Szoka FC Jr (1999) Physicochemical characterization and purification of cationic lipoplexes. Biophys J 77:341–353

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yu WH, Kashani-Sabet M, Liggitt D, Moore D, Heath TD, Debs RJ (1999) Topical gene delivery to murine skin. J Invest Dermatol 112:370–375

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. School of Pharmacy, University of Waterloo, 200 University Avenue West, Waterloo, ON, N2L 3G1, Canada

    Marianna Foldvari

  2. Helix BioPharma Inc., #109-111 Research Drive, Saskatoon, SK, S7N 3R2, Canada

    P. Kumar

Authors
  1. Marianna Foldvari
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P. Kumar
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Marianna Foldvari .

Editor information

Editors and Affiliations

  1. Apoteka “Beograd”, Belgrade, Serbia

    Nina Dragicevic

  2. San Francisco, California, USA

    Howard I. Maibach

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Foldvari, M., Kumar, P. (2017). Perspectives on Dermal Delivery of Macromolecular Drugs. In: Dragicevic, N., I. Maibach, H. (eds) Percutaneous Penetration Enhancers Drug Penetration Into/Through the Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-53270-6_21

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-53270-6_21

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-53268-3

  • Online ISBN: 978-3-662-53270-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation