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Acquired Melanocytic Nevus

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Pathology of Pigmented Skin Lesions

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Abstract

Melanocytic nevi are defined as benign hamartomatous lesions composed of melanocytes. Melanocytes are derived from the neural crest and migrate during embryogenesis to selected ectodermal sites, primarily the skin and the central nervous system, including the eyes and the ears; however, ectopic melanocytes have been found in other organs such as multiple locations of the gastrointestinal tract. Acquired melanocytic nevi commonly form during early childhood and their onset is believed, at least in some cases, to be a response to sun exposure. However genetic factors are also involved in the development of some types of acquired nevi. Melanocytic nevi are biologically stable, benign lesions but in some occasions they can be associated with melanoma. The frequency of transformation of a melanocytic nevus into melanoma varies widely in the literature, with some data suggesting that up to 40 % of melanomas are associated with a precursor nevus.

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Authors and Affiliations

  1. Division of Dermatopathology, Miraca Life Sciences, Dallas, TX, USA

    Jose A. Plaza

  2. MD Anderson Cancer Center, University of Texas, Houston, TX, USA

    Victor G. Prieto

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  1. Jose A. Plaza
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Plaza, J.A., Prieto, V.G. (2017). Acquired Melanocytic Nevus. In: Pathology of Pigmented Skin Lesions. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-52721-4_3

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