Skip to main content

Gerinnungsphysiologie bei Totgeburten

  • Chapter
  • First Online:
Fehlgeburten Totgeburten Frühgeburten
  • 4366 Accesses

Zusammenfassung

Der intrauterine Fruchttod kann verschiedene Ursachen haben. Es werden Ergebnisse aus Studien zum Zusammenhang zwischen dem intrauterinen Fruchttod und hereditären sowie erworbenen Thrombophilien dargestellt. Darüber hinaus werden prophylaktische Optionen diskutiert.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 64.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 84.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Notes

  1. 1.

    Auf die Bedeutung, Häufigkeit, Komplikationen und mögliche Therapieoptionen bei Vorliegen einer maternalen Thrombophilie wurde bereits in Kap. 17 in Hinblick auf das Auftreten habitueller Frühaborte eingegangen.

Literatur

  • Alfirevic Z, Roberts D, Martlew V (2002) How strong is the association between maternal thrombophilia and adverse pregnancy outcome? A systematic review Eur J Obstet Gynecol Reprod Biol 101: 6–14

    Article  PubMed  Google Scholar 

  • Aracic N, Roje D, Drmic Hofman I, Capkun V, Stefanovic V (2015) Low molecular weight heparin treatment and impact of inherited thrombophilia type in pregnancies with previous adverse outcome. J Matern Fetal Neonatal Med 28: 306–310

    Article  CAS  PubMed  Google Scholar 

  • Beeksma FA, Erwich JJ, Khong TY (2012) Placental fetal vascular thrombosis lesions and maternal thrombophilia. Pathology 44: 24–28

    Article  CAS  PubMed  Google Scholar 

  • Bertolaccini ML, Mepani K, Sanna G, Hughes GR, Khamashta MA (2007) Factor XII autoantibodies as a novel marker for thrombosis and adverse obstetric history in patients with systemic lupus erythematosus. Ann Rheum Dis 66: 533–536

    Article  CAS  PubMed  Google Scholar 

  • Bretelle F, Arnoux D, Shojai R, D'Ercole C, Sampol J, Dignat F, Camoin-Jau L (2005) Protein Z in patients with pregnancy complications. Am J Obstet Gynecol 193: 1698–1702

    Article  CAS  PubMed  Google Scholar 

  • Frias AE Jr, Luikenaar RA, Sullivan AE, Lee RM, Porter TF, Branch DW, Silver RM (2004) Poor obstetric outcome in subsequent pregnancies in women with prior fetal death. Obstet Gynecol 104: 521–526

    Article  PubMed  Google Scholar 

  • Ghidini A (2014) Overview of low molecular weight heparin for preventative treatment of adverse obstetric outcomes related to abnormal placentation. Prenat Diagn 34: 649–654

    PubMed  Google Scholar 

  • Hansen AT, Schmidt M, Horváth-Puhó E, Pedersen L, Rothman KJ, Hvas AM, Sørensen HT (2015) Preconception venous thromboembolism and placenta-mediated pregnancy complications. J Thromb Haemost 13: 1635–1641

    Article  CAS  PubMed  Google Scholar 

  • Hvas AM, Ingerslev J, Salvig JD (2009) Thrombophilia risk factors are associated with intrauterine foetal death and pregnancy-related venous thromboembolism. Scand J Clin Lab Invest 69: 288–294

    Article  PubMed  Google Scholar 

  • James AH, Jamison MG (2007) Bleeding events and other complications during pregnancy and childbirth in women with von Willebrand disease. J Thromb Haemost 5: 1165–1169

    Article  CAS  PubMed  Google Scholar 

  • de Jong PG, Goddijn M, Middeldorp S (2013) Antithrombotic therapy for pregnancy loss. Hum Reprod Update 19: 656–673

    Article  PubMed  Google Scholar 

  • Kumar M, Mehta P (1994) Congenital coagulopathies and pregnancy: report of four pregnancies in a factor X-deficient woman. Am J Hematol 46: 241–244

    Article  CAS  PubMed  Google Scholar 

  • Kupferminc MJ, Rimon E, Many A, Sharon M, Lessing JB, Gamzu R (2011) Low molecular weight heparin treatment during subsequent pregnancies of women with inherited thrombophilia and previous severe pregnancy complications. J Matern Fetal Neonatal Med 24: 1042–1045

    Article  CAS  PubMed  Google Scholar 

  • Martinelli I, Ruggenenti P, Cetin I, Pardi G, Perna A, Vergani P, Acaia B, Facchinetti F, La Sala GB, Bozzo M, Rampello S, Marozio L, Diadei O, Gherardi G, Carminati S, Remuzzi G, Mannucci PM (2012) Heparin in pregnant women with previous placenta-mediated pregnancy complications: a prospective, randomized, multicenter, controlled clinical trial. Blood 119: 3269–3275

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mitic G, Kovac M, Povazan L, Magic Z, Djordjevic V, Salatic I, Mitic I, Novakov-Mikic A (2010) Inherited thrombophilia is associated with pregnancy losses that occur after 12th gestational week in Serbian population. Clin Appl Thromb Hemost 16: 435–439

    Article  CAS  PubMed  Google Scholar 

  • Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, Derksen RH, De Groot PG, Koike T, Meroni PL, Reber G, Shoenfeld Y, Tincani A, Vlachoyiannopoulos PG, Krilis SA (2006) International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 4: 295–306

    Article  CAS  PubMed  Google Scholar 

  • Mutlu I, Mutlu MF, Biri A, Bulut B, Erdem M, Erdem A (2015) Effects of anticoagulant therapy on pregnancy outcomes in patients with thrombophilia and previous poor obstetric history. Blood Coagul Fibrinolysis 26: 267–273

    Article  CAS  PubMed  Google Scholar 

  • Rai R, Cohen H, Dave M, Regan L (1997) Randomised controlled trial of aspirin and aspirin plus heparin in pregnant women with recurrent miscarriage associated with phospholipid antibodies (or antiphospholipid antibodies). BMJ 314: 253–257

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rawlinson WD, Hall B, Jones CA, Jeffery HE, Arbuckle SM, Graf N, Howard J, Morris JM (2008) Viruses and other infections in stillbirth: what is the evidence and what should we be doing? Pathology 40: 149–160

    Article  CAS  PubMed  Google Scholar 

  • Rey E, Kahn SR, David M, Shrier I (2003) Thrombophilic disorders and fetal loss: a meta-analysis. Lancet 361: 901–908

    Article  PubMed  Google Scholar 

  • Rimon E, Ascher-Landsberg J, Carmi N, Many A, Deutsch V, Kupferminc MJ (2012) Severe pregnancy complications are associated with elevated factor VIII plasma activity. Blood Coagul Fibrinolysis 23: 184–188

    Article  CAS  PubMed  Google Scholar 

  • Robertson L, Wu O, Langhorne P, Twaddle S, Clark P, Lowe GD, Walker ID, Greaves M, Brenkel I, Regan L, Greer IA (2006) The Thrombosis: Risk and Economic Assessment of Thrombophilia Screening (TREATS) study. Thrombophilia in pregnancy: a systematic review. Br J Haematol 132: 171–196

    Article  CAS  PubMed  Google Scholar 

  • Rodger MA, Carrier M, Le Gal G, Martinelli I, Perna A, Rey E, de Vries JI, Gris JC (2014) Meta-analysis of low-molecular-weight heparin to prevent recurrent placenta-mediated pregnancy complications. Blood 123: 822–828

    Article  CAS  PubMed  Google Scholar 

  • Rodger MA, Hague WM, Kingdom J, Kahn SR, Karovitch A, Sermer M, Clement AM, Coat S, Chan WS, Said J, Rey E, Robinson S, Khurana R, Demers C, Kovacs MJ, Solymoss S, Hinshaw K, Dwyer J, Smith G, McDonald S, Newstead-Angel J, McLeod A, Khandelwal M, Silver RM, Le Gal G, Greer IA, Keely E, Rosene-Montella K, Walker M, Wells PS (2014) Antepartum dalteparin versus no antepartum dalteparin for the prevention of pregnancy complications in pregnant women with thrombophilia (TIPPS): a multinational open-label randomised trial. Lancet 384: 1673–1683

    Article  CAS  PubMed  Google Scholar 

  • Rogenhofer N, Bohlmann MK, Beuter-Winkler P, Würfel W, Rank A, Thaler CJ, Toth B (2014) Prevention, management and extent of adverse pregnancy outcomes in women with hereditary Antithrombin deficiency. Ann Hematol 93: 385–392

    Article  CAS  PubMed  Google Scholar 

  • Silver RM (2007) Fetal death. Obstet Gynecol 109: 153–167

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Bohlmann, M.K. (2017). Gerinnungsphysiologie bei Totgeburten. In: Toth, B. (eds) Fehlgeburten Totgeburten Frühgeburten. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-50424-6_42

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-50424-6_42

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-50423-9

  • Online ISBN: 978-3-662-50424-6

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics