Skip to main content
SpringerLink
Log in

Idiopathische rezidivierende Aborte

  • Chapter
  • First Online:
Fehlgeburten Totgeburten Frühgeburten

  • 4385 Accesses

Zusammenfassung

Der Spontanabort ist die häufigste Komplikation der Frühschwangerschaft. Er wird meist durch zytogenetische Anomalien verursacht. Das Risiko eines Spontanaborts ist vor allem vom mütterlichen Alter abhängig. Idiopathische rezidivierende Spontanaborte (iRSA) werden diagnostiziert, wenn die Ursachen für rezidivierende Spontanaborte (RSA) unbekannt sind. Es kann derzeit keine Empfehlung für eine Standardtherapie bei iRSA ausgesprochen werden.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 64.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 84.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Literatur

  • American College of Obstetricians and Gynecologists (2002) ACOG Practice Bulletin. Management of recurrent pregnancy loss. Int J Gynaecol Obstet 78(2): 179–190

    Article  Google Scholar 

  • American Society for Reproductive Medicine (ASRM) Practice Committee of the American Society for Reproductive Medicine (2012) Evaluation and treatment of recurrent pregnancy loss: a committee opinion. Fertil Steril 98(5): 1103–1111

    Article  Google Scholar 

  • Andersen AN, Wohlfahrt J, Christens P, Olsen J, Melbye M (2000) Maternal age and fetal loss: population based register linkage study. Brit Med J 320: 1708–1712

    Article  PubMed Central  Google Scholar 

  • Barnhart KT, Sammel M, Rinaudo PF, Zhou L, Hummel AC, Guo W (2004) Symptomatic patients with an early viable intrauterine pregnancy – hCG curves redefined. Obstet Gynecol 104: 50–55

    Article  PubMed  Google Scholar 

  • Boklage CE (1990) Survival probability of human conceptions from fertilization to term. Int J Fertil 35: 75–94

    CAS  PubMed  Google Scholar 

  • Carmichael SL (2013) Hypospadias and maternal intake of phytoestrogens. Am J Epidemiol 178(3): 434–440

    Article  PubMed  PubMed Central  Google Scholar 

  • Carrington B, Sacks G, Regan L (2005) Recurrent miscarriage: pathophysiology and outcome. Curr Opin Obstet Gynecol 17(6): 591–597

    Article  PubMed  Google Scholar 

  • Check JH (2012) The use of heparin for preventing miscarriage. Am J Reprod Immunol 67(4): 326–333

    Article  CAS  PubMed  Google Scholar 

  • Clifford K, Rai R, Regan L (1997) Future pregnancy outcome in unexplained recurrent first trimester miscarriage. Human Reproduction 12(2): 387–389

    Article  CAS  PubMed  Google Scholar 

  • Coomarasamy A, Truchanowicz EG, Rai R (2011) Does first trimester progesterone prophylaxis increase the live birth rate in women with unexplained recurrent miscarriages? BMJ 342: 1914

    Article  Google Scholar 

  • Coomarasamy A, Williams H, Truchanowicz E, Seed PT, Small R, Quenby S, Gupta P, Dawood F, Koot YE, Bender Atik R, Bloemenkamp KW, Brady R, Briley AL, Cavallaro R, Cheong YC, Chu JJ, Eapen A, Ewies A, Hoek A, Kaaijk EM, Koks CA, Li TC, MacLean M, Mol BW, Moore J, Ross JA, Sharpe L, Stewart J, Vaithilingam N, Farquharson RG, Kilby MD, Khalaf Y, Goddijn M, Regan L, Rai R (2015) A randomized trial of progesterone in women with recurrent miscarriages. N Engl J Med 373(22): 2141–2148

    Article  CAS  PubMed  Google Scholar 

  • Fawzy M (2008) Treatment options and pregnancy outcome in women with idiopathic recurrent miscarriage: a randomized placebo-controlled study. Arch Gynecol Obstet 278(1): 33–38

    Article  CAS  PubMed  Google Scholar 

  • Field K, Murphy DJ (2015) Perinatal outcomes in a subsequent pregnancy among women who have experienced recurrent miscarriage: a retrospective cohort study. Hum Reprod 30: 1239

    Article  CAS  PubMed  Google Scholar 

  • Gerhard I, Daniel F, Runnebaum B (1996) Habitueller Abort. Gynäkol Prax 20: 13–24

    Google Scholar 

  • Goetzl L, Krantz D, Simpson JL, Silver RK, Zachary JM (2004) Pregnancy-associated plasma protein A, free ß-hCG, nuchal translucency, and risk of pregnancy loss. Obstetrics Gynecol 104: 30–36

    Article  CAS  Google Scholar 

  • Gris JC (2011) LMWH have no place in recurrent pregnancy loss: debate-against the motion. Thromb Res 127 (suppl 3): S110–112

    Article  Google Scholar 

  • Harger JH, Archer DF, Marchese SG (1983) Etiology of recurrent pregnancy losses and outcome of subsequent pregnancies. Obstet Gynecol 62: 574

    CAS  PubMed  Google Scholar 

  • Hsu, LYF (1998) Prenatal diagnosis of chromosomal abnormalities through amniocentesis. In: Milunsky A (ed) Genetic disorders and the fetus. Johns Hopkins University Press, Baltimore, p. 179

    Google Scholar 

  • Jauniaux E (2006) Evidence-based guidelines for the investigation and medical treatment of recurrent miscarriage. Hum Reprod 21(9): 2216–2222

    Article  PubMed  Google Scholar 

  • Jeng GT, Scott JR, Burmeister LF (1995) A comparison of meta-analytic results using literature vs individual patient data. Paternal cell immunization for recurrent miscarriage.JAMA 274(10): 830–836

    Article  CAS  PubMed  Google Scholar 

  • Jivraj S, Anstie B, Cheong YC (2001) Obstetric and neonatal outcome in women with a history of recurrent miscarriage: a cohort study. Hum Reprod 16: 102

    Article  CAS  PubMed  Google Scholar 

  • de Jong PG, Goddijn M, Middeldorp S (2013) Antithrombotic therapy for pregnancy loss. Hum Reprod Update 19(6): 656–673

    Article  PubMed  Google Scholar 

  • Kaandorp S (2009) Aspirin or anticoagulants for treating recurrent miscarriage in women without antiphospholipid syndrome. Cochrane Database Syst Rev 1: CD004734

    PubMed  Google Scholar 

  • Kaandorp S (2010) Aspirin plus heparin or aspirin alone in women with recurrent miscarriage. N Engl J Med 362(17): 1586–1589

    Article  CAS  PubMed  Google Scholar 

  • Liddell HS, Pattison NS, and Zanderigo A (1991) Recurrent miscarriage - outcome after supportive care in early pregnancy. Aust N Z J Obstet Gynaecol 31(4): 320–322

    Article  CAS  PubMed  Google Scholar 

  • McCracken SA (1999) Gestational regulation of granulocyte-colony stimulating factor receptor expression in the human placenta. Biol Reprod 60(4): 790–796

    Article  CAS  PubMed  Google Scholar 

  • Musters AM (2013) Supportive care for women with recurrent miscarriage: a survey to quantify women′s preferences. Hum Reprod 28(2): 398–405

    Article  CAS  PubMed  Google Scholar 

  • Nybo Andersen AM, Wohlfahrt J, Christens P (2000) Maternal age and fetal loss: population based register linkage study. BMJ 320: 1708

    Article  CAS  PubMed  Google Scholar 

  • Ogasawara M, Aoki K, Okada S, Suzumori K (2000) Embryonic karyotype of abortuses in relation to the number of previous miscarriages.Fertil Steril 73(2): 300–304

    Article  CAS  PubMed  Google Scholar 

  • Osborn JF, Cattaruzza MS, Spinelli A (2000) Risk of spontaneous abortion in Italy, 1978-1995, and the effect of maternal age, gravidity, marital status, and education. Am J Epidemiol 151: 98

    Article  CAS  PubMed  Google Scholar 

  • Philipp T, Philipp K, Reiner A, Beer F, Kalousek DK (2003) Embryoscopic and cytogenetic analysis of 233 missed abortions: factors involved in the pathogenesis of developmental defects of early failed pregnancies. Hum Reprod 18(8): 1724–1732

    Article  CAS  PubMed  Google Scholar 

  • Regan L, Rai R (2000) Epidemiology and the medical causes of miscarriage. Baillieres Best Pract Res Clin Obstet Gynaecol 14: 839

    Article  CAS  PubMed  Google Scholar 

  • Royal College of Obstetricians and Gynaecologists (RCOG) (2011) Recurrent Miscarriage, Investigation and Treatment of Couples (Green-top Guideline No. 17). https://www.rcog.org.uk/en/guidelines-research-services/guidelines/gtg17 (Zugriff: 30.08.2015)

  • Santjohanser C (2013) Granulocyte-colony stimulating factor as treatment option in patients with recurrent miscarriage. Arch Immunol Ther Exp 61(2): 159–164

    Article  CAS  Google Scholar 

  • Saravelos SH, Li TC (2012) Unexplained recurrent miscarriage: how can we explain it? Human Reproduction 27(7): 1882–1886

    Article  PubMed  Google Scholar 

  • Scarpellini F, Sbracia M (2009) Use of granulocyte colony-stimulating factor for the treatment of unexplained recurrent miscarriage: a randomised controlled trial. Hum Reprod 24(11): 2703–2708

    Article  CAS  PubMed  Google Scholar 

  • Scott JR (1994) Recurrent miscarriage: overview and recommendations. Clin Obstet Gynecol 37: 768

    Article  CAS  PubMed  Google Scholar 

  • Scott JR, Pattison N (2000) Human chorionic gonadotrophin for recurrent miscarriage. Cochrane Database Syst Rev 2: CD000101

    PubMed  Google Scholar 

  • Schleussner E, Kamin G, Seliger G, Rogenhofer N, Ebner S, Toth B, Schenk M, Henes M, Bohlmann MK, Fischer T, Brosteanu O, Bauersachs R, Petroff D; ETHIG II group (2015) Low-molecular-weight heparin for women with unexplained recurrent pregnancy loss: a multicenter trial with a minimization randomization scheme. Ann Intern Med 162(9): 601–609

    Article  PubMed  Google Scholar 

  • Stray-Pedersen B, Stray-Pedersen S (1984) Etiologic factors and subsequent reproductive performance in 195 couples with a prior history of habitual abortion. Am J Obstet Gynecol 148(2): 140–146

    Article  CAS  PubMed  Google Scholar 

  • Stray-Pedersen B, Stray-Pedersen S (1988) Recurrent abortion: The role of psychotherapy. In: Beard R, Sharp F (eds.) Early pregnancy loss. Mechanisms and treatment. Springer, Heidelberg, p. 433–440

    Chapter  Google Scholar 

  • Tempfer CB, Kurz C, Bentz EK, Unfried G, Walch K, Czizek U, Huber JC (2006) A combination treatment of prednisone, aspirin, folate, and progesterone in women with idiopathic recurrent miscarriage: a matched-pair study. Fertil Steril 86(1): 145–148

    Article  CAS  PubMed  Google Scholar 

  • Toth B et al.; Deutsche Gesellschaft für Gynäkologie und Geburtshilfe (DGGG) und Arbeitsgemeinschaft Immunologie in der Gynäkologie und Geburtshilfe (AGIM) (2014) Diagnostik und Therapie beim wiederholten Spontanabort. AWMF-Leitlinie 015/050. http://www.awmf.org/uploads/tx_szleitlinien/015-050k_S1_Spontanabort_Diagnostik_Therapie_2014-05.pdf (Zugriff: 30.08.2015)

  • Wallace EM, Marjono B, Tyzack K, Tong S (2004) First trimester levels of inhibins and activin A in normal and failing pregnancies. Clin Endocrinol 60: 484–490

    Article  CAS  Google Scholar 

  • Wang X, Chen C, Wang L (2003) Conception, early pregnancy loss, and time to clinical pregnancy: a population-based prospective study. Fertil Steril 79: 577

    Article  PubMed  Google Scholar 

  • Wilcox AJ, Weinberg CR, O´Connor JF, Baird DD, Schlatterer JP (1988) Incidence of early loss of prgnancy. N Engl J Med 319: 189–194

    Article  CAS  PubMed  Google Scholar 

  • World Health Organization (WHO) (1977) Recommended definitions, terminology and format for statistical tables related to the perinatal period and use of a new certificate for cause of perinatal deaths. Modifications recommended by FIGO as amended October 14, 1976. Acta Obstet Gynecol Scand 56(3): 247–253

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Marienhospital Herne, Frauenklinik, Hölkeskampring 40, 44625, Herne, Deutschland

    Clemens Tempfer

Authors
  1. Clemens Tempfer
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Gynäkologische Endokrinologie und Reproduktionsmedizin, Medizinische Universität Innsbruck, Innsbruck, Austria

    Bettina Toth

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Tempfer, C. (2017). Idiopathische rezidivierende Aborte. In: Toth, B. (eds) Fehlgeburten Totgeburten Frühgeburten. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-50424-6_19

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-50424-6_19

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-50423-9

  • Online ISBN: 978-3-662-50424-6

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation