Zusammenfassung
Etwa ein Viertel aller Frauen im reproduktionsfähigen Alter erlebt mindestens einen Abort. Als weitaus häufigste Ursache für Frühaborte sind spontan entstandene chromosomale Störungen zu nennen. Darüber hinaus können anatomische Fehlbildungen, endokrine, mikrobiologische sowie Umwelt- und Ernährungsfaktoren bei der Pathogenese eine Rolle spielen. Im folgenden Kapitel werden Empfehlungen zu Diagnostik und leitliniengerechter Therapie bei Spontanaborten zusammengefasst.
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Literatur
Andersen AM, Andersen PK, Olsen J, Gronbaek M, Strandberg-Larsen K (2012) Moderate alcohol intake during pregnancy and risk of fetal death. Int J Epidemiol 41: 405–413
Banderali G, Martelli A, Landi M, Moretti F, Betti F, Radaelli G, Lassandro C, Verduci E (2015) Short and long term health effects of parental tobacco smoking during pregnancy and lactation: a descriptive review. Journal of Translational Medicine 13: 327
Barnhart KT, Sammel MD, Rinaudo PF, Zhou L, Hummel AC, Guo W (2004) Symptomatic patients with an early viable intrauterine pregnancy: HCG curves redefined. Obstetrics and Gynecology 104: 50–55
Bech BH, Nohr EA, Vaeth M, Henriksen TB, Olsen J (2005) Coffee and fetal death: a cohort study with prospective data. Am J Epidemiol 162: 983–990
van den Berg MM, van Maarle MC, van Wely M, Goddijn M (2012) Genetics of early miscarriage. Biochim Biophys Acta 1822: 1951–1959
Boklage CE (1990) Survival probability of human conceptions from fertilization to term. International Journal of Fertility 35: 79–80, 81–94
Boots C, Stephenson MD (2011) Does obesity increase the risk of miscarriage in spontaneous conception: a systematic review. Semin Reprod Med 29: 507–513
Carvalho B, Doria S, Ramalho C, Brandao O, Sousa M, Matias A, Barros A, Carvalho F (2010) Aneuploidies detection in miscarriages and fetal deaths using multiplex ligation-dependent probe amplification: an alternative for speeding up results? Eur J Obstet Gynecol Reprod Biol 153: 151–155
Choi TY, Lee HM, Park WK, Jeong SY, Moon HS (2014) Spontaneous abortion and recurrent miscarriage: A comparison of cytogenetic diagnosis in 250 cases. Obstet Gynecol Sci 57: 518–525
Cogendez E, Dolgun ZN, Sanverdi I, Turgut A, Eren S (2011) Post-abortion hysteroscopy: a method for early diagnosis of congenital and acquired intrauterine causes of abortions. Eur J Obstet Gynecol Reprod Biol 156: 101–104
Goddijn M, Leschot NJ (2000) Genetic aspects of miscarriage. Baillieres Best Pract Res Clin Obstet Gynaecol 14: 855–865
Grimbizis G, Camus M, Clasen K, Tournaye H, De Munck L, Devroey P (1998). Hysteroscopic septum resection in patients with recurrent abortions or infertility. Hum Reprod 13: 1188–1193
Kwak-Kim J, Agcaoili MS, Aleta L, Liao A, Ota K, Dambaeva S, Beaman K, Kim JW, Gilman-Sachs A (2013) Management of women with recurrent pregnancy losses and antiphospholipid antibody syndrome. American Journal of Reproductive Immunology 69: 596–607
Larsen EC, Christiansen OB, Kolte AM, Macklon N (2013) New insights into mechanisms behind miscarriage. BMC Med 11: 154
McDonald HM, Chambers HM (2000) Intrauterine infection and spontaneous midgestation abortion: is the spectrum of microorganisms similar to that in preterm labor? Infect Dis Obstet Gynecol 8: 220–227
McNamee KM, Dawood F, Farquharson RG (2014) Mid-trimester pregnancy loss. Obstet Gynecol Clin North Am 41: 87–102
Metwally M, Ong KJ, Ledger WL, Li TC (2008) Does high body mass index increase the risk of miscarriage after spontaneous and assisted conception? A meta-analysis of the evidence. Fertil Steril 90: 714–726
Mollo A, De Franciscis P, Colacurci N, Cobellis L, Perino A, Venezia R, Alviggi C, De Placido G (2009) Hysteroscopic resection of the septum improves the pregnancy rate of women with unexplained infertility: a prospective controlled trial. Fertil Steril 91: 2628–2631
Morris JK, Wald NJ, Watt HC (1999) Fetal loss in Down syndrome pregnancies. Prenat Diagn 19: 142–145
Neilson JP, Gyte GM, Hickey M, Vazquez JC, Dou L (2013) Medical treatments for incomplete miscarriage. The Cochrane Database of Systematic Reviews 3: Cd007223
Nybo Andersen AM, Wohlfahrt J, Christens P, Olsen J, Melbye M (2000) Maternal age and fetal loss: population based register linkage study. BMJ 320: 1708–1712
Philipp T, Philipp K, Reiner A, Beer F, Kalousek DK (2003) Embryoscopic and cytogenetic analysis of 233 missed abortions: factors involved in the pathogenesis of developmental defects of early failed pregnancies. Hum Reprod 18: 1724–1732
Rand JH, Wolgast LR (2012) Dos and don′ts in diagnosing antiphospholipid syndrome. Hematology 2012: 455–459
Saravelos SH, Regan L (2011) The importance of preconception counseling and early pregnancy monitoring. Semin Reprod Med 29: 557–568
Toth B, Würfel W, Bohlmann MK, Gillessen-Kaesbach G, Nawroth F, Rogenhofer N, Tempfer C, Wischmann T, von Wolff M (2013) S1-Leitlinie: Diagnostik und Therapie beim wiederholten Spontanabort (aktueller Stand: 12/2013)
Twig G, Shina A, Amital H, Shoenfeld Y (2012) Pathogenesis of infertility and recurrent pregnancy loss in thyroid autoimmunity. J Autoimmun 38: J275–281
Wang S, Shi X, Hua X, Gu X, Yang D (2013) Hysteroscopic transcervical resection of uterine septum. JSLS 17: 517–520
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Knieper, C. (2017). Diagnostik und Therapie bei sporadischen Fehlgeburten. In: Toth, B. (eds) Fehlgeburten Totgeburten Frühgeburten. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-50424-6_11
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