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Benign and Malignant Lymphoid Lesions of the Head and Neck

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Abstract

In this chapter, we review the benign and malignant lymphoid proliferative lesions that frequently originate or secondarily involve the lymph nodes and extranodal sites of the head and neck. They are a broad and heterogeneous group of diseases, and therefore a general outlook for their diagnoses, integrating clinical information together with morphology, phenotypic and molecular studies, as well as useful bibliographic references, is provided. Additional macroscopic and microscopic representative images of the entities discussed are included.

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References

  1. Quinones-Avila MP, Gonzalez-Longoria AA, Admirand JH, et al. Hodgkin lymphoma involving Waldeyer ring: a clinicopathologic study of 22 cases. Am J Clin Pathol. 2005;123:651–6.

    Article  Google Scholar 

  2. Swerdlow SH, Campo E, Harris NL, et al. WHO classification of tumors of hematopoietic and lymphoid tissues. Lyon, France: IARC Press: 2008.

    Google Scholar 

  3. Attygalle AD, Liu H, Shirali S, et al. Atypical marginal zone hyperplasia of mucosa-associated lymphoid tissue: a reactive condition of childhood showing immunoglobulin lambda light-chain restriction. Blood. 2004;104:3343–8.

    Article  CAS  PubMed  Google Scholar 

  4. Kaur P, Levy NB. Atypical marginal zone hyperplasia of tonsil with immunoglobulin light chain restriction. Am J Hematol. 2012;87:424–5.

    Article  PubMed  Google Scholar 

  5. Bailey RE. Diagnosis and treatment of infectious mononucleosis. Am Fam Physician. 1994;49:879–88.

    CAS  PubMed  Google Scholar 

  6. Lukes RJ, Tindle BH, Parker JW. Reed-Sternberg-like cells in infectious mononucleosis. Lancet. 1969;2:1003–4.

    Article  CAS  PubMed  Google Scholar 

  7. Anagnostopoulos I, Hummel M, Falini B, et al. Epstein-barr virus infection of monocytoid B-cell proliferates: an early feature of primary viral infection? Am J Surg Pathol. 2005;29:595–601.

    Article  PubMed  Google Scholar 

  8. Niedobitek G, Herbst H, Young LS, et al. Patterns of Epstein-Barr virus infection in non-neoplastic lymphoid tissue. Blood. 1992;79:2520–6.

    CAS  PubMed  Google Scholar 

  9. Salvador AH, Harrison Jr EG, Kyle RA. Lymphadenopathy due to infectious mononucleosis: its confusion with malignant lymphoma. Cancer. 1971;27:1029–40.

    Article  CAS  PubMed  Google Scholar 

  10. Jenson HB. Virologic diagnosis, viral monitoring, and treatment of Epstein-Barr virus infectious mononucleosis. Curr Infect Dis Rep. 2004;6:200–7.

    Article  PubMed  Google Scholar 

  11. Luzuriaga K, Sullivan JL. Infectious mononucleosis. N Engl J Med. 2010;362:1993–2000.

    Article  CAS  PubMed  Google Scholar 

  12. Gaffey MJ, Ben-Ezra JM, Weiss LM. Herpes simplex lymphadenitis. Am J Clin Pathol. 1991;95:709–14.

    Article  CAS  PubMed  Google Scholar 

  13. Howat AJ, Campbell AR, Stewart DJ. Generalized lymphadenopathy due to herpes simplex virus type I. Histopathology. 1991;19:563–4.

    Article  CAS  PubMed  Google Scholar 

  14. Joubert M, Morin C, Moreau A, et al. Histopathologic features of cytomegalovirus lymphadenitis in the “immunocompetent” patient. Report of 7 cases. Ann Pathol. 1996;16:254–60.

    CAS  PubMed  Google Scholar 

  15. Rushin JM, Riordan GP, Heaton RB, et al. Cytomegalovirus-infected cells express Leu-M1 antigen. A potential source of diagnostic error. Am J Pathol. 1990;136:989–95.

    CAS  PubMed  PubMed Central  Google Scholar 

  16. Shahab I, Osborne BM, Butler JJ. Nasopharyngeal lymphoid tissue masses in patients with human immunodeficiency virus-1. Histologic findings and clinical correlation. Cancer. 1994;74:3083–8.

    Article  CAS  PubMed  Google Scholar 

  17. Ioachim HL, Cronin W, Roy M, et al. Persistent lymphadenopathies in people at high risk for HIV infection. Clinicopathologic correlations and long-term follow-up in 79 cases. Am J Clin Pathol. 1990;93:208–18.

    Article  CAS  PubMed  Google Scholar 

  18. O’Murchadha MT, Wolf BC, Neiman RS. The histologic features of hyperplastic lymphadenopathy in AIDS-related complex are nonspecific. Am J Surg Pathol. 1987;11:94–9.

    Article  PubMed  Google Scholar 

  19. Alos L, Navarrete P, Morente V, et al. Immunoarchitecture of lymphoid tissue in HIV-infection during antiretroviral therapy correlates with viral persistence. Mod Pathol. 2005;18:127–36.

    Article  CAS  PubMed  Google Scholar 

  20. Leung AK, Robson WL. Childhood cervical lymphadenopathy. J Pediatr Health Care. 2004;18:3–7.

    Article  PubMed  Google Scholar 

  21. Yamauchi T, Ferrieri P, Anthony BF. The etiology of acute cervical adenitis in children: serological and bacteriological studies. J Med Microbiol. 1980;13:37–43.

    Google Scholar 

  22. Dauga C, Miras I, Grimont PA. Identification of Bartonella henselae and B. quintana 16s rDNA sequences by branch-, genus- and species-specific amplification. J Med Microbiol. 1996;45:192–9.

    Article  CAS  PubMed  Google Scholar 

  23. Lamps LW, Scott MA. Cat-scratch disease: historic, clinical, and pathologic perspectives. Am J Clin Pathol. 2004;121(Suppl):S71–80.

    PubMed  Google Scholar 

  24. Wear DJ, Margileth AM, Hadfield TL, et al. Cat scratch disease: a bacterial infection. Science. 1983;221:1403–5.

    Article  CAS  PubMed  Google Scholar 

  25. Bem C, Patil PS, Bharucha H, et al. Importance of human immunodeficiency virus-associated lymphadenopathy and tuberculous lymphadenitis in patients undergoing lymph node biopsy in Zambia. Br J Surg. 1996;83:75–8.

    Article  CAS  PubMed  Google Scholar 

  26. Sibanda EN, Stanczuk G. Lymph node pathology in Zimbabwe: a review of 2194 specimens. Q J Med. 1993;86:811–7.

    CAS  PubMed  Google Scholar 

  27. Falzon D, it-Belghiti F. What is tuberculosis surveillance in the European Union telling us? Clin Infect Dis. 2007;44:1261–7.

    Article  PubMed  Google Scholar 

  28. Newton SM, Brent AJ, Anderson S, et al. Paediatric tuberculosis. Lancet Infect Dis. 2008;8:498–510.

    Article  PubMed  Google Scholar 

  29. Bayazit YA, Bayazit N, Namiduru M. Mycobacterial cervical lymphadenitis. ORL J Otorhinolaryngol Relat Spec. 2004;66:275–80.

    Article  PubMed  Google Scholar 

  30. Penfold CN, Revington PJ. A review of 23 patients with tuberculosis of the head and neck. Br J Oral Maxillofac Surg. 1996;34:508–10.

    Article  CAS  PubMed  Google Scholar 

  31. Ammari FF, Bani Hani AH, Ghariebeh KI. Tuberculosis of the lymph glands of the neck: a limited role for surgery. Otolaryngol Head Neck Surg. 2003;128:576–80.

    Article  PubMed  Google Scholar 

  32. McCabe RE, Brooks RG, Dorfman RF, et al. Clinical spectrum in 107 cases of toxoplasmic lymphadenopathy. Rev Infect Dis. 1987;9:754–74.

    Article  CAS  PubMed  Google Scholar 

  33. Lin MH, Kuo TT. Specificity of the histopathological triad for the diagnosis of toxoplasmic lymphadenitis: polymerase chain reaction study. Pathol Int. 2001;51:619–23.

    Article  CAS  PubMed  Google Scholar 

  34. Montoya JG, Remington JS. Studies on the serodiagnosis of toxoplasmic lymphadenitis. Clin Infect Dis. 1995;20:781–9.

    Article  CAS  PubMed  Google Scholar 

  35. Kluin PM, Langerak AW, Beverdam-Vincent J, et al. Paediatric nodal marginal zone B-cell lymphadenopathy of the neck: a Haemophilus influenzae-driven immune disorder? J Pathol. 2015;236:302–14.

    Article  CAS  PubMed  Google Scholar 

  36. Fox RA, Rosahn PD. The lymph nodes in disseminated lupus erythematosus. Am J Pathol. 1943;19:73–99.

    CAS  PubMed  PubMed Central  Google Scholar 

  37. Shapira Y, Weinberger A, Wysenbeek AJ. Lymphadenopathy in systemic lupus erythematosus. Prevalence and relation to disease manifestations. Clin Rheumatol. 1996;15:335–8.

    Article  CAS  PubMed  Google Scholar 

  38. Kojima M, Motoori T, Asano S, et al. Histological diversity of reactive and atypical proliferative lymph node lesions in systemic lupus erythematosus patients. Pathol Res Pract. 2007;203:423–31.

    Article  PubMed  Google Scholar 

  39. Medeiros LJ, Kaynor B, Harris NL. Lupus lymphadenitis: report of a case with immunohistologic studies on frozen sections. Hum Pathol. 1989;20:295–9.

    Article  CAS  PubMed  Google Scholar 

  40. Chen YF, Zhang WD, Sun CZ, et al. Clinical features and outcomes of head and neck castleman disease. J Oral Maxillofac Surg. 2012;70:2466–79.

    Article  PubMed  Google Scholar 

  41. Song JJ, Jung MH, Woo JS, et al. Castleman’s disease of the head and neck. Eur Arch Otorhinolaryngol. 2006;263:160–3.

    Article  PubMed  Google Scholar 

  42. Rabinowitz MR, Levi J, Conard K, et al. Castleman disease in the pediatric neck: a literature review. Otolaryngol Head Neck Surg. 2013;148:1028–36.

    Article  PubMed  Google Scholar 

  43. Fujimoto Y, Kojima Y, Yamaguchi K. Cervical necrotizing lymphadenitis, a new clinicopathological agent. Naika. 1972;20:920–7.

    Google Scholar 

  44. Kikuchi M. Lymphadenitis showing focal reticulum cell hyperplasia with nuclear debris and phagocytosis. Nippon Ketsueki Gakkai Zasshi. 1972;35:379–80.

    Google Scholar 

  45. Bosch X, Guilabert A, Miquel R, et al. Enigmatic Kikuchi-Fujimoto disease: a comprehensive review. Am J Clin Pathol. 2004;122:141–52.

    Article  PubMed  Google Scholar 

  46. Dorfman RF. Histiocytic necrotizing lymphadenitis of Kikuchi and Fujimoto. Arch Pathol Lab Med. 1987;111:1026–9.

    CAS  PubMed  Google Scholar 

  47. Dorfman RF, Berry GJ. Kikuchi’s histiocytic necrotizing lymphadenitis: an analysis of 108 cases with emphasis on differential diagnosis. Semin Diagn Pathol. 1988;5:329–45.

    CAS  PubMed  Google Scholar 

  48. Spies J, Foucar K, Thompson CT, et al. The histopathology of cutaneous lesions of Kikuchi’s disease (necrotizing lymphadenitis): a report of five cases. Am J Surg Pathol. 1999;23:1040–7.

    Article  CAS  PubMed  Google Scholar 

  49. Yasukawa K, Matsumura T, Sato-Matsumura KC, et al. Kikuchi’s disease and the skin: case report and review of the literature. Br J Dermatol. 2001;144:885–9.

    Article  CAS  PubMed  Google Scholar 

  50. Kuo TT. Kikuchi’s disease (histiocytic necrotizing lymphadenitis). A clinicopathologic study of 79 cases with an analysis of histologic subtypes, immunohistology, and DNA ploidy. Am J Surg Pathol. 1995;19:798–809.

    Article  CAS  PubMed  Google Scholar 

  51. Chamulak GA, Brynes RK, Nathwani BN. Kikuchi-Fujimoto disease mimicking malignant lymphoma. Am J Surg Pathol. 1990;14:514–23.

    Article  CAS  PubMed  Google Scholar 

  52. Chan JK, Kwong YL. Common misdiagnoses in lymphomas and avoidance strategies. Lancet Oncol. 2010;11:579–88.

    Article  PubMed  Google Scholar 

  53. Goldblatt F, Andrews J, Russell A, et al. Association of Kikuchi-Fujimoto’s disease with SLE. Rheumatology (Oxford). 2008;47:553–4.

    Article  CAS  Google Scholar 

  54. Martinez-Vazquez C, Hughes G, Bordon J, et al. Histiocytic necrotizing lymphadenitis, Kikuchi-Fujimoto’s disease, associated with systemic lupus erythemotosus. QJM. 1997;90:531–3.

    Article  CAS  PubMed  Google Scholar 

  55. Rosai J, Dorfman RF. Sinus histiocytosis with massive lymphadenopathy. A newly recognized benign clinicopathological entity. Arch Pathol. 1969;87:63–70.

    CAS  PubMed  Google Scholar 

  56. Foucar E, Rosai J, Dorfman R. Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): review of the entity. Semin Diagn Pathol. 1990;7:19–73.

    CAS  PubMed  Google Scholar 

  57. Maric I, Pittaluga S, Dale JK, et al. Histologic features of sinus histiocytosis with massive lymphadenopathy in patients with autoimmune lymphoproliferative syndrome. Am J Surg Pathol. 2005;29:903–11.

    Article  PubMed  Google Scholar 

  58. Chen TD, Lee LY. Rosai-Dorfman disease presenting in the parotid gland with features of IgG4-related sclerosing disease. Arch Otolaryngol Head Neck Surg. 2011;137:705–8.

    Article  PubMed  Google Scholar 

  59. Kuo TT, Chen TC, Lee LY, et al. IgG4-positive plasma cells in cutaneous Rosai-Dorfman disease: an additional immunohistochemical feature and possible relationship to IgG4-related sclerosing disease. J Cutan Pathol. 2009;36:1069–73.

    Article  PubMed  Google Scholar 

  60. Hui PK, Chan JK, Ng CS, et al. Lymphadenopathy of Kimura’s disease. Am J Surg Pathol. 1989;13:177–86.

    Article  CAS  PubMed  Google Scholar 

  61. Kuo TT, Shih LY, Chan HL. Kimura’s disease. Involvement of regional lymph nodes and distinction from angiolymphoid hyperplasia with eosinophilia. Am J Surg Pathol. 1988;12:843–54.

    Article  CAS  PubMed  Google Scholar 

  62. Chen H, Thompson LD, Aguilera NS, et al. Kimura disease: a clinicopathologic study of 21 cases. Am J Surg Pathol. 2004;28:505–13.

    Article  PubMed  Google Scholar 

  63. Iyengar P, Mazloom A, Shihadeh F, et al. Hodgkin lymphoma involving extranodal and nodal head and neck sites: characteristics and outcomes. Cancer. 2010;116:3825–9.

    Article  PubMed  Google Scholar 

  64. Goel A, Fan W, Patel AA, et al. Nodular lymphocyte predominant Hodgkin lymphoma: biology, diagnosis and treatment. Clin Lymphoma Myeloma Leuk. 2014;14:261–70.

    Google Scholar 

  65. Anagnostopoulos I, Hansmann ML, Franssila K, et al. European Task Force on Lymphoma project on lymphocyte predominance Hodgkin disease: histologic and immunohistologic analysis of submitted cases reveals 2 types of Hodgkin disease with a nodular growth pattern and abundant lymphocytes. Blood. 2000;96:1889–99.

    CAS  PubMed  Google Scholar 

  66. Hicks J, Flaitz C. Progressive transformation of germinal centers: review of histopathologic and clinical features. Int J Pediatr Otorhinolaryngol. 2002;65:195–202.

    Article  PubMed  Google Scholar 

  67. Pittaluga S, Jaffe ES. T-cell/histiocyte-rich large B-cell lymphoma. Haematologica. 2010;95:352–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  68. Lee AI, LaCasce AS. Nodular lymphocyte predominant Hodgkin lymphoma. Oncologist. 2009;14:739–51.

    Article  PubMed  Google Scholar 

  69. Iguchi H, Wada T, Matsushita N, et al. Anatomic distribution of hematolymphoid malignancies in the head and neck: 7 years of experience with 122 patients in a single institution. Acta Otolaryngol. 2012;132:1224–31.

    Article  PubMed  Google Scholar 

  70. Ott G, Katzenberger T, Lohr A, et al. Cytomorphologic, immunohistochemical, and cytogenetic profiles of follicular lymphoma: 2 types of follicular lymphoma grade 3. Blood. 2002;99:3806–12.

    Article  CAS  PubMed  Google Scholar 

  71. Piccaluga PP, Califano A, Klein U, et al. Gene expression analysis provides a potential rationale for revising the histological grading of follicular lymphomas. Haematologica. 2008;93:1033–8.

    Article  CAS  PubMed  Google Scholar 

  72. Dong HY, Harris NL, Preffer FI, et al. Fine-needle aspiration biopsy in the diagnosis and classification of primary and recurrent lymphoma: a retrospective analysis of the utility of cytomorphology and flow cytometry. Mod Pathol. 2001;14:472–81.

    Article  CAS  PubMed  Google Scholar 

  73. Pappa VI, Hussain HK, Reznek RH, et al. Role of image-guided core-needle biopsy in the management of patients with lymphoma. J Clin Oncol. 1996;14:2427–30.

    CAS  PubMed  Google Scholar 

  74. Horsman DE, Gascoyne RD, Coupland RW, et al. Comparison of cytogenetic analysis, southern analysis, and polymerase chain reaction for the detection of t(14; 18) in follicular lymphoma. Am J Clin Pathol. 1995;103:472–8.

    Article  CAS  PubMed  Google Scholar 

  75. Rowley JD. Chromosome studies in the non-Hodgkin’s lymphomas: the role of the 14;18 translocation. J Clin Oncol. 1988;6:919–25.

    CAS  PubMed  Google Scholar 

  76. Horsman DE, Connors JM, Pantzar T, et al. Analysis of secondary chromosomal alterations in 165 cases of follicular lymphoma with t(14;18). Genes Chromosomes Cancer. 2001;30:375–82.

    Article  CAS  PubMed  Google Scholar 

  77. Viardot A, Barth TF, Moller P, et al. Cytogenetic evolution of follicular lymphoma. Semin Cancer Biol. 2003;13:183–90.

    Article  PubMed  Google Scholar 

  78. Liu Q, Salaverria I, Pittaluga S, et al. Follicular lymphomas in children and young adults: a comparison of the pediatric variant with usual follicular lymphoma. Am J Surg Pathol. 2013;37:333–43.

    Article  PubMed  PubMed Central  Google Scholar 

  79. Schraders M, de Jong D, Kluin P, et al. Lack of Bcl-2 expression in follicular lymphoma may be caused by mutations in the BCL2 gene or by absence of the t(14;18) translocation. J Pathol. 2005;205:329–35.

    Article  CAS  PubMed  Google Scholar 

  80. Ghielmini M, Vitolo U, Kimby E, et al. ESMO Guidelines consensus conference on malignant lymphoma 2011 part 1: diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL) and chronic lymphocytic leukemia (CLL). Ann Oncol. 2013;24:561–76.

    Article  CAS  PubMed  Google Scholar 

  81. Triantafillidou K, Dimitrakopoulos J, Iordanidis F, et al. Extranodal non-hodgkin lymphomas of the oral cavity and maxillofacial region: a clinical study of 58 cases and review of the literature. J Oral Maxillofac Surg. 2012;70:2776–85.

    Article  PubMed  Google Scholar 

  82. Zucca E, Fontana S, Roggero E, et al. Treatment and prognosis of centrocytic (mantle cell) lymphoma: a retrospective analysis of twenty-six patients treated in one institution. Leuk Lymphoma. 1994;13:105–10.

    Article  CAS  PubMed  Google Scholar 

  83. Campo E, Raffeld M, Jaffe ES. Mantle-cell lymphoma. Semin Hematol. 1999;36:115–27.

    CAS  PubMed  Google Scholar 

  84. Mozos A, Royo C, Hartmann E, et al. SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype. Haematologica. 2009;94:1555–62.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  85. Jares P, Colomer D, Campo E. Molecular pathogenesis of mantle cell lymphoma. J Clin Invest. 2012;122:3416–23.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  86. Caballero D, Campo E, Lopez-Guillermo A, et al. Clinical practice guidelines for diagnosis, treatment, and follow-up of patients with mantle cell lymphoma. Recommendations from the GEL/TAMO Spanish Cooperative Group. Ann Hematol. 2013;92:1151–79.

    Article  PubMed  Google Scholar 

  87. Campo E, Cardesa A, Alos L, et al. Non-Hodgkin’s lymphomas of nasal cavity and paranasal sinuses. An immunohistochemical study. Am J Clin Pathol. 1991;96:184–90.

    Article  CAS  PubMed  Google Scholar 

  88. de Leval L, Bonnet C, Copie-Bergman C, et al. Diffuse large B-cell lymphoma of Waldeyer’s ring has distinct clinicopathologic features: a GELA study. Ann Oncol. 2012;23:3143–51.

    Article  PubMed  Google Scholar 

  89. Lopez-Guillermo A, Colomo L, Jimenez M, et al. Diffuse large B-cell lymphoma: clinical and biological characterization and outcome according to the nodal or extranodal primary origin. J Clin Oncol. 2005;23:2797–804.

    Article  PubMed  Google Scholar 

  90. Colomo L, Lopez-Guillermo A, Perales M, et al. Clinical impact of the differentiation profile assessed by immunophenotyping in patients with diffuse large B-cell lymphoma. Blood. 2003;101:78–84.

    Article  CAS  PubMed  Google Scholar 

  91. Gutierrez-Garcia G, Cardesa-Salzmann T, Climent F, et al. Gene-expression profiling and not immunophenotypic algorithms predicts prognosis in patients with diffuse large B-cell lymphoma treated with immunochemotherapy. Blood. 2011;117:4836–43.

    Article  CAS  PubMed  Google Scholar 

  92. Salaverria I, Philipp C, Oschlies I, et al. Translocations activating IRF4 identify a subtype of germinal center-derived B-cell lymphoma affecting predominantly children and young adults. Blood. 2011;118:139–47.

    Article  CAS  PubMed  Google Scholar 

  93. Alizadeh AA, Eisen MB, Davis RE, et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature. 2000;403:503–11.

    Article  CAS  PubMed  Google Scholar 

  94. Rosenwald A, Wright G, Chan WC, et al. The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. N Engl J Med. 2002;346:1937–47.

    Article  PubMed  Google Scholar 

  95. Davis RE, Brown KD, Siebenlist U, et al. Constitutive nuclear factor kappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells. J Exp Med. 2001;194:1861–74.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  96. Lenz G, Wright GW, Emre NC, et al. Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways. Proc Natl Acad Sci U S A. 2008;105:13520–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  97. Salles G, de Jong D, Xie W, et al. Prognostic significance of immunohistochemical biomarkers in diffuse large B-cell lymphoma: a study from the Lunenburg Lymphoma Biomarker Consortium. Blood. 2011;117:7070–8.

    Article  PubMed  CAS  Google Scholar 

  98. Salaverria I, Zettl A, Bea S, et al. Chromosomal alterations detected by comparative genomic hybridization in subgroups of gene expression-defined Burkitt’s lymphoma. Haematologica. 2008;93:1327–34.

    Article  PubMed  Google Scholar 

  99. Vose J, Armitage J, Weisenburger D. International peripheral T-cell and natural killer/T-cell lymphoma study: pathology findings and clinical outcomes. J Clin Oncol. 2008;26:4124–30.

    Article  PubMed  Google Scholar 

  100. de Leval L, Gisselbrecht C, Gaulard P. Advances in the understanding and management of angioimmunoblastic T-cell lymphoma. Br J Haematol. 2010;148:673–89.

    Article  PubMed  CAS  Google Scholar 

  101. Attygalle AD, Chuang SS, Diss TC, et al. Distinguishing angioimmunoblastic T-cell lymphoma from peripheral T-cell lymphoma, unspecified, using morphology, immunophenotype and molecular genetics. Histopathology. 2007;50:498–508.

    Article  CAS  PubMed  Google Scholar 

  102. Ferreri AJ, Govi S, Pileri SA, et al. Anaplastic large cell lymphoma, ALK-positive. Crit Rev Oncol Hematol. 2012;83:293–302.

    Article  PubMed  Google Scholar 

  103. Saygin C, Uzunaslan D, Ozguroglu M, et al. Dendritic cell sarcoma: a pooled analysis including 462 cases with presentation of our case series. Crit Rev Oncol Hematol. 2013;88:253–71.

    Article  PubMed  Google Scholar 

  104. Lee EJ, Hyun DW, Cho HJ, et al. A rare case of interdigitating dendritic cell sarcoma in the nasal cavity. Case Rep Otolaryngol. 2013;2013:913157.

    Google Scholar 

  105. Parada D, Pena KB, Gil I, et al. Interdigitating dendritic cell sarcoma presenting in the nasal region. Pathol Res Pract. 2012;208:368–71.

    Article  PubMed  Google Scholar 

  106. Attard AA, Praveen P, Dunn PJ, et al. Epstein-Barr virus-positive mucocutaneous ulcer of the oral cavity: the importance of having a detailed clinical history to reach a correct diagnosis. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;114:e37–9.

    Article  PubMed  Google Scholar 

  107. Dojcinov SD, Venkataraman G, Raffeld M, et al. EBV positive mucocutaneous ulcer – a study of 26 cases associated with various sources of immunosuppression. Am J Surg Pathol. 2010;34:405–17.

    Article  PubMed  Google Scholar 

  108. McGinness JL, Spicknall KE, Mutasim DF. Azathioprine-induced EBV-positive mucocutaneous ulcer. J Cutan Pathol. 2012;39:377–81.

    Article  PubMed  Google Scholar 

  109. Dojcinov SD, Venkataraman G, Pittaluga S, et al. Age-related EBV-associated lymphoproliferative disorders in the Western population: a spectrum of reactive lymphoid hyperplasia and lymphoma. Blood. 2011;117:4726–35.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  110. Di NA, Giubettini M, Duranti E, et al. Iatrogenic EBV-positive lymphoproliferative disorder with features of EBV+ mucocutaneous ulcer: evidence for concomitant TCRgamma/IGH rearrangements in the Hodgkin-like neoplastic cells. Virchows Arch. 2011;458:631–6.

    Article  Google Scholar 

  111. Hashizume H, Uchiyama I, Kawamura T, et al. Epstein-Barr virus-positive mucocutaneous ulcers as a manifestation of methotrexate-associated B-cell lymphoproliferative disorders. Acta Derm Venereol. 2012;92:276–7.

    Article  PubMed  Google Scholar 

  112. Delecluse HJ, Anagnostopoulos I, Dallenbach F, et al. Plasmablastic lymphomas of the oral cavity: a new entity associated with the human immunodeficiency virus infection. Blood. 1997;89:1413–20.

    CAS  PubMed  Google Scholar 

  113. Valera A, Balague O, Colomo L, et al. IG/MYC rearrangements are the main cytogenetic alteration in plasmablastic lymphomas. Am J Surg Pathol. 2010;34:1686–94.

    PubMed  PubMed Central  Google Scholar 

  114. Castillo J, Pantanowitz L, Dezube BJ. HIV-associated plasmablastic lymphoma: lessons learned from 112 published cases. Am J Hematol. 2008;83:804–9.

    Article  PubMed  Google Scholar 

  115. Foss F. Evolving therapy of peripheral T-cell lymphoma: 2010 and beyond. Ther Adv Hematol. 2011;2:161–73.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  116. Foss FM, Zinzani PL, Vose JM, et al. Peripheral T-cell lymphoma. Blood. 2011;117:6756–67.

    Article  CAS  PubMed  Google Scholar 

  117. Piccaluga PP, Agostinelli C, Tripodo C, et al. Peripheral T-cell lymphoma classification: the matter of cellular derivation. Expert Rev Hematol. 2011;4:415–25.

    Article  PubMed  Google Scholar 

  118. Lu NN, Li YX, Wang WH, et al. Clinical behavior and treatment outcome of primary nasal diffuse large B-cell lymphoma. Cancer. 2012;118:1593–8.

    Article  PubMed  Google Scholar 

  119. Cheung MM, Chan JK, Lau WH, et al. Early stage nasal NK/T-cell lymphoma: clinical outcome, prognostic factors, and the effect of treatment modality. Int J Radiat Oncol Biol Phys. 2002;54:182–90.

    Article  PubMed  Google Scholar 

  120. Yamaguchi M, Kwong YL, Kim WS, et al. Phase II study of SMILE chemotherapy for newly diagnosed stage IV, relapsed, or refractory extranodal natural killer (NK)/T-cell lymphoma, nasal type: the NK-Cell Tumor Study Group study. J Clin Oncol. 2011;29:4410–6.

    Article  CAS  PubMed  Google Scholar 

  121. Yamaguchi M, Tobinai K, Oguchi M, et al. Concurrent chemoradiotherapy for localized nasal natural killer/T-cell lymphoma: an updated analysis of the Japan clinical oncology group study JCOG0211. J Clin Oncol. 2012;30:4044–6.

    Article  PubMed  Google Scholar 

  122. Jaccard A, Gachard N, Marin B, et al. Efficacy of L-asparaginase with methotrexate and dexamethasone (AspaMetDex regimen) in patients with refractory or relapsing extranodal NK/T-cell lymphoma, a phase 2 study. Blood. 2011;117:1834–9.

    Article  CAS  PubMed  Google Scholar 

  123. Koom WS, Chung EJ, Yang WI, et al. Angiocentric T-cell and NK/T-cell lymphomas: radiotherapeutic viewpoints. Int J Radiat Oncol Biol Phys. 2004;59:1127–37.

    Article  PubMed  Google Scholar 

  124. Bhatti RM, Stelow EB. IgG4-related disease of the head and neck. Adv Anat Pathol. 2013;20:10–6.

    Article  CAS  PubMed  Google Scholar 

  125. Geyer JT, Deshpande V. IgG4-associated sialadenitis. Curr Opin Rheumatol. 2011;23:95–101.

    Article  CAS  PubMed  Google Scholar 

  126. Dahlgren M, Khosroshahi A, Nielsen GP, et al. Riedel’s thyroiditis and multifocal fibrosclerosis are part of the IgG4-related systemic disease spectrum. Arthritis Care Res (Hoboken). 2010;62:1312–8.

    Article  Google Scholar 

  127. Li Y, Zhou G, Ozaki T, et al. Distinct histopathological features of Hashimoto’s thyroiditis with respect to IgG4-related disease. Mod Pathol. 2012;25:1086–97.

    Article  PubMed  Google Scholar 

  128. Stone JH, Zen Y, Deshpande V. IgG4-related disease. N Engl J Med. 2012;366:539–51.

    Article  CAS  PubMed  Google Scholar 

  129. Troch M, Formanek M, Streubel B, et al. Clinicopathological aspects of mucosa-associated lymphoid tissue (MALT) lymphoma of the parotid gland: a retrospective single-center analysis of 28 cases. Head Neck. 2011;33:763–7.

    Article  PubMed  Google Scholar 

  130. Jakobiec FA, Knowles DM. An overview of ocular adnexal lymphoid tumors. Trans Am Ophthalmol Soc. 1989;87:420–42.

    Google Scholar 

  131. Johnson TE, Tse DT, Byrne Jr GE, et al. Ocular-adnexal lymphoid tumors: a clinicopathologic and molecular genetic study of 77 patients. Ophthal Plast Reconstr Surg. 1999;15:171–9.

    Article  CAS  PubMed  Google Scholar 

  132. White WL, Ferry JA, Harris NL, et al. Ocular adnexal lymphoma. A clinicopathologic study with identification of lymphomas of mucosa-associated lymphoid tissue type. Ophthalmology. 1995;102:1994–2006.

    Article  CAS  PubMed  Google Scholar 

  133. Alzouebi M, Goepel JR, Horsman JM, et al. Primary thyroid lymphoma: the 40 year experience of a UK lymphoma treatment centre. Int J Oncol. 2012;40:2075–80.

    CAS  PubMed  Google Scholar 

  134. Thieblemont C, Mayer A, Dumontet C, et al. Primary thyroid lymphoma is a heterogeneous disease. J Clin Endocrinol Metab. 2002;87:105–11.

    Article  CAS  PubMed  Google Scholar 

  135. Remstein ED, Dogan A, Einerson RR, et al. The incidence and anatomic site specificity of chromosomal translocations in primary extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) in North America. Am J Surg Pathol. 2006;30:1546–53.

    Article  PubMed  Google Scholar 

  136. Streubel B, Simonitsch-Klupp I, Mullauer L, et al. Variable frequencies of MALT lymphoma-associated genetic aberrations in MALT lymphomas of different sites. Leukemia. 2004;18:1722–6.

    Article  CAS  PubMed  Google Scholar 

  137. Streubel B, Vinatzer U, Lamprecht A, et al. T(3;14)(p14.1;q32) involving IGH and FOXP1 is a novel recurrent chromosomal aberration in MALT lymphoma. Leukemia. 2005;19:652–8.

    CAS  PubMed  Google Scholar 

  138. Chan JK, Ng CS, Isaacson PG. Relationship between high-grade lymphoma and low-grade B-cell mucosa-associated lymphoid tissue lymphoma (MALToma) of the stomach. Am J Pathol. 1990;136:1153–64.

    CAS  PubMed  PubMed Central  Google Scholar 

  139. Ferreri AJ, Guidoboni M, Ponzoni M, et al. Evidence for an association between Chlamydia psittaci and ocular adnexal lymphomas. J Natl Cancer Inst. 2004;96:586–94.

    Article  PubMed  Google Scholar 

  140. Ferreri AJ, Ponzoni M, Guidoboni M, et al. Regression of ocular adnexal lymphoma after Chlamydia psittaci-eradicating antibiotic therapy. J Clin Oncol. 2005;23:5067–73.

    Article  PubMed  Google Scholar 

  141. Ellis GL. Lymphoid lesions of salivary glands: malignant and benign. Med Oral Patol Oral Cir Bucal. 2007;12:E479–85.

    PubMed  Google Scholar 

  142. Dahl IM, Rasmussen T, Kauric G, et al. Differential expression of CD56 and CD44 in the evolution of extramedullary myeloma. Br J Haematol. 2002;116:273–7.

    Article  CAS  PubMed  Google Scholar 

  143. Garcia-Sanz R, Orfao A, Gonzalez M, et al. Primary plasma cell leukemia: clinical, immunophenotypic, DNA ploidy, and cytogenetic characteristics. Blood. 1999;93:1032–7.

    CAS  PubMed  Google Scholar 

  144. Wirk B, Wingard JR, Moreb JS. Extramedullary disease in plasma cell myeloma: the iceberg phenomenon. Bone Marrow Transplant. 2013;48:10–8.

    Article  CAS  PubMed  Google Scholar 

  145. Pileri SA, Ascani S, Cox MC, et al. Myeloid sarcoma: clinico-pathologic, phenotypic and cytogenetic analysis of 92 adult patients. Leukemia. 2007;21:340–50.

    Article  CAS  PubMed  Google Scholar 

  146. Roby BB, Drehner D, Sidman JD. Granulocytic sarcoma of pediatric head and neck: an institutional experience. Int J Pediatr Otorhinolaryngol. 2013;77:1364–6.

    Article  PubMed  Google Scholar 

  147. Zhou J, Bell D, Medeiros LJ. Myeloid sarcoma of the head and neck region. Arch Pathol Lab Med. 2013;137:1560–8.

    Article  PubMed  Google Scholar 

  148. Badalian-Very G, Vergilio JA, Fleming M, et al. Pathogenesis of Langerhans cell histiocytosis. Annu Rev Pathol. 2013;8:1–20.

    Google Scholar 

  149. Behrens RJ, Levi AW, Westra WH, et al. Langerhans cell histiocytosis of the thyroid: a report of two cases and review of the literature. Thyroid. 2001;11:697–705.

    Article  CAS  PubMed  Google Scholar 

  150. Abbondanzo SL, Wenig BM. Non-Hodgkin’s lymphoma of the sinonasal tract. A clinicopathologic and immunophenotypic study of 120 cases. Cancer. 1995;75:1281–91.

    Article  CAS  PubMed  Google Scholar 

  151. Chan JK, Ng CS, Lo ST. Immunohistological characterization of malignant lymphomas of the Waldeyer’s ring other than the nasopharynx. Histopathology. 1987;11:885–99.

    Article  CAS  PubMed  Google Scholar 

  152. Cuadra-Garcia I, Proulx GM, Wu CL, et al. Sinonasal lymphoma: a clinicopathologic analysis of 58 cases from the Massachusetts General Hospital. Am J Surg Pathol. 1999;23:1356–69.

    Article  CAS  PubMed  Google Scholar 

  153. Fellbaum C, Hansmann ML, Lennert K. Malignant lymphomas of the nasal cavity and paranasal sinuses. Virchows Arch A Pathol Anat Histopathol. 1989;414:399–405.

    Article  CAS  PubMed  Google Scholar 

  154. Handlers JP, Howell RE, Abrams AM, et al. Extranodal oral lymphoma. Part I. A morphologic and immunoperoxidase study of 34 cases. Oral Surg Oral Med Oral Pathol. 1986;61:362–7.

    Article  CAS  PubMed  Google Scholar 

  155. Menarguez J, Mollejo M, Carrion R, et al. Waldeyer ring lymphomas. A clinicopathological study of 79 cases. Histopathology. 1994;24:13–22.

    Article  CAS  PubMed  Google Scholar 

  156. Morgan K, MacLennan KA, Narula A, et al. Non-Hodgkin’s lymphoma of the larynx (stage IE). Cancer. 1989;64:1123–7.

    Article  CAS  PubMed  Google Scholar 

  157. Shima N, Kobashi Y, Tsutsui K, et al. Extranodal non-Hodgkin’s lymphoma of the head and neck. A clinicopathologic study in the Kyoto-Nara area of Japan. Cancer. 1990;66:1190–7.

    Article  CAS  PubMed  Google Scholar 

  158. Swerdlow JB, Merl SA, Davey FR, et al. Non-Hodgkin’s lymphoma limited to the larynx. Cancer. 1984;53:2546–9.

    Article  CAS  PubMed  Google Scholar 

  159. van der Waal RI, Huijgens PC, van der Valk, et al. Characteristics of 40 primary extranodal non-Hodgkin lymphomas of the oral cavity in perspective of the new WHO classification and the International Prognostic Index. Int J Oral Maxillofac Surg. 2005;34:391–5.

    Article  PubMed  Google Scholar 

  160. Vega F, Lin P, Medeiros LJ. Extranodal lymphomas of the head and neck. Ann Diagn Pathol. 2005;9:340–50.

    Article  PubMed  Google Scholar 

  161. Frierson Jr HF, Innes Jr DJ, Mills SE, et al. Immunophenotypic analysis of sinonasal non-Hodgkin’s lymphomas. Hum Pathol. 1989;20:636–42.

    Article  PubMed  Google Scholar 

  162. Mills SE, Stelow EB, Hunt JL. Hematopoietic and lymphoid disorders; tumors of the upper aerodigestive tract and ear. In: AFIP atlas of tumor pathology, fourth series. Washington, DC: American Registry of Pathology; 2004.

    Google Scholar 

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Martinez, D., Colomo, L., Soldini, D., Campo, E. (2016). Benign and Malignant Lymphoid Lesions of the Head and Neck. In: Cardesa, A., Slootweg, P., Gale, N., Franchi, A. (eds) Pathology of the Head and Neck. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-49672-5_13

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