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Transition Metal-Catalyzed, Directing Group-Assisted C(sp3)–H Bond Functionalization

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Sustainable C(sp3)-H Bond Functionalization

Part of the book series: SpringerBriefs in Molecular Science ((GREENCHEMIST))

Abstract

Highly regioselective C(sp3)–H bond functionalization is a very important and attractive research topic as organic compounds usually contain several different kinds of C–H bonds (sp, sp2, and sp3). The introduction of a directing group has become one of the most efficient strategies to achieve this target. In this chapter, we discuss the latest advances in metal-catalyzed arylation, allenylation, amidation, and alkylation of inactivated C(sp3)–H bonds enabled by the directing group strategy.

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Acknowledgments

The National Natural Science Foundation of China (No. 21372114, 21172106), and the Research Fund for the Doctoral Program of Higher Education of China (20120091110010) and the Brand Major Project of Jiangsu Province are kindly acknowledged.

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Authors and Affiliations

  1. State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China

    Jin Xie & Chengjian Zhu

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  1. Jin Xie
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  2. Chengjian Zhu
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Correspondence to Chengjian Zhu .

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Xie, J., Zhu, C. (2016). Transition Metal-Catalyzed, Directing Group-Assisted C(sp3)–H Bond Functionalization. In: Sustainable C(sp3)-H Bond Functionalization. SpringerBriefs in Molecular Science(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-49496-7_1

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