Abstract
Inspired by the demand of green and sustainable chemistry, modern synthetic chemists have devoted to develop general and practical methods to construct complex molecules. Due to the sp hybridization of the triple bond and the connected halogen atom, haloalkynes, such as bromoalkynes, chloroalkynes and iodoalkynes, have shown both controllable electrophilic and nucleophilic properties, rendering them highly versatile and robust synthons. As the immense usefulness of haloalkynes, impressive efforts have been devoted to this area in the past decades and many novel chemical reactions have been developed. In this chapter, we will introduce the physical property of haloalkynes, classify the reaction intermediate types derived from haloalkynes, and also hope to give the readers a comprehensive understanding of haloalkyne chemistry.
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Jiang, H., Zhu, C., Wu, W. (2016). Introduction. In: Haloalkyne Chemistry. SpringerBriefs in Molecular Science(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-49001-3_1
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DOI: https://doi.org/10.1007/978-3-662-49001-3_1
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