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Multimodale und palliative Therapie des Lungenkarzinoms

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Thoraxchirurgie für den Allgemein- und Viszeralchirurgen
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Zusammenfassung

Unter einer multimodalen Therapie versteht man die Anwendung mehrerer Behandlungsverfahren wie medikamentöse Therapie, Strahlentherapie und operative Therapie. In diesem Kapitel werden verschiedene multimodale Konzepte dargestellt. In der palliativen Therapie werden Medikamente wie Chemotherapeutika oder Tyrosinkinase-Inhibitoren eingesetzt mit dem Ziel, die Lebenszeit zu verlängern und die Lebensqualität zu verbessern. Die palliative Strahlentherapie dient der Verbesserung der Lebensqualität durch Linderung oder Vermeidung von Symptomen.

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Literatur

  • Albain KS, Swann RS, Rusch VW, et al. (2009) Radiotherapy plus chemotherapy with or without surgical resection for stage III non-small-cell lung cancer: a phase III: randomised controlled trial. Lancet 374: 379–386

    Article  CAS  Google Scholar 

  • Anonymous (1995) Chemotherapy in non small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomized clinical trials. BMJ 311: 899–909

    Article  Google Scholar 

  • Arriagada R, Bergman B, Dunant A, et al. (2004) Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer. N Engl J Med 350: 351–360

    Article  Google Scholar 

  • Aupérin A, Le Péchoux C, Rolland E, et al. (2010) Meta-analysis of concomitant versus sequential radiochemotherapy in locally advanced non-small-cell lung cancer. J Clin Oncol. 28: 2181–2190

    Article  Google Scholar 

  • Bradley JD, Paulus R, Komaki R, et al. (2015) Standard-dose versus high-dose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage IIIA or IIIB non-small-cell lung cancer (RTOG 0617): a randomised, two-by-two factorial phase 3 study. Lancet Oncol 16: 187–199

    Article  CAS  Google Scholar 

  • De Ruysscher D, Pijls-Johannesma M, Vansteenkiste J, et al. (2006) Systematic review and meta-analysis of randomised, controlled trials of the timing of chest radiotherapy in patients with limited-stage, small-cell lung cancer. Ann Oncol 17: 543–552

    Article  CAS  Google Scholar 

  • Eberhardt WE, Albain KS, Pass H, et al. (2003) Induction treatment before surgery for non-small cell lung cancer. Lung Cancer 42: S9–14

    Article  Google Scholar 

  • Fairchild A, Harris K, Barnes E, et al. (2008) Palliative Thoracic Radiotherapy for Lung Cancer: A Systematic Review. J Clin Oncol 26: 4001–4011

    Article  Google Scholar 

  • Kubota K, Hida T, Ishikura S, et al. (2014) Etoposide and cisplatin versus irinotecan and cisplatin in patients with limited-stage small-cell lung cancer treated with etoposide and cisplatin plus concurrent accelerated hyperfractionated thoracic radiotherapy (JCOG0202): a randomised phase 3 study. Lancet Oncol 15: 106–113

    Article  CAS  Google Scholar 

  • Kunitoh H, Kato H, Tsubo M, et al. (2008) Phase II Trial of Preoperative Chemoradiotherapy Followed by Surgical Resection in Patients With Superior Sulcus Non–Small-Cell Lung Cancers: Report of Japan Clinical Oncology Group Trial 9806 J Clin Oncol 26: 644–649

    Article  CAS  Google Scholar 

  • Lally BE, Zelterman D, Colasanto JM, et al. (2006) Postoperative Radiotherapy for Stage II or III Non–Small-Cell Lung Cancer Using the Surveillance, Epidemiology, and End Results Database J Clin Oncol 24: 2998–3006

    Article  Google Scholar 

  • O'Rourke N, Roqué I Figuls M, Farré Bernadó N, et al. (2010) Concurrent chemoradiotherapy in non-small cell lung cancer. Cochrane Database Syst Rev 16: CD002140

    Google Scholar 

  • Pignon JP, Tribodet H, Scagliotti GV, et al. (2008) Lung adjuvant cisplatin evaluation: a pooled analysis by the LACE collaborative group. J Clin Oncol 26: 3552–3559

    Article  Google Scholar 

  • PORT Meta-analysis Trialists Group (2005) Postoperative radiotherapy for non-small cell lung cancer. Cochrane Database Syst Rev 2: CD002142

    Google Scholar 

  • Reck M, Heigener DF, Mok T, et al. (2013) Management of non-small-cell lung cancer: recent developments. Lancet 383: 709–719

    Article  Google Scholar 

  • Robinson CG, Patel AP, Bradley JD, et al. (2015) Postoperative Radiotherapy for Pathologic N2 Non–Small- Cell Lung Cancer Treated With Adjuvant Chemotherapy: A Review of the National Cancer Data Base. J Clin Oncol 33: 870–876

    Article  CAS  Google Scholar 

  • Robinson LA, Ruckdeschel JC, et al. (2007) Treatment of Non-small Cell Lung Cancer-Stage IIIA. ACCP Evidence-Based Clinical Practice Guidelines Chest 132: S 243–265

    Google Scholar 

  • Rosell R, Carcereny E, Gervais R, et al. (2012) Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial. Lancet Oncol 13: 239–246

    Article  CAS  Google Scholar 

  • Rusch VW, Giroux DJ, Kraut MJ, et al. (2007) Induction Chemoradiation and Surgical Resection for Superior Sulcus Non–Small-Cell Lung Carcinomas: Long- Term Results of Southwest Oncology Group Trial 9416 (Intergroup Trial 0160). J Clin Oncol 25: 313–318

    Article  Google Scholar 

  • Sandler A, Gray R, Perry MC, et al. (2007) Paclitaxel-carboplatin alone or with bevacizumab for non-small cell lung cancer. N Engl J Med 355: 2542–2550

    Article  Google Scholar 

  • Scagliotti GV, Parikh P, von Pawel J, et al. (2008) Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced stage non-small cell lung cancer. J Clin Oncol 26: 3543–3551

    Article  CAS  Google Scholar 

  • Schiller JH, Harrington D, Belani CP, et al. (2002) Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer. N Engl J Med 346: 92–98

    Article  CAS  Google Scholar 

  • Shaw AT, Kim DW, Nakagawa K, et al. (2013) Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med 368: 2385–2394

    Article  CAS  Google Scholar 

  • Slotman B, Faivre-Finn C, Kramer G, et al. (2007) Prophylactic Cranial Irradiation in Extensive Small-Cell Lung Cancer. N Engl J Med 357: 664–672

    Article  CAS  Google Scholar 

  • Slotman BJ, van Tinteren H, Praag JO, et al. (2015) Use of thoracic radiotherapy for extensive stage small-cell lung cancer: a phase 3 randomised controlled trial. Lancet 385: 36–42

    Article  Google Scholar 

  • Spiro SG, James LE, Rudd RM, et al. (2006) Early Compared With Late Radiotherapy in Combined Modality Treatment for Limited Disease Small-Cell Lung Cancer: A London Lung Cancer Group Multicenter Randomized Clinical Trial and Meta-Analysis. J Clin Oncol 24: 3823–3830

    Article  CAS  Google Scholar 

  • Strauss GM, Hemdon JE 2nd, Maddaus MA, et al. (2008) Adjuvant paclitaxel plus carboplatin compared with observation in stage IB non-small-cell lung cancer: CALGB 9633 with the Cancer and Leukemia Group B, Radiation Therapy Oncology Group, and North Central Cancer Treatment Group Study Groups. J Clin Oncol 26: 5043–5051

    Article  CAS  Google Scholar 

  • Sun JM, Ahn YC, E. K. Choi EK, et al. (2013) Phase III trial of concurrent thoracic radiotherapy with either first- or third-cycle chemotherapy for limited-disease small-cell lung cancer. Ann Oncol. 24: 2088–2092

    Article  Google Scholar 

  • Temel JS, Greer JA, Muzikansky A, et al. (2010) Early palliative care for patients with metastatic non-small-cell lung cancer. N Engl J Med 363: 733–742

    Article  CAS  Google Scholar 

  • Thomas M, Rübe C, Hoffknecht P, et al. (2008) Effect of preoperative chemoradiation in addition to preoperative chemotherapy: a randomised trial in stage III non-small-cell lung cancer. Lancet Oncol 9: 636–648

    Article  Google Scholar 

  • van Meerbeeck JP, Kramer GW, Van Schil PE (2007) Randomized controlled trial of resection versus radiotherapy after induction chemotherapy in stage IIIA-N2 non-small-cell lung cancer. J Natl Cancer Inst 99: 442–450

    Article  Google Scholar 

  • Vokes EE, Herndon II JE, Kelley MJ, et al. (2007) Induction Chemotherapy Followed by Chemoradiotherapy Compared With Chemoradiotherapy Alone for Regionally Advanced Unresectable Stage III Non–Small-Cell Lung Cancer: Cancer and Leukemia Group B. J Clin Oncol 25: 1698–1704

    Article  CAS  Google Scholar 

  • Winton TL, Livingston R, Johnson D, et al. (2005) Vinorelbine plus cisplatin versus observation in resected non-small cell lung cancer. N Engl J Med 352: 2589–2597

    Article  CAS  Google Scholar 

  • Zhang W, Jiang W, Luan L, et al. (2014) Prophylactic cranial irradiation for patients with small-cell lung cancer: a systematic review of the literature with meta-analysis. BMC Cancer 14: 793–799

    Article  Google Scholar 

  • Zheng X, Schipper M, Kidwell K, et al. (2014) Survival Outcome After Stereotactic Body Radiation Therapy and Surgery for Stage I Non-Small Cell Lung Cancer: A Meta-Analysis. Int J Radiat Oncol Biol Phys 90: 603–611

    Article  Google Scholar 

  • Zhou C, Wu YL, Chen G, et al. (2011) Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study. Lancet Oncol 12: 735–742

    Article  CAS  Google Scholar 

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Schmittel, A., Höcht, S. (2018). Multimodale und palliative Therapie des Lungenkarzinoms. In: Schneider, P., Kruschewski, M., Buhr, H. (eds) Thoraxchirurgie für den Allgemein- und Viszeralchirurgen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-48710-5_21

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  • DOI: https://doi.org/10.1007/978-3-662-48710-5_21

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