Zusammenfassung
Bis heute fehlen direkte Vergleiche zwischen pharmakologischer und nichtpharmakologischer Behandlung von Tic-Störungen inklusive Tourette-Syndrom. Eine pharmakologische Behandlung soll dann gewählt werden, wenn subjektive bzw. objektive Belastungen durch die Tics längerfristig ein von den Betroffenen nicht mehr akzeptables Maß an Beeinträchtigung erreichen. Dies können körperliche Schmerzen, Ausgrenzung mit psychosozialem Rückzug, schulische Schwierigkeiten usw. sein. Eine Medikation hat nach heutigem Wissensstand nur eine lindernde, d. h. die Tics reduzierende, aber keine heilende Wirkung. Ziel ist daher eine Reduktion der Tics auf ein erträgliches Maß, kein vollständiges Sistieren. Im folgenden Kapitel sind vor allem die Dopamin-Antagonisten mit guter Wirksamkeit auf Tics aufgeführt. Es werden aber auch Hinweise hinsichtlich der Berücksichtigung von komorbiden Störungen bei der Behandlungsplanung gegeben.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Literatur
Bloch MH, Landeros-Weisenberger A, Kelmendi B, Coric V, Bracken MB, Leckman JF (2006) A systematic review: antipsychotic augmentation with treatment refractory obsessive-compulsive disorder. Mol Psychiatry 11:622–632
Bloch MH, Panza KE, Landeros-Weisenberger A, Leckman JF (2009) Meta-analysis: treatment of attention-deficit /hyperactivity disorder in children with comorbid tic disorders. J Am Acad Child Adeolesc Psychiatry 48:884–893
Cath DC, Hedderly T, Ludolph AG, ESSTS Guidelines Group, - (2011) European clinical guidelines for Tourette syndrome and other tic disorders. Part I: assessment. Eur Child Adolesc Psychiatry 20:155–171
Cortese S, Holtmann M, Banaschewski T et al (2013) Practitioner review: current best practice in the management of adverse events during treatment with ADHD medications in children and adolescents. J Child Psychol Psyc 54:227–246 (on behalf of the European ADHD Guidelines Group)
Cummings DD, Singer HS, Krieger M, Miller TL, Mahone EM (2002) Neuropsychiatric effects of guanfacine in children with mild Tourette syndrome: a pilot study. Clin Neuropharmacol 25:325–332
Dilling H, Mombour W, Schmidt MH (Hrsg) (2013) Internationale Klassifikation psychischer Störungen. ICD-10 Kapitel V (F) Klinisch-diagnostische Leitlinien, 9. Aufl. Huber, Bern
Döpfner M, Roessner V, Woitecki K, Rothenberger A (2010) Tic-Störungen. Leitfaden Kinder- und Jugendpsychiatrie Bd. 13. Hogrefe, Göttingen
Eggers C, Rothenberger A, Berghaus U (1988) Clinical and neurobiological findings in children suffering from tic disease following treatment with tiapride. Eur Arch Psychiatry Neurol Sci 237:223–229
Falkai P, Wittchen H-U (Hrsg) (2015) American Psychiatric Association. Diagnostisches und Statistisches Manual Psychischer Störungen DSM-5®. Hogrefe, Göttingen
Freeman RD (2007) Tic disorders and ADHD: answers from a world-wide clinical dataset on Tourette syndrome. Eur Child Adolesc Psychiatry 16(Suppl 1):15–23
Gevensleben H, Kleemeyer M, Rothenberger LG et al (2013) Neurofeedback in ADHD: further pieces of the puzzle. Brain Topogr 27:20–32
Ghanizadeh A, Haghighi A (2014) Aripiprazole versus risperidone for treating children and adolescents with tic disorder: A randomized double blind clinical trial. Child Psychiatry Hum Dev 45:596–603
Ho CS, Chen HJ, Chiu NC, Shen EY, Lue HC (2009) Short-term sulpiride treatment of children and adolescents with Tourette syndrome or chronic tic disorder. J Formos Med Assoc 108:788–793
Howson AL, Batth S, Ilivitsky V, Boisjoli A, Jaworski M, Mahoney C, Knott VJ (2004) Clinical and attentional effects of acute nicotine treatment in Tourette‘s syndrome. Eur Psychiatry 1:102–112
Jankovic J, Kurlan R (2011a) Tourette syndrome evolving concepts. Mov Disord 26:1149–1156
Jankovic J, Kurlan R (2011b) Reply to: treatment of tics in patients with Tourette Syndrome: recommendations according to the European Society for the Study of Tourette Syndrome. Mov Disord 26:2448
Kurlan R (2003) Tourette‘s syndrome: are stimulants safe? Curr Neurol Neurosci Rep 3:285–288
Kurlan R, Johnson D, Kaplan EL (2008) Streptococcal infection and exacerbations of childhood tics and obsessive-compulsive symptoms: a prospective blinded cohort study. Pediatrics 121:1188–1197
Lieberman JA (2004) Dopamine partial agonists. A new class of antipsychotics. CNS Drugs 18:251–267
Mogwitz S, Buse J, Ehrlich S, Roessner V (2013) Clinical pharmacology of dopamine-‘modulating agents’ in Tourette’s syndrome. Int Rev Neurobiol 112:281–349
Müller-Vahl KR, Schneider U, Prevedel H, Theloe K, Kolbe H, Daldrup T, Emrich HM (2003) Delta 9-tetrahydrocannabinol (THC) is effective in the treatment of tics in Tourette syndrome: a 6-week randomized trial. J Clin Psychiatry 64:459–465
Müller-Vahl K, Münchau A, Poewe W, Roessner V, Rothenberger A, Vingerhoets F et al (2008) Ticstörungen. In: Diemer HC, Putzki N (Hrsg) Leitlinien für Diagnostik und Therapie in der Neurologie, 4. Aufl. Thieme, Stuttgart, S 125–129
Müller-Vahl KR, Cath DC, Cavanna AE, ESSTS Guidelines Group, - (2011a) European clinical guidelines for Tourette syndrome and other tic disorders. Part IV: deep brain stimulation. Eur Child Adolesc Psychiatry 20:209–217
Müller-Vahl KR, Roessner V (2011b) Treatment of tics in patients with Tourette Syndrome: recommendations according to the European Society for the Study of Tourette Syndrome. Mov Disord 26:2447 (on behalf of the European Society for the Study of Tourette Syndrome (ESSTS))
Palumbo D, Spencer T, Lynch J, Co-Chien H, Faraone SV (2004) Emergence of tics in children with ADHD: impact of once-daily OROS methylphenidate therapy. J Child Adolesc Psychopharmacol 14:185–194
Robertson MM, Stern JS (2000) Gilles de la Tourette syndrome: symptomatic treatment based on evidence. Eur Child Adolesc Psychiatry 9(Suppl 1):I60–I75
Roessner V, Rothenberger A (2013) Pharmacological treatment of tics. In: Martino D, Leckman JF (Hrsg) Tourette Syndrome. Oxford Press, New York
Roessner V, Banaschewski T, Rothenberger A (2004) Z Kinder Jug-Psych. Therapy of tic disorders 32:245–263
Roessner V, Becker A, Banaschewski T, Rothenberger A (2005) Tic disorders and obsessive compulsive disorder: where is the link? In: Brooks DJ, Fleischhacker WW (Hrsg) Neurodevelopmental disorders. Springer, Wien, S 69–99
Roessner V, Robatzek M, Knapp G, Banaschewski T, Rothenberger A (2006) First-onset tics in patients with attention-deficit-hyperactivity disorder: impact of stimulants. Dev Med Child Neurol 48:616–621
Roessner V, Plessen KJ, Rothenberger A, ESSTS Guidelines Group, - (2011a) European clinical guidelines for Tourette syndrome and other tic disorders. Part II: pharmacological treatment. Eur Child Adolesc Psychiatry 20:173–196
Roessner V, Rothenberger A, Rickards H, Hoekstra PJ (2011b) European clinical guidelines for Tourette syndrome and other tic disorders. Eur Child AdolescPsychiatry 20:153–154
Rothenberger A (1976) Zur Therapie kindlicher Verhaltensstörungen mit Sulpirid. Kinderarzt 5:561–563
Rothenberger A, Banaschewski T, Roessner V (2007) Tic-Störungen. In: DGKJPP, BAG, PKJPP (Hrsg) Leitlinien zur Diagnostik und Therapie von psychischen Störungen im Säuglings-, Kindes- und Jugendalter, 3. Aufl. Deutscher Ärzteverlag, Köln, S 319–325
Rothenberger A, Roessner V (2013) The phenomenology of attention-deficit/hyperactivity disorder in Tourette syndrome. In: Martino D, Leckman JF (Hrsg) Tourette-Syndrome. Oxford Press, New York, S 26–49
Sallee FR, Nesbitt L, Jackson C, Sine L, Sethuraman G (1997) Relative efficacy of haloperidol and pimozide in children and adolescents with Tourette‘s disorder. Am J Psychiatry 154:1057–1062
Sallee FR, Kurlan R, Goetz CG et al (2000) Ziprasidone treatment of children and adoelscents with Tourette’s syndrome: a pilot study. J Am Acad Child Psychiatry 39:292–299
Scahill L (2009) Alpha-2 adrenergic agonists in children with inattention, hyperactivity and impulsiveness. CNS Drugs 23:43–49
Scahill L, Riddle MA, King RA, Hardin MT, Rasmusson A, Makuch RW, Leckman JF (1997) Fluoxetine has no marked effect on tic symptoms in patients with Tourette‘s syndrome: a double-blind placebo-controlled study. J Child Adolesc Psychopharmacol 7:75–85
Scahill L, Leckman JF, Schultz RT, Katsovich L, Peterson BS (2003) A placebo-controlled trial of risperidone in Tourette syndrome. Neurology 60:1130–1135
Schmider J, Hoff P (1998) Clozapine in Tourette‘s syndrome. J Clin Psychopharmacol 18:88–89
Tourette Syndrome Study Group (2002) Treatment of ADHD in children with tics: a randomized controlled trial. Neurology 58:527–536
Verdellen C, van de Griendt J, Hartmann A, Murphy T, ESSTS Guidelines Group (2011) European clinical guidelines for Tourette syndrome and other tic disorders. Part III: behavioural and psychosocial interventions. Euro Child Adolesc Psychiatry 20:197–207
Weisman H, Qureshi A, Leckman JF, Scahill L, Bloch MH (2013) Systematic review: Pharmacological treatment of tic disorders efficacy of antipsychotic and alpha-2 adrenergic agonist agents. Neurosci Biobehav Rev 37:1162–1171
Yoo HK, Joung YS, Lee JS et al (2013) A multicenter, randomized, double-blind, placebo-controlled study of aripiprazole in children and adolescents with Tourette’s disorder. J Clin Psychiatry 74(8):e772–e780
Zheng Y, Zhang Z-J, Han X-M et al (2015) A proprietary herbal medicine (5-ling granule) for Tourette syndrome: a randomized controlled trial. J Child Psychol Psychiatry. Doi:10.1111/jcpp.12432
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Roessner, V., Rothenberger, A. (2016). Tic-Störungen. In: Gerlach, M., Mehler-Wex, C., Walitza, S., Warnke, A., Wewetzer, C. (eds) Neuro-/Psychopharmaka im Kindes- und Jugendalter. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-48624-5_26
Download citation
DOI: https://doi.org/10.1007/978-3-662-48624-5_26
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-48623-8
Online ISBN: 978-3-662-48624-5
eBook Packages: Medicine (German Language)