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Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung

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Neuro-/Psychopharmaka im Kindes- und Jugendalter

Zusammenfassung

In der spezifischen Behandlung der Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung (ADHS) findet die medikamentöse Therapie häufige Anwendung. Dabei stehen in erster Linie die Psychostimulanzien Methylphenidat und Amphetamin sowie Atomoxetin als Nicht-Psychostimulanz zur Verfügung. Langwirksame Formulierungen von Methylphenidat bieten häufig Vorteile in Wirkung und Compliance. In der Wahl des geeigneten Medikamentes sind, eingebettet in ein multimodales Behandlungskonzept, individuelle Gegebenheiten wie Komorbiditäten zu berücksichtigen. Unter der Behandlung sind regelmäßige Kontrollen z. B. der Gewichtsentwicklung zur Erfassung eventueller unerwünschter Arzneimittelwirkungen durchzuführen. Das folgende Kapitel gibt neben der Störungsdefinition einen Überblick über diagnostische Voraussetzungen, die individuelle Indikationsstellung und Anwendung der Psychopharmakotherapie der ADHS.

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Literatur

  • AACAP Official Action (American Association of Child and Adolescent Psychiatry) (2007) Practise parameter for the assessment and treatment of children and adolescents with attention-deficit/hyperactivity disorder. J Am Acad Child Psy 46:894–921

    Article  Google Scholar 

  • Abikoff H, McGough J, Vitiello B et al (2005) Sequential pharmacotherapy for children with comorbid attention-deficit/hyperactivity and anxiety disorders. J Am Acad Child Adolesc Psychiatry 44:418–427

    Article  PubMed  Google Scholar 

  • Aman MG, Binder C, Turgay A (2004) Risperidone effects in the presence/absence of psychostimulant medicine in children with ADHD, other disruptive behavior disorders, and subaverage IQ. J Child Adolesc Psychopharmacol 14:243–254

    Article  PubMed  Google Scholar 

  • Banaschewski T, Coghill D, Santosh P et al (2006) Long-acting medications for the hyperkinetic disorders. A systematic review and European treatment guideline. Eur Child Adolesc Psychiatry 15:476–495

    Article  PubMed  Google Scholar 

  • Buitelaar JK, Danckaerts M, Gillberg C et al (2004) A prospective, multicenter, open-label assessment of atomoxetine in non-North American children and adolescents with ADHD. Eur Child Adoles Psy 13:249–257 (Atomoxetine International Study Group)

    Google Scholar 

  • Bundesärztekammmer Vorstand (2007) Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung (ADHS) Stellungnahme auf Empfehlung des Wissenschaftlichen Beirats. Deutscher Ärzte Verlag, Köln

    Google Scholar 

  • Canadian Attention Deficit Hyperactivity Disorder Resource Alliance (CADDRA) (2011) Canadian ADHD practice guidelines, 3. Aufl. CADDRA, Toronto

    Google Scholar 

  • Cortese S, Holtmann M, Banaschewski T et al (2013) Practitioner review: current best practice in the management of adverse events during treatment with ADHD medications in children and adolescents. J Child Psychol Psyc 54:227–224

    Article  Google Scholar 

  • Cortese S, Ferrin M, Brandeis D et al (2015) Cognitive training for attention-deficit/hyperactivity disorder: meta-analysis of clinical and neuropsychological outcomes from randomized controlled trials. J Am Acad Child Adolesc Psychiatry 54:164–174

    Article  PubMed  PubMed Central  Google Scholar 

  • Dilling H, Mombour W, Schmidt MH (Hrsg) (2013) Internationale Klassifikation psychischer Störungen. ICD-10 Kapitel V (F) Klinisch-diagnostische Leitlinien, 9. Aufl. Huber, Bern

    Google Scholar 

  • Döpfner M, Lehmkuhl G, Schepker R, Frölich J (2007) Hyperkinetische Störungen. In: Deutsche Gesellschaft für Kinder- und Jugendpsychiatrie und Psychotherapie, Bundesarbeitsgemeinschaft Leitender Klinikärzte für Kinder- und Jugendpsychiatrie und Psychotherapie, Psychotherapie und Bundesverband der Ärzte für Kinder- und Jugendpsychiatrie und Psychotherapie (Hrsg) Leitlinien zu Diagnostik und Therapie von psychischen Störungen im Säuglings-, Kindes- und Jugendalter, 3. Aufl. Deutscher Ärzte-Verlag, Köln, S 239–254

    Google Scholar 

  • Falkai P, Wittchen H-U (Hrsg) (2015) American Psychiatric Association. Diagnostisches und Statistisches Manual Psychischer Störungen DSM-5. Hogrefe, Göttingen

    Google Scholar 

  • Faraone SV, Buitelaar J (2010) Comparing the efficacy of stimulants for ADHD in children and adolescents using meta-analysis. Eur Child Adoles Psy 19:353–364

    Article  Google Scholar 

  • Faraone SV, Biederman J, Spencer TJ, Aleardi M (2006) Comparing the efficacy of medications for ADHD using meta-analysis. Med Gen Med 8:4

    Google Scholar 

  • Findling RL, Newcorn JH, Malone RP, Waheed A, Prince JB, Kratochvil CJ (2007) Pharmacotherapy of aggression in a 9-year-old with ADHD. J Am Acad Child Adolesc Psychiatry 46:653–658

    Article  PubMed  Google Scholar 

  • Geller D, Donnelly C, Lopez F et al (2007) Atomoxetine treatment for pediatric patients with attention-deficit/hyperactivity disorder with comorbid anxiety disorder. J Am Acad Child Adolesc Psychiatry 46:1119–1127

    Article  PubMed  Google Scholar 

  • Greenhill L (2002) Stimulant medication treatment of children with attention deficit hyperactivity disorder. In: Jensen PS, Cooper JR (Hrsg) Attention deficit hyperactivity disorder: state of the science. Best practices. Civic Research Institute, Kingston (NJ)

    Google Scholar 

  • Handen BL, Feldman HM, Lurier A, Murray PJ (1999) Efficacy of methylphenidate among preschool children with developmental disabilities and ADHD. J Am Acad Child Adolesc Psychiatry 38:805–812

    Article  CAS  PubMed  Google Scholar 

  • Heal DJ, Smith SL, Gosden J, Nutt DJ (2013) Amphetamine, past and present – A pharmacological and clinical perspective. J Psychopharmacol 27:479–496

    Article  PubMed  PubMed Central  Google Scholar 

  • Jacob CP, Romanos J, Dempfle A et al (2007) Co-morbidity of adult attention-deficit/hyperactivity disorder with focus on personality traits and related disorders in a tertiary referral center. Eur Arch Psychiatry Clin Neurosci 257:309–317

    Article  PubMed  Google Scholar 

  • Jans T, Kreiker S, Warnke A (2008) Multimodale Therapie der Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung im Kindesalter. Nervenarzt 79:791–800

    Article  CAS  PubMed  Google Scholar 

  • Jensen PS, Hinshaw SP, Kraemer HC et al (2001) ADHD comorbidity findings from the MTA study: comparing comorbid subgroups. J Am Acad Child Adolesc Psychiatry 40:147–158

    Article  CAS  PubMed  Google Scholar 

  • Kratochvil CJ, Vitiello B, Brent D, Bostic JQ, Naylor MW (2006) Selecting an antidepressant for the treatment of pediatric depression. J Am Acad Child Adolesc Psychiatry 45:371–373

    Article  PubMed  Google Scholar 

  • Loy JH, Merry SN, Hetrick SE, Stasiak K (2012) Atypical antipsychotics for disruptive behaviour disorders in children and youths. Cochrane Data Syst Rev 9:CD00855

    Google Scholar 

  • Markowitz JS, Patrick KS (2001) Pharmacokinetic and pharmacodynamic drug Interactions in the treatment of attention-deficit hyperactivity disorder. Clin Pharmacokinet 40:753–771

    Article  CAS  PubMed  Google Scholar 

  • Kelsey DK, Sumner CR, Casat CD et al (2004) Once-daily atomoxetine treatment for children with attention-deficit/hyperactivity disorder, including an assessment of evening and morning behavior: a double-blind, placebo-controlled trial. Pediatrics 114:e1–e8

    Article  PubMed  Google Scholar 

  • Michelson D, Allen AJ, Busner J et al (2002) Once-daily atomoxetine treatment for children and adolescents with attention deficit hyperactivity disorder: a randomized, placebo-controlled study. Am J Psychiatr 159:1896–1901

    Article  PubMed  Google Scholar 

  • MTA Cooperation Group (1999a) Multimodal treatment Study of Children with ADHD. A 14 month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder. Arch Gen Psychiatry 56:1073–1086

    Article  Google Scholar 

  • MTA Cooperation Group (1999b) Multimodal treatment Study of Children with ADHD. Moderators and Mediators of treatment response for children with attention-deficit/hyperactivity disorder. Arch Gen Psychiatry 56:1088–1096

    Article  Google Scholar 

  • MTA Cooperation Group (2004) National Institute of Mental Health Multimodal Treatment Study of ADHD follow-up: 24-month outcomes of treatment strategies for attention-deficit/hyperactivity disorder. Pediatrics 113:754–761

    Article  Google Scholar 

  • NICE (National Institute for Health and Clinical Excellence) (2008) Attention deficit hyperactivity disorder – diagnosis and management of ADHD in children, young people and adults. National clinical practice guideline number 72. The British Psychological Society and The Royal College of Psychiatrists, London

    Google Scholar 

  • Pearson DA, Santos CW, Roache JD et al (2003) Treatment effects of methylphenidate on behavioral adjustment in children with mental retardation and ADHD. J Am Acad Child Adolesc Psychiatry 42:209–216

    Article  PubMed  Google Scholar 

  • Pennick M (2010) Absorption of lisdexamfetamine dimesylate and its enzymatic conversion to d-amphetamine. Neuropsych Dis Treat 6:317–327

    Article  CAS  Google Scholar 

  • Pliszka SR, Crismon ML, Hughes CW et al (2006) Texas Consensus Conference Panel on Pharmacotherapy of Childhood Attention Deficit Hyperactivity Disorder. The Texas Children’s Medication Algorithm Project: revision of the algorithm for pharmacotherapy of attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 45:642–657

    Article  PubMed  Google Scholar 

  • Santosh PJ, Taylor E (2000) Stimulant drugs. Eur Child Adolesc Psychiatry 9(Suppl 1):I27–143

    Article  PubMed  Google Scholar 

  • Seixas M, Weiss M, Muller U (2012) Systematic review of national and international guidelines on attention-deficit hyperactivity disorder. J Psychopharmacol 26:753–765

    Article  PubMed  Google Scholar 

  • Simonoff E, Taylor E, Baird G et al (2013) Randomized controlled double-blind trial of optimal dose methylphenidate in children and adolescents with severe attention deficit hyperactivity disorder and intellectual disability. J Child Psychol Psyc 54:527–535

    Article  Google Scholar 

  • Sinzig J, Döpfner M, Lehmkuhl G, German Methylphenidate Study Group (2007) Long-acting methylphenidate has an effect on aggressive behavior in children with attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol 4:421–432

    Article  Google Scholar 

  • Sonuga-Barke EJS, Brandeis D, Cortese S, European ADHD Guidelines Group, - (2013) Nonpharmacological interventions for ADHD: systematic review and meta-analyses of randomized controlled trials of dietary and psychological treatments. Am J Psychiat 170:275–289

    Article  PubMed  Google Scholar 

  • Spencer T, Heiligenstein JH, Biederman J, Faries DE, Kratochvil Ch, Conners CK, Potter WZ (2002) Results from 2 proof-of-concept, placebo-controlled studies of in children with attention-deficit/hyperactivity disorder. J Clin Psychiat 63:1140–1147

    Article  CAS  Google Scholar 

  • Spencer TJ, Abikoff HB, Connor DF et al (2006) Efficacy and safety of mixed amphetamine salts extended release (adderall XR) in the management of oppositional defiant disorder with or without comorbid attention-deficit/hyperactivity disorder in school-aged children and adolescents: A 4-week, multicenter, randomized, double-blind, parallel-group, placebo-controlled, forced-dose-escalation study. Clin Ther 28:402–418

    Article  CAS  PubMed  Google Scholar 

  • Taurines R, Schmitt J, Renner T, Conner AC, Warnke A, Romanos M (2010) Developmental comorbidity in attention-deficit/hyperactivity disorder. ADHD Attent Def Hyp Disord 2:276–289

    Google Scholar 

  • Taylor E, Döpfner M, Sergeant J et al (2004) European clinical guidelines for hyperkinetic disorder-first upgrade. Eur Child Adolesc Psychiatry 1(Suppl 1):17–30 (13)

    Google Scholar 

  • Tucha O, Prell S, Mecklinger L et al (2006) Effects of methylphenidate on multiple components of attention in children with attention deficit hyperactivity disorder. Psychopharmacology 185:315–326

    Article  CAS  PubMed  Google Scholar 

  • Van der Oord S, Prins PJ, Oosterlaan J, Emmelkamp PM (2008) Efficacy of methylphenidate, psychosocial treatments and their combination in school-aged children with ADHD: a meta-analysis. Clin Psychol Rev 28:783–800

    Article  PubMed  Google Scholar 

  • Warnke A, Walitza S (2004) Methylphenidat in der Behandlung der Aufmerksamkeits-Defizit-Hyperaktivitätsstörung. In: Schulte-Markwort M, Warnke A (Hrsg) Methylphenidat. Thieme, Stuttgart, S 14–33

    Google Scholar 

  • Weisman H, Qureshi IA, Leckman JF, Scahill L, Bloch MH (2013) Systematic review: pharmacological treatment of tic disorders – efficacy of antipsychotic and alpha-2 adrenergic agonist agents. Neurosci Biobehav R 37:1162–1171

    Article  CAS  Google Scholar 

  • Werling A, Drechsler R, Walitza S (2014) Klinische Praxis der Aufmerksamkeitsdefizit-/Hyperaktivitätsstörungen und hyperkinetischen Störungen. Psych up2date 8:257–272

    Article  Google Scholar 

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Authors and Affiliations

  1. Zentrum für Kinder- und Jugendpsychiatrie, Universität Zürich, Neumünsterallee 9, 8032, Zürich, Schweiz

    Prof. Dr. med. Susanne Walitza

  2. Klinik für Psychiatrie und Psychotherapie im Kindes- und Jugendalter, Universitätsklinikum Tübingen, Osianderstraße 14-16, 72076, Tübingen, Deutschland

    Prof. Dr. med. Tobias Renner

  3. Klinik und Poliklinik für Kinder- u. Jugendpsychiatrie, Psychosomatik u. Psychotherapie, Universitätsklinikum Würzburg, Zentrum für Psychische Gesundheit, Füchsleinstraße 15, 97080, Würzburg, Deutschland

    Prof. Dr. med. Marcel Romanos

Authors
  1. Prof. Dr. med. Susanne Walitza
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  2. Prof. Dr. med. Tobias Renner
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  3. Prof. Dr. med. Marcel Romanos
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Correspondence to Susanne Walitza .

Editor information

Editors and Affiliations

  1. Zentrum für Seelische Gesundheit, Universitätsklinikum Würzburg, Würzburg, Germany

    Manfred Gerlach

  2. Privatklinik für Seelische Gesundheit, J, HEMERA Klinik, Bad Kissingen, Germany

    Claudia Mehler-Wex

  3. Zentrum für Kinder- und Jugendpsychiatri, Universität Zürich, Zürich, Zürich, Switzerland

    Susanne Walitza

  4. Zentrum für Seelische Gesundheit, Universitätsklinikum Würzburg, Würzburg, Bayern, Germany

    Andreas Warnke

  5. Abteilung Kinder Jugendpsychiatrie, Kliniken der Stadt Köln gGmbH, Köln, Germany

    Christoph Wewetzer

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Walitza, S., Renner, T., Romanos, M. (2016). Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung. In: Gerlach, M., Mehler-Wex, C., Walitza, S., Warnke, A., Wewetzer, C. (eds) Neuro-/Psychopharmaka im Kindes- und Jugendalter. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-48624-5_12

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  • DOI: https://doi.org/10.1007/978-3-662-48624-5_12

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