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Engineering Upconversion Nanoparticles for Multimodal Biomedical Imaging-Guided Therapeutic Applications

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Advances in Nanotheranostics I

Part of the book series: Springer Series in Biomaterials Science and Engineering ((SSBSE,volume 6))

Abstract

As one of the most important branches of nanotechnology, nanotheranostic medicine that aims at integrating diagnostic/therapeutic functions in one system is expected to provide novel strategies for accurate imaging-guided therapy of human major diseases like cancer. Among various inorganic or organic theranostic probes, lanthanide-doped upconversion nanoparticles (UCNPs) demonstrate superior advantages in upconversion luminescent imaging by contrast with traditional luminescent probes as well as great potential in the development as multimodal imaging (e.g., magnetic resonance imaging, computed tomography imaging, etc.) probes by the selective doping of various functional ions (e.g., Gd3+, Yb3+, Ho3+, etc.). Furthermore, by suitable surface engineering (e.g., mesoporous silica coating, biological molecule conjugation etc.), UCNPs can simultaneously serve as delivery vehicles of drugs/photosensitizers for multimodal therapeutic applications (e.g., chemotherapy, photodynamic therapy, etc.) under the above significant multimodal imaging guidance. Herein, we summarize and discuss the very recent progresses in the engineering of UCNPs for multimodal imaging-guided therapeutic applications.

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Authors and Affiliations

  1. State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-xi Road, Shanghai, 200050, People’s Republic of China

    Wenpei Fan, Jianlin Shi & Wenbo Bu

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  1. Wenpei Fan
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  2. Jianlin Shi
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Correspondence to Wenbo Bu .

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  1. Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, China

    Zhifei Dai

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Fan, W., Shi, J., Bu, W. (2016). Engineering Upconversion Nanoparticles for Multimodal Biomedical Imaging-Guided Therapeutic Applications. In: Dai, Z. (eds) Advances in Nanotheranostics I. Springer Series in Biomaterials Science and Engineering, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-48544-6_5

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