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Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement pp 93–110Cite as

Penetration Enhancer-Containing Vesicles for Cutaneous Drug Delivery

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Abstract

The function of vesicles as topical delivery systems is controversial with variable effects being reported in relation to the type of vesicles and their composition. A wide variety of lipids and surfactants can be used to prepare vesicles, and vesicle composition and preparation method influence their physicochemical properties (size, charge, lamellarity, thermodynamic state, deformability) and, therefore, their efficacy as drug delivery systems. In this chapter, composition, preparation, and results obtained by using penetration enhancer-containing vesicles, liposomes prepared by associating different penetration enhancers to phospholipids, are described. These systems have shown to improve cutaneous drug delivery, thanks to a combination of properties of vesicle carriers and penetration enhancers.

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Abbreviations

CLSM:

Confocal laser scanning microscopy

D:

Dialyzed

DCF:

Diclofenac

DCFNa :

Diclofenac sodium salt

DDS:

Drug delivery systems

E%:

Entrapment efficiency

FTIR:

Fourier transform infrared spectroscopy

HLB:

Hydrophile-lipophile balance

Lab:

Labrasol® (caprylocaproyl macrogol-8 glyceride, Gattefossé, France)

MLVs:

Multilamellar vesicles

ND:

Non-dialyzed

OA:

Oleic acid

Or:

Decylpolyglucoside (Oramix™ NS10, Seppic, France)

P50:

Phospholipon 50 (Lipoid GmbH, Germany)

P90G:

Phospholipon 90G (Lipoid GmbH, Germany)

P90H:

Phospholipon 90H (Lipoid GmbH, Germany)

PBS:

Phosphate-buffered saline

PC:

Phosphatidylcholine

PDI:

Polydispersity index

PE:

Penetration enhancer

PEG 400:

Polyethylene glycol 400

PEV-1:

Vesicles with Labrasol®

PEV-2:

Vesicles with Transcutol®

PEV-3:

Vesicles with cineole

PEVs:

Penetration enhancer-containing vesicles

PG:

Propylene glycol

SC:

Stratum corneum

SEM:

Scanning electron microscopy

SUV:

Small unilamellar vesicles

Tc:

Transition temperature

TEM:

Transmission electron microscopy

TRA:

Trans retinoic acid

Trc:

Transcutol® (diethylene glycol monoethyl ether, Gattefossé, France)

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Authors and Affiliations

  1. Department of Life and Environment Sciences, Section of Drug Sciences, University of Cagliari, Via Ospedale 72, Cagliari, 09124, Italy

    Maria Manconi, Chiara Sinico & Anna Maria Fadda

Authors
  1. Maria Manconi
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  2. Chiara Sinico
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  3. Anna Maria Fadda
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Corresponding author

Correspondence to Anna Maria Fadda .

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Editors and Affiliations

  1. Department of Manufacturing, Apoteka "Beograd", Belgrade, Serbia

    Nina Dragicevic

  2. San Francisco, California, USA

    Howard I. Maibach

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Manconi, M., Sinico, C., Fadda, A.M. (2016). Penetration Enhancer-Containing Vesicles for Cutaneous Drug Delivery. In: Dragicevic, N., Maibach, H. (eds) Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-47862-2_6

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  • DOI: https://doi.org/10.1007/978-3-662-47862-2_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-47861-5

  • Online ISBN: 978-3-662-47862-2

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