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Prospective

  • Qing-Ping ZengEmail author
Chapter
Part of the SpringerBriefs in Molecular Science book series (BRIEFSMOLECULAR)

Abstract

The exact mechanisms behind aging-related diseases remain unknown. Oxidative/nitrosative stress-mediated posttranslational modifications leading to protein misfolding and structural/functional abnormality have been supposed to be the plausible pathogenic initiators of neurodegenerative diseases. Obesity might be an outcome of the activation of iNOS and inactivation of eNOS, leading to mitochondrial loss and adipose whitening without adipose burning. Inflammation-driven mitochondrial dysfunction might be the intrinsic effector of Warburg effects showing potent ROS burst, which should enhance mutagenesis and tumorigenesis/carcinogenesis.

Keywords

Aging-related disease Cancer Obesity Warburg effect 

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© The Author(s) 2015

Authors and Affiliations

  1. 1.Tropical Medicine InstituteGuangzhou University of Chinese MedicineGuangzhouChina

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