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ART for Anti-inflammation

  • Qing-Ping ZengEmail author
Chapter
Part of the SpringerBriefs in Molecular Science book series (BRIEFSMOLECULAR)

Abstract

Chronic/acute synovitis, an early phase of RA, can be experimentally induced in mice by autoantigen/bacterial antigen challenging and live bacterial feeding. While a donor of NO replicates the modeling of synovitis, an inhibitor of NOS blocks the progression of synovitis, suggesting inflammation-triggered NO burst represents an etiological cause of synovitis. ART, via inhibiting iNOS, can ameliorate the synovial inflammation by mitigating NO-driven hypoxia, angiogenesis, and hyperplasia.

Keywords

ART Antigen Bacteria NO Synovitis 

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Copyright information

© The Author(s) 2015

Authors and Affiliations

  1. 1.Tropical Medicine InstituteGuangzhou University of Chinese MedicineGuangzhouChina

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