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NO and ART

  • Qing-Ping ZengEmail author
Chapter
Part of the SpringerBriefs in Molecular Science book series (BRIEFSMOLECULAR)

Abstract

NO, mainly synthesized by NOS, is a signal transducer that conveys internal and external stimulations. The isoform of eNOS/nNOS is responsible for stable NO production, while the isoform of iNOS can be induced by proinflammatory cytokines for NO burst. Bacteria also synthesize NO by their own bNOS. ART exerts distinct roles in a dose-dependent manner. Low-dose ART induces and activates eNOS/nNOS, whereas high-dose ART inactivates all isoforms of NOS. ART can also mimic NO to upregulate COX for evoking mitochondrial uncoupling and biogenesis.

Keywords

ART Dose-dependent effects COX NO NOS 

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© The Author(s) 2015

Authors and Affiliations

  1. 1.Tropical Medicine InstituteGuangzhou University of Chinese MedicineGuangzhouChina

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