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Epidemiology and Outcomes of Cutaneous Squamous Cell Carcinoma

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High-Risk Cutaneous Squamous Cell Carcinoma

Abstract

Non melanoma skin cancers (NMSCs), which consist of basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) are the most commonly diagnosed cancers in the United States. SCC accounts for only 20 % of all NMSCs however, it causes the majority of metastases and deaths from NMSC. Due to its commonness and overall excellent prognosis, SCC is excluded from national cancer registries in the United States. Hence; population-based incidence and outcome studies are lacking. In this chapter, current epidemiologic data on SCC incidence, risk factors for SCC formation (such as exposure to ultraviolet radiation, ionizing radiation, and infection with human papillomavirus) and overall prognosis of SCC will be discussed.

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References

  1. Johnson TM, Rowe DE, Nelson BR, Swanson NA. Squamous cell carcinoma of the skin (excluding lip and oral mucosa). J Am Acad Dermatol. 1992;26(3 Pt 2):467–84.

    Article  CAS  PubMed  Google Scholar 

  2. Schmults CD, Karia PS, Carter JB, Han J, Qureshi AA. Factors predictive of recurrence and death from cutaneous squamous cell carcinoma: a 10-year, single-institution cohort study. JAMA Dermatol. 2013;149(5):541–7.

    Article  PubMed  Google Scholar 

  3. Brantsch KD, Meisner C, Schonfisch B, Trilling B, Wehner-Caroli J, Rocken M, et al. Analysis of risk factors determining prognosis of cutaneous squamous-cell carcinoma: a prospective study. Lancet Oncol. 2008;9(8):713–20.

    Article  PubMed  Google Scholar 

  4. Miller DL, Weinstock MA. Nonmelanoma skin cancer in the United States: incidence. J Am Acad Dermatol. 1994;30(5 Pt 1):774–8.

    Article  CAS  PubMed  Google Scholar 

  5. Scotto J, Fraumeni J. Incidence of non melanoma skin cancer in the United States. Bethesda, MD: National Institutes of Health; 1983.

    Google Scholar 

  6. Scotto J, Kopf AW, Urbach F. Non-melanoma skin cancer among Caucasians in four areas of the United States. Cancer. 1974;34(4):1333–8.

    Article  CAS  PubMed  Google Scholar 

  7. Glass AG, Hoover RN. The emerging epidemic of melanoma and squamous cell skin cancer. JAMA. 1989;262(15):2097–100.

    Article  CAS  PubMed  Google Scholar 

  8. Karia PS, Han J, Schmults CD. Cutaneous squamous cell carcinoma: estimated incidence of disease, nodal metastasis, and deaths from disease in the United States, 2012. J Am Acad Dermatol. 2013;68(6):957–66.

    Article  PubMed  Google Scholar 

  9. Staples MP, Elwood M, Burton RC, Williams JL, Marks R, Giles GG. Non-melanoma skin cancer in Australia: the 2002 national survey and trends since 1985. Med J Aust. 2006;184(1):6–10.

    PubMed  Google Scholar 

  10. Green A, Battistutta D, Hart V, Leslie D, Weedon D. Skin cancer in a subtropical Australian population: incidence and lack of association with occupation. The Nambour Study Group. Am J Epidemiol. 1996;144(11):1034–40.

    Article  CAS  PubMed  Google Scholar 

  11. Buettner PG, Raasch BA. Incidence rates of skin cancer in Townsville, Australia. Int J Cancer. 1998;78(5):587–93.

    Article  CAS  PubMed  Google Scholar 

  12. McLean DI, Phillips N, Zhou Y, Gallagher R, Lee TK. 40-year trends in skin cancer in British Columbia, Canada, 1973 to 2003. J Cutan Med Surg. 2012;16(2):83–91.

    PubMed  Google Scholar 

  13. Jung GW, Metelitsa AI, Dover DC, Salopek TG. Trends in incidence of nonmelanoma skin cancers in Alberta, Canada, 1988–2007. Br J Dermatol. 2010;163(1):146–54.

    CAS  PubMed  Google Scholar 

  14. Magnus K. The Nordic profile of skin cancer incidence. A comparative epidemiological study of the three main types of skin cancer. Int J Cancer. 1991;47(1):12–9.

    Article  CAS  PubMed  Google Scholar 

  15. Hannuksela-Svahn A, Pukkala E, Karvonen J. Basal cell skin carcinoma and other nonmelanoma skin cancers in Finland from 1956 through 1995. Arch Dermatol. 1999;135(7):781–6.

    Article  CAS  PubMed  Google Scholar 

  16. Katalinic A, Kunze U, Schafer T. Epidemiology of cutaneous melanoma and non-melanoma skin cancer in Schleswig-Holstein, Germany: incidence, clinical subtypes, tumour stages and localization (epidemiology of skin cancer). Br J Dermatol. 2003;149(6):1200–6.

    Article  CAS  PubMed  Google Scholar 

  17. Iversen T, Tretli S. Trends for invasive squamous cell neoplasia of the skin in Norway. Br J Cancer. 1999;81(3):528–31.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Andersson EM, Paoli J, Wastensson G. Incidence of cutaneous squamous cell carcinoma in coastal and inland areas of Western Sweden. Cancer Epidemiol. 2011;35(6):e69–74.

    Article  CAS  PubMed  Google Scholar 

  19. Levi F, La Vecchia C, Te VC, Mezzanotte G. Descriptive epidemiology of skin cancer in the Swiss Canton of Vaud. Int J Cancer. 1988;42(6):811–6.

    Article  CAS  PubMed  Google Scholar 

  20. Roberts DL. Incidence of non-melanoma skin cancer in West Glamorgan, South Wales. Br J Dermatol. 1990;122(3):399–403.

    Article  CAS  PubMed  Google Scholar 

  21. Holme SA, Malinovszky K, Roberts DL. Changing trends in non-melanoma skin cancer in South Wales, 1988–98. Br J Dermatol. 2000;143(6):1224–9.

    Article  CAS  PubMed  Google Scholar 

  22. Brewster DH, Bhatti LA, Inglis JH, Nairn ER, Doherty VR. Recent trends in incidence of nonmelanoma skin cancers in the East of Scotland, 1992–2003. Br J Dermatol. 2007;156(6):1295–300.

    Article  CAS  PubMed  Google Scholar 

  23. Chuang TY, Popescu NA, Su WP, Chute CG. Squamous cell carcinoma. A population-based incidence study in Rochester, Minn. Arch Dermatol. 1990;126(2):185–8.

    Article  CAS  PubMed  Google Scholar 

  24. Gray DT, Suman VJ, Su WP, Clay RP, Harmsen WS, Roenigk RK. Trends in the population-based incidence of squamous cell carcinoma of the skin first diagnosed between 1984 and 1992. Arch Dermatol. 1997;133(6):735–40.

    Article  CAS  PubMed  Google Scholar 

  25. Serrano H, Scotto J, Shornick G, Fears TR, Greenberg ER. Incidence of nonmelanoma skin cancer in New Hampshire and Vermont. J Am Acad Dermatol. 1991;24(4):574–9.

    Article  CAS  PubMed  Google Scholar 

  26. Karagas MR, Greenberg ER, Spencer SK, Stukel TA, Mott LA. Increase in incidence rates of basal cell and squamous cell skin cancer in New Hampshire, USA. New Hampshire Skin Cancer Study Group. Int J Cancer. 1999;81(4):555–9.

    Article  CAS  PubMed  Google Scholar 

  27. Athas WF, Hunt WC, Key CR. Changes in nonmelanoma skin cancer incidence between 1977–1978 and 1998–1999 in Northcentral New Mexico. Cancer Epidemiol Biomarkers Prev. 2003;12(10):1105–8.

    PubMed  Google Scholar 

  28. Christenson LJ, Borrowman TA, Vachon CM, Tollefson MM, Otley CC, Weaver AL, et al. Incidence of basal cell and squamous cell carcinomas in a population younger than 40 years. JAMA. 2005;294(6):681–90.

    Article  CAS  PubMed  Google Scholar 

  29. Harris RB, Griffith K, Moon TE. Trends in the incidence of nonmelanoma skin cancers in southeastern Arizona, 1985–1996. J Am Acad Dermatol. 2001;45(4):528–36.

    Article  CAS  PubMed  Google Scholar 

  30. Gloster Jr HM, Neal K. Skin cancer in skin of color. J Am Acad Dermatol. 2006;55(5):741–60. quiz 61–4.

    Article  PubMed  Google Scholar 

  31. Singh B, Bhaya M, Shaha A, Har-El G, Lucente FE. Presentation, course, and outcome of head and neck skin cancer in African Americans: a case-control study. Laryngoscope. 1998;108(8 Pt 1):1159–63.

    Article  CAS  PubMed  Google Scholar 

  32. Rundel RD. Promotional effects of ultraviolet radiation on human basal and squamous cell carcinoma. Photochem Photobiol. 1983;38(5):569–75.

    Article  CAS  PubMed  Google Scholar 

  33. Alam M, Ratner D. Cutaneous squamous-cell carcinoma. N Engl J Med. 2001;344(13):975–83.

    Article  CAS  PubMed  Google Scholar 

  34. Soehnge H, Ouhtit A, Ananthaswamy ON. Mechanisms of induction of skin cancer by UV radiation. Front Biosci. 1997;2:d538–51.

    CAS  PubMed  Google Scholar 

  35. Grossman D, Leffell DJ. The molecular basis of nonmelanoma skin cancer: new understanding. Arch Dermatol. 1997;133(10):1263–70.

    Article  CAS  PubMed  Google Scholar 

  36. Brash DE, Rudolph JA, Simon JA, Lin A, McKenna GJ, Baden HP, et al. A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Proc Natl Acad Sci U S A. 1991;88(22):10124–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Tsai KY, Tsao H. The genetics of skin cancer. Am J Med Genet C Semin Med Genet. 2004;131C(1):82–92.

    Article  PubMed  Google Scholar 

  38. de Gruijl FR, van Kranen HJ, Mullenders LH. UV-induced DNA damage, repair, mutations and oncogenic pathways in skin cancer. J Photochem Photobiol B. 2001;63(1–3):19–27.

    Article  PubMed  Google Scholar 

  39. Schmitt J, Seidler A, Diepgen TL, Bauer A. Occupational ultraviolet light exposure increases the risk for the development of cutaneous squamous cell carcinoma: a systematic review and meta-analysis. Br J Dermatol. 2011;164(2):291–307.

    Article  CAS  PubMed  Google Scholar 

  40. Vitasa BC, Taylor HR, Strickland PT, Rosenthal FS, West S, Abbey H, et al. Association of nonmelanoma skin cancer and actinic keratosis with cumulative solar ultraviolet exposure in Maryland watermen. Cancer. 1990;65(12):2811–7.

    Article  CAS  PubMed  Google Scholar 

  41. International Agency for Research on Cancer Working Group on artificial ultraviolet (UV) light and skin cancer. The association of use of sunbeds with cutaneous malignant melanoma and other skin cancers: a systematic review. Int J Cancer. 2007;120(5):1116–22.

    Google Scholar 

  42. El Ghissassi F, Baan R, Straif K, Grosse Y, Secretan B, Bouvard V, et al. A review of human carcinogens--part D: radiation. Lancet Oncol. 2009;10(8):751–2.

    Article  PubMed  Google Scholar 

  43. Wehner MR, Shive ML, Chren MM, Han J, Qureshi AA, Linos E. Indoor tanning and non-melanoma skin cancer: systematic review and meta-analysis. BMJ. 2012;345:e5909.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Zhang M, Qureshi AA, Geller AC, Frazier L, Hunter DJ, Han J. Use of tanning beds and incidence of skin cancer. J Clin Oncol. 2012;30(14):1588–93.

    Article  PubMed  PubMed Central  Google Scholar 

  45. Giles GG, Marks R, Foley P. Incidence of non-melanocytic skin cancer treated in Australia. Br Med J. 1988;296(6614):13–7.

    Article  CAS  Google Scholar 

  46. Stern RS, Study PF-U. The risk of squamous cell and basal cell cancer associated with psoralen and ultraviolet A therapy: a 30-year prospective study. J Am Acad Dermatol. 2012;66(4):553–62.

    Article  CAS  PubMed  Google Scholar 

  47. Forman AB, Roenigk Jr HH, Caro WA, Magid ML. Long-term follow-up of skin cancer in the PUVA-48 cooperative study. Arch Dermatol. 1989;125(4):515–9.

    Article  CAS  PubMed  Google Scholar 

  48. Green A, Battistutta D. Incidence and determinants of skin cancer in a high-risk Australian population. Int J Cancer. 1990;46(3):356–61.

    Article  CAS  PubMed  Google Scholar 

  49. English DR, Armstrong BK, Kricker A, Winter MG, Heenan PJ, Randell PL. Demographic characteristics, pigmentary and cutaneous risk factors for squamous cell carcinoma of the skin: a case-control study. Int J Cancer. 1998;76(5):628–34.

    Article  CAS  PubMed  Google Scholar 

  50. English DR, Armstrong BK, Kricker A, Winter MG, Heenan PJ, Randell PL. Case-control study of sun exposure and squamous cell carcinoma of the skin. Int J Cancer. 1998;77(3):347–53.

    Article  CAS  PubMed  Google Scholar 

  51. Iannacone MR, Wang W, Stockwell HG, O’Rourke K, Giuliano AR, Sondak VK, et al. Patterns and timing of sunlight exposure and risk of basal cell and squamous cell carcinomas of the skin--a case-control study. BMC Cancer. 2012;12:417.

    Article  PubMed  PubMed Central  Google Scholar 

  52. Wu S, Han J, Laden F, Qureshi AA. Long-term ultraviolet flux, other potential risk factors, and skin cancer risk: a Cohort study. Cancer Epidemiol Biomarkers Prev. 2014;23(6):1080–9.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Green A, Williams G, Neale R, Hart V, Leslie D, Parsons P, et al. Daily sunscreen application and betacarotene supplementation in prevention of basal-cell and squamous-cell carcinomas of the skin: a randomised controlled trial. Lancet. 1999;354(9180):723–9.

    Article  CAS  PubMed  Google Scholar 

  54. van der Pols JC, Williams GM, Pandeya N, Logan V, Green AC. Prolonged prevention of squamous cell carcinoma of the skin by regular sunscreen use. Cancer Epidemiol Biomarkers Prev. 2006;15(12):2546–8.

    Article  PubMed  Google Scholar 

  55. Davis MM, Hanke CW, Zollinger TW, Montebello JF, Hornback NB, Norins AL. Skin cancer in patients with chronic radiation dermatitis. J Am Acad Dermatol. 1989;20(4):608–16.

    Article  CAS  PubMed  Google Scholar 

  56. Rowell NR. A follow-up study of superficial radiotherapy for benign dermatoses: recommendations for the use of X-rays in dermatology. Br J Dermatol. 1973;88(6):583–90.

    Article  CAS  PubMed  Google Scholar 

  57. Shore RE, Albert RE, Reed M, Harley N, Pasternack BS. Skin cancer incidence among children irradiated for ringworm of the scalp. Radiat Res. 1984;100(1):192–204.

    Article  CAS  PubMed  Google Scholar 

  58. Ron E, Modan B, Preston D, Alfandary E, Stovall M, Boice Jr JD. Radiation-induced skin carcinomas of the head and neck. Radiat Res. 1991;125(3):318–25.

    Article  CAS  PubMed  Google Scholar 

  59. Hildreth NG, Shore RE, Hempelmann LH, Rosenstein M. Risk of extrathyroid tumors following radiation treatment in infancy for thymic enlargement. Radiat Res. 1985;102(3):378–91.

    Article  CAS  PubMed  Google Scholar 

  60. Zackheim HS, Krobock E, Lang L. Cutaneous neoplasms in the rat produced by Grenz ray and 80 Kv X-ray. J Invest Dermatol. 1964;43:519–34.

    Article  CAS  PubMed  Google Scholar 

  61. Berg D, Otley CC. Skin cancer in organ transplant recipients: epidemiology, pathogenesis, and management. J Am Acad Dermatol. 2002;47(1):1–17. quiz 8–20.

    Article  PubMed  Google Scholar 

  62. Brewer JD, Colegio OR, Phillips PK, Roenigk RK, Jacobs MA, Van de Beek D, et al. Incidence of and risk factors for skin cancer after heart transplant. Arch Dermatol. 2009;145(12):1391–6.

    Article  PubMed  PubMed Central  Google Scholar 

  63. Martinez JC, Otley CC, Stasko T, Euvrard S, Brown C, Schanbacher CF, et al. Defining the clinical course of metastatic skin cancer in organ transplant recipients: a multicenter collaborative study. Arch Dermatol. 2003;139(3):301–6.

    Article  PubMed  Google Scholar 

  64. Lampros TD, Cobanoglu A, Parker F, Ratkovec R, Norman DJ, Hershberger R. Squamous and basal cell carcinoma in heart transplant recipients. J Heart Lung Transplant. 1998;17(6):586–91.

    CAS  PubMed  Google Scholar 

  65. Bouwes Bavinck JN, Hardie DR, Green A, Cutmore S, MacNaught A, O’Sullivan B, et al. The risk of skin cancer in renal transplant recipients in Queensland, Australia. A follow-up study. Transplantation. 1996;61(5):715–21.

    Article  CAS  PubMed  Google Scholar 

  66. Ong CS, Keogh AM, Kossard S, Macdonald PS, Spratt PM. Skin cancer in Australian heart transplant recipients. J Am Acad Dermatol. 1999;40(1):27–34.

    Article  CAS  PubMed  Google Scholar 

  67. Carroll RP, Ramsay HM, Fryer AA, Hawley CM, Nicol DL, Harden PN. Incidence and prediction of nonmelanoma skin cancer post-renal transplantation: a prospective study in Queensland, Australia. Am J Kidney Dis. 2003;41(3):676–83.

    Article  PubMed  Google Scholar 

  68. Herrero JI, Espana A, Quiroga J, Sangro B, Pardo F, Alvarez-Cienfuegos J, et al. Nonmelanoma skin cancer after liver transplantation. Study of risk factors. Liver Transpl. 2005;11(9):1100–6.

    Article  PubMed  Google Scholar 

  69. Durando B, Reichel J. The relative effects of different systemic immunosuppressives on skin cancer development in organ transplant patients. Dermatol Ther. 2005;18(1):1–11.

    Article  PubMed  Google Scholar 

  70. Hofbauer GF, Bouwes Bavinck JN, Euvrard S. Organ transplantation and skin cancer: basic problems and new perspectives. Exp Dermatol. 2010;19(6):473–82.

    Article  PubMed  Google Scholar 

  71. Jensen P, Hansen S, Moller B, Leivestad T, Pfeffer P, Geiran O, et al. Skin cancer in kidney and heart transplant recipients and different long-term immunosuppressive therapy regimens. J Am Acad Dermatol. 1999;40(2 Pt 1):177–86.

    Article  CAS  PubMed  Google Scholar 

  72. Euvrard S, Morelon E, Rostaing L, Goffin E, Brocard A, Tromme I, et al. Sirolimus and secondary skin-cancer prevention in kidney transplantation. N Engl J Med. 2012;367(4):329–39.

    Article  CAS  PubMed  Google Scholar 

  73. Campbell SB, Walker R, Tai SS, Jiang Q, Russ GR. Randomized controlled trial of sirolimus for renal transplant recipients at high risk for nonmelanoma skin cancer. Am J Transplant. 2012;12(5):1146–56.

    Article  CAS  PubMed  Google Scholar 

  74. Gu YH, Du JX, Ma ML. Sirolimus and non-melanoma skin cancer prevention after kidney transplantation: a meta-analysis. Asian Pac J Cancer Prev. 2012;13(9):4335–9.

    Article  PubMed  Google Scholar 

  75. Schena FP, Pascoe MD, Alberu J, del Carmen RM, Oberbauer R, Brennan DC, et al. Conversion from calcineurin inhibitors to sirolimus maintenance therapy in renal allograft recipients: 24-month efficacy and safety results from the CONVERT trial. Transplantation. 2009;87(2):233–42.

    Article  CAS  PubMed  Google Scholar 

  76. Bjornadal L, Lofstrom B, Yin L, Lundberg IE, Ekbom A. Increased cancer incidence in a Swedish cohort of patients with systemic lupus erythematosus. Scand J Rheumatol. 2002;31(2):66–71.

    Article  PubMed  Google Scholar 

  77. Singh H, Nugent Z, Demers AA, Bernstein CN. Increased risk of nonmelanoma skin cancers among individuals with inflammatory bowel disease. Gastroenterology. 2011;141(5):1612–20.

    Article  PubMed  Google Scholar 

  78. Peyrin-Biroulet L, Khosrotehrani K, Carrat F, Bouvier AM, Chevaux JB, Simon T, et al. Increased risk for nonmelanoma skin cancers in patients who receive thiopurines for inflammatory bowel disease. Gastroenterology. 2011;141(5):1621–8. e1–5.

    Article  CAS  PubMed  Google Scholar 

  79. Silverberg MJ, Leyden W, Warton EM, Quesenberry Jr CP, Engels EA, Asgari MM. HIV infection status, immunodeficiency, and the incidence of non-melanoma skin cancer. J Natl Cancer Inst. 2013;105(5):350–60.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  80. Mehrany K, Weenig RH, Lee KK, Pittelkow MR, Otley CC. Increased metastasis and mortality from cutaneous squamous cell carcinoma in patients with chronic lymphocytic leukemia. J Am Acad Dermatol. 2005;53(6):1067–71.

    Article  PubMed  Google Scholar 

  81. Mehrany K, Byrd DR, Roenigk RK, Weenig RH, Phillips PK, Nguyen TH, et al. Lymphocytic infiltrates and subclinical epithelial tumor extension in patients with chronic leukemia and solid-organ transplantation. Dermatol Surg. 2003;29(2):129–34.

    PubMed  Google Scholar 

  82. Mehrany K, Weenig RH, Pittelkow MR, Roenigk RK, Otley CC. High recurrence rates of squamous cell carcinoma after Mohs’ surgery in patients with chronic lymphocytic leukemia. Dermatol Surg. 2005;31(1):38–42.

    Article  CAS  PubMed  Google Scholar 

  83. Bridges N, Steinberg JJ. Aggressive squamous cell carcinoma of the skin after chronic lymphocytic leukemia. J Surg Oncol. 1986;33(1):27–30.

    Article  CAS  PubMed  Google Scholar 

  84. Velez NF, Karia PS, Vartanov AR, Davids MS, Brown JR, Schmults CD. Association of advanced leukemic stage and skin cancer tumor stage with poor skin cancer outcomes in patients with chronic lymphocytic leukemia. JAMA Dermatol. 2014;150(3):280–7.

    Article  PubMed  Google Scholar 

  85. Rowe DE, Carroll RJ, Jr Day CL. Prognostic factors for local recurrence, metastasis, and survival rates in squamous cell carcinoma of the skin, ear, and lip. Implications for treatment modality selection. J Am Acad Dermatol. 1992;26(6):976–90.

    Article  CAS  PubMed  Google Scholar 

  86. Jellouli-Elloumi A, Kochbati L, Dhraief S, Ben Romdhane K, Maalej M. Cancers arising from burn scars: 62 cases. Ann Dermatol Venereol. 2003;130(4):413–6.

    CAS  PubMed  Google Scholar 

  87. Edwards MJ, Hirsch RM, Broadwater JR, Netscher DT, Ames FC. Squamous cell carcinoma arising in previously burned or irradiated skin. Arch Surg. 1989;124(1):115–7.

    Article  CAS  PubMed  Google Scholar 

  88. Tseng WP, Chu HM, How SW, Fong JM, Lin CS, Yeh S. Prevalence of skin cancer in an endemic area of chronic arsenicism in Taiwan. J Natl Cancer Inst. 1968;40(3):453–63.

    CAS  PubMed  Google Scholar 

  89. Guo HR, Yu HS, Hu H, Monson RR. Arsenic in drinking water and skin cancers: cell-type specificity (Taiwan, ROC). Cancer Causes Control. 2001;12(10):909–16.

    Article  CAS  PubMed  Google Scholar 

  90. Karagas MR, Stukel TA, Morris JS, Tosteson TD, Weiss JE, Spencer SK, et al. Skin cancer risk in relation to toenail arsenic concentrations in a US population-based case-control study. Am J Epidemiol. 2001;153(6):559–65.

    Article  CAS  PubMed  Google Scholar 

  91. Surdu S, Fitzgerald EF, Bloom MS, Boscoe FP, Carpenter DO, Haase RF, et al. Occupational exposure to arsenic and risk of non-melanoma skin cancer in a multinational European study. Int J Cancer. 2013;133(9):2182–91.

    Article  CAS  PubMed  Google Scholar 

  92. Straif K, Benbrahim-Tallaa L, Baan R, Grosse Y, Secretan B, El Ghissassi F, et al. A review of human carcinogens--part C: metals, arsenic, dusts, and fibres. Lancet Oncol. 2009;10(5):453–4.

    Article  PubMed  Google Scholar 

  93. (ATSDR). AfTSaDR. ToxFAQs for polycyclic aromatic hydrocarbons 2011 [updated 10/18/2011; cited 2013 07/01]. http://www.atsdr.cdc.gov/toxfaqs/tf.asp?id=121&tid=25.

  94. Henry SA. Occupational cutaneous cancer attributable to certain chemicals in industry. Br Med Bull. 1947;4(5–6):389–401.

    CAS  PubMed  Google Scholar 

  95. Ross P. Occupational skin lesions due to pitch and tar. Br Med J. 1948;2(4572):369–74.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  96. Miller BG, Cowie HA, Middleton WG, Seaton A. Epidemiologic studies of Scottish oil shale workers: III. Causes of death. Am J Ind Med. 1986;9(5):433–46.

    Article  CAS  PubMed  Google Scholar 

  97. Karlehagen S, Andersen A, Ohlson CG. Cancer incidence among creosote-exposed workers. Scand J Work Environ Health. 1992;18(1):26–9.

    Article  CAS  PubMed  Google Scholar 

  98. Partanen T, Boffetta P. Cancer risk in asphalt workers and roofers: review and meta-analysis of epidemiologic studies. Am J Ind Med. 1994;26(6):721–40.

    Article  CAS  PubMed  Google Scholar 

  99. Hansen ES, Olsen JH, Tilt B. Cancer and non-cancer mortality of chimney sweeps in Copenhagen. Int J Epidemiol. 1982;11(4):356–61.

    Article  CAS  PubMed  Google Scholar 

  100. Voelter-Mahlknecht S, Scheriau R, Zwahr G, Koch B, Escobar Pinzon LC, Drexler H, et al. Skin tumors among employees of a tar refinery: the current data and their implications. Int Arch Occup Environ Health. 2007;80(6):485–95.

    Article  CAS  PubMed  Google Scholar 

  101. Kharazmi E, Fallah M, Sundquist K, Hemminki K. Familial risk of early and late onset cancer: nationwide prospective cohort study. BMJ. 2012;345:e8076.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  102. Hussain SK, Sundquist J, Hemminki K. The effect of having an affected parent or sibling on invasive and in situ skin cancer risk in Sweden. J Invest Dermatol. 2009;129(9):2142–7.

    Article  CAS  PubMed  Google Scholar 

  103. Milan T, Verkasalo PK, Kaprio J, Koskenvuo M, Pukkala E. Malignant skin cancers in the Finnish Twin Cohort: a population-based study, 1976–97. Br J Dermatol. 2002;147(3):509–12.

    Article  CAS  PubMed  Google Scholar 

  104. Cleaver JE, Thompson LH, Richardson AS, States JC. A summary of mutations in the UV-sensitive disorders: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy. Hum Mutat. 1999;14(1):9–22.

    Article  CAS  PubMed  Google Scholar 

  105. Kraemer KH, Lee MM, Scotto J. Xeroderma pigmentosum. Cutaneous, ocular, and neurologic abnormalities in 830 published cases. Arch Dermatol. 1987;123(2):241–50.

    Article  CAS  PubMed  Google Scholar 

  106. Kraemer KH, Lee MM, Andrews AD, Lambert WC. The role of sunlight and DNA repair in melanoma and nonmelanoma skin cancer. The xeroderma pigmentosum paradigm. Arch Dermatol. 1994;130(8):1018–21.

    Article  CAS  PubMed  Google Scholar 

  107. Gronskov K, Ek J, Brondum-Nielsen K. Oculocutaneous albinism. Orphanet J Rare Dis. 2007;2:43.

    Article  PubMed  PubMed Central  Google Scholar 

  108. Martinez-Garcia M, Montoliu L. Albinism in Europe. J Dermatol. 2013;40(5):319–24.

    Article  CAS  PubMed  Google Scholar 

  109. Nikolaou V, Stratigos AJ, Tsao H. Hereditary nonmelanoma skin cancer. Semin Cutan Med Surg. 2012;31(4):204–10.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  110. Mabula JB, Chalya PL, McHembe MD, Jaka H, Giiti G, Rambau P, et al. Skin cancers among Albinos at a University teaching hospital in Northwestern Tanzania: a retrospective review of 64 cases. BMC Dermatol. 2012;12:5.

    Article  PubMed  PubMed Central  Google Scholar 

  111. Luande J, Henschke CI, Mohammed N. The Tanzanian human albino skin. Natural history. Cancer. 1985;55(8):1823–8.

    Article  CAS  PubMed  Google Scholar 

  112. Fine JD, Johnson LB, Weiner M, Li KP, Suchindran C. Epidermolysis bullosa and the risk of life-threatening cancers: the National EB Registry experience, 1986–2006. J Am Acad Dermatol. 2009;60(2):203–11.

    Article  PubMed  Google Scholar 

  113. Yuen WY, Jonkman MF. Risk of squamous cell carcinoma in junctional epidermolysis bullosa, non-Herlitz type: report of 7 cases and a review of the literature. J Am Acad Dermatol. 2011;65(4):780–9.

    Article  PubMed  Google Scholar 

  114. Majewski S, Jablonska S. Skin autografts in epidermodysplasia verruciformis: human papillomavirus-associated cutaneous changes need over 20 years for malignant conversion. Cancer Res. 1997;57(19):4214–6.

    CAS  PubMed  Google Scholar 

  115. Dubina M, Goldenberg G. Viral-associated nonmelanoma skin cancers: a review. Am J Dermatopathol. 2009;31(6):561–73.

    Article  PubMed  Google Scholar 

  116. Ramoz N, Rueda LA, Bouadjar B, Montoya LS, Orth G, Favre M. Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis. Nat Genet. 2002;32(4):579–81.

    Article  CAS  PubMed  Google Scholar 

  117. Orth G. Genetics of epidermodysplasia verruciformis: insights into host defense against papillomaviruses. Semin Immunol. 2006;18(6):362–74.

    Article  CAS  PubMed  Google Scholar 

  118. Ferguson-Smith J. A case of multiple primary squamous-celled carcinomata in a young man, with spontaneous healing. Br J Dermatol. 1934;46:267–72.

    Article  Google Scholar 

  119. Ferguson-Smith MA, Wallace DC, James ZH, Renwick JH. Multiple self-healing squamous epithelioma. Birth Defects Orig Artic Ser. 1971;7(8):157–63.

    CAS  PubMed  Google Scholar 

  120. Goudie DR, D’Alessandro M, Merriman B, Lee H, Szeverenyi I, Avery S, et al. Multiple self-healing squamous epithelioma is caused by a disease-specific spectrum of mutations in TGFBR1. Nat Genet. 2011;43(4):365–9.

    Article  CAS  PubMed  Google Scholar 

  121. Stinco G, Governatori G, Mattighello P, Patrone P. Multiple cutaneous neoplasms in a patient with Rothmund-Thomson syndrome: case report and published work review. J Dermatol. 2008;35(3):154–61.

    Article  PubMed  Google Scholar 

  122. Karalis A, Tischkowitz M, Millington GW. Dermatological manifestations of inherited cancer syndromes in children. Br J Dermatol. 2011;164(2):245–56.

    Article  CAS  PubMed  Google Scholar 

  123. German J. Bloom’s syndrome. XX. The first 100 cancers. Cancer Genet Cytogenet. 1997;93(1):100–6.

    Article  CAS  PubMed  Google Scholar 

  124. Odenbro A, Bellocco R, Boffetta P, Lindelof B, Adami J. Tobacco smoking, snuff dipping and the risk of cutaneous squamous cell carcinoma: a nationwide cohort study in Sweden. Br J Cancer. 2005;92(7):1326–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  125. Marehbian J, Colt JS, Baris D, Stewart P, Stukel TA, Spencer SK, et al. Occupation and keratinocyte cancer risk: a population-based case-control study. Cancer Causes Control. 2007;18(8):895–908.

    Article  PubMed  Google Scholar 

  126. De Hertog SA, Wensveen CA, Bastiaens MT, Kielich CJ, Berkhout MJ, Westendorp RG, et al. Relation between smoking and skin cancer. J Clin Oncol. 2001;19(1):231–8.

    PubMed  Google Scholar 

  127. Karagas MR, Stukel TA, Greenberg ER, Baron JA, Mott LA, Stern RS. Risk of subsequent basal cell carcinoma and squamous cell carcinoma of the skin among patients with prior skin cancer. Skin Cancer Prevention Study Group. JAMA. 1992;267(24):3305–10.

    Article  CAS  PubMed  Google Scholar 

  128. Leonardi-Bee J, Ellison T, Bath-Hextall F. Smoking and the risk of nonmelanoma skin cancer: systematic review and meta-analysis. Arch Dermatol. 2012;148(8):939–46.

    Article  PubMed  Google Scholar 

  129. Ibiebele TI, van der Pols JC, Hughes MC, Marks GC, Green AC. Dietary fat intake and risk of skin cancer: a prospective study in Australian adults. Int J Cancer. 2009;125(7):1678–84.

    Article  CAS  PubMed  Google Scholar 

  130. Gamba CS, Stefanick M, Shikany J, Larson J, Linos E, Sims ST, et al. Low fat diet and skin cancer risk: the Women’s Health Initiative Randomized Controlled Dietary Modification Trial. Cancer Epidemiol Biomarkers Prev. 2013;22(9):1509–19.

    Article  CAS  PubMed  Google Scholar 

  131. Granger RH, Blizzard L, Fryer JL, Dwyer T. Association between dietary fat and skin cancer in an Australian population using case-control and cohort study designs. BMC Cancer. 2006;6:141.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  132. Ibiebele TI, van der Pols JC, Hughes MC, Marks GC, Williams GM, Green AC. Dietary pattern in association with squamous cell carcinoma of the skin: a prospective study. Am J Clin Nutr. 2007;85(5):1401–8.

    CAS  PubMed  Google Scholar 

  133. Aldabagh B, Angeles JG, Cardones AR, Arron ST. Cutaneous squamous cell carcinoma and human papillomavirus: is there an association? Dermatol Surg. 2013;39(1 Pt 1):1–23.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  134. de Koning MN, Weissenborn SJ, Abeni D, Bouwes Bavinck JN, Euvrard S, Green AC, et al. Prevalence and associated factors of betapapillomavirus infections in individuals without cutaneous squamous cell carcinoma. J Gen Virol. 2009;90(Pt 7):1611–21.

    Article  PubMed  CAS  Google Scholar 

  135. Andersson K, Waterboer T, Kirnbauer R, Slupetzky K, Iftner T, de Villiers EM, et al. Seroreactivity to cutaneous human papillomaviruses among patients with nonmelanoma skin cancer or benign skin lesions. Cancer Epidemiol Biomarkers Prev. 2008;17(1):189–95.

    Article  CAS  PubMed  Google Scholar 

  136. Alotaibi L, Provost N, Gagnon S, Franco EL, Coutlee F. Diversity of cutaneous human papillomavirus types in individuals with and without skin lesion. J Clin Virol. 2006;36(2):133–40.

    Article  CAS  PubMed  Google Scholar 

  137. Bouwes Bavinck JN, Neale RE, Abeni D, Euvrard S, Green AC, Harwood CA, et al. Multicenter study of the association between betapapillomavirus infection and cutaneous squamous cell carcinoma. Cancer Res. 2010;70(23):9777–86.

    Article  PubMed  CAS  Google Scholar 

  138. Paradisi A, Waterboer T, Sampogna F, Tabolli S, Simoni S, Pawlita M, et al. Seropositivity for human papillomavirus and incidence of subsequent squamous cell and basal cell carcinomas of the skin in patients with a previous nonmelanoma skin cancer. Br J Dermatol. 2011;165(4):782–91.

    Article  CAS  PubMed  Google Scholar 

  139. Iftner A, Klug SJ, Garbe C, Blum A, Stancu A, Wilczynski SP, et al. The prevalence of human papillomavirus genotypes in nonmelanoma skin cancers of nonimmuno suppressed individuals identifies high-risk genital types as possible risk factors. Cancer Res. 2003;63(21):7515–9.

    CAS  PubMed  Google Scholar 

  140. Pierceall WE, Goldberg LH, Ananthaswamy HN. Presence of human papilloma virus type 16 DNA sequences in human nonmelanoma skin cancers. J Invest Dermatol. 1991;97(5):880–4.

    Article  CAS  PubMed  Google Scholar 

  141. Arron ST, Ruby JG, Dybbro E, Ganem D, Derisi JL. Transcriptome sequencing demonstrates that human papillomavirus is not active in cutaneous squamous cell carcinoma. J Invest Dermatol. 2011;131(8):1745–53.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  142. Asgari MM, Kiviat NB, Critchlow CW, Stern JE, Argenyi ZB, Raugi GJ, et al. Detection of human papillomavirus DNA in cutaneous squamous cell carcinoma among immunocompetent individuals. J Invest Dermatol. 2008;128(6):1409–17.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  143. Forslund O, Iftner T, Andersson K, Lindelof B, Hradil E, Nordin P, et al. Cutaneous human papillomaviruses found in sun-exposed skin: beta-papillomavirus species 2 predominates in squamous cell carcinoma. J Infect Dis. 2007;196(6):876–83.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  144. Crook T, Wrede D, Tidy J, Scholefield J, Crawford L, Vousden KH. Status of c-myc, p53 and retinoblastoma genes in human papillomavirus positive and negative squamous cell carcinomas of the anus. Oncogene. 1991;6(7):1251–7.

    CAS  PubMed  Google Scholar 

  145. Holm R, Tanum G, Karlsen F, Nesland JM. Prevalence and physical state of human papillomavirus DNA in anal carcinomas. Mod Pathol. 1994;7(4):449–53.

    CAS  PubMed  Google Scholar 

  146. Noffsinger AE, Hui YZ, Suzuk L, Yochman LK, Miller MA, Hurtubise P, et al. The relationship of human papillomavirus to proliferation and ploidy in carcinoma of the anus. Cancer. 1995;75(4):958–67.

    Article  CAS  PubMed  Google Scholar 

  147. Shroyer KR, Brookes CG, Markham NE, Shroyer AL. Detection of human papillomavirus in anorectal squamous cell carcinoma. Correlation with basaloid pattern of differentiation. Am J Clin Pathol. 1995;104(3):299–305.

    Article  CAS  PubMed  Google Scholar 

  148. Frisch M, Glimelius B, van den Brule AJ, Wohlfahrt J, Meijer CJ, Walboomers JM, et al. Sexually transmitted infection as a cause of anal cancer. N Engl J Med. 1997;337(19):1350–8.

    Article  CAS  PubMed  Google Scholar 

  149. Madsen BS, van den Brule AJ, Jensen HL, Wohlfahrt J, Frisch M. Risk factors for squamous cell carcinoma of the penis--population-based case-control study in Denmark. Cancer Epidemiol Biomarkers Prev. 2008;17(10):2683–91.

    Article  CAS  PubMed  Google Scholar 

  150. Gregoire L, Cubilla AL, Reuter VE, Haas GP, Lancaster WD. Preferential association of human papillomavirus with high-grade histologic variants of penile-invasive squamous cell carcinoma. J Natl Cancer Inst. 1995;87(22):1705–9.

    Article  CAS  PubMed  Google Scholar 

  151. Ashinoff R, Li JJ, Jacobson M, Friedman-Kien AE, Geronemus RG. Detection of human papillomavirus DNA in squamous cell carcinoma of the nail bed and finger determined by polymerase chain reaction. Arch Dermatol. 1991;127(12):1813–8.

    Article  CAS  PubMed  Google Scholar 

  152. Zabawski Jr EJ, Washak RV, Cohen JB, Cockerell CJ, Brown SM. Squamous cell carcinoma of the nail bed: is finger predominance another clue to etiology? A report of 5 cases. Cutis. 2001;67(1):59–64.

    PubMed  Google Scholar 

  153. Anforth R, Fernandez-Penas P, Long GV. Cutaneous toxicities of RAF inhibitors. Lancet Oncol. 2013;14(1):e11–8.

    Article  CAS  PubMed  Google Scholar 

  154. Su F, Viros A, Milagre C, Trunzer K, Bollag G, Spleiss O, et al. RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors. N Engl J Med. 2012;366(3):207–15.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  155. Oberholzer PA, Kee D, Dziunycz P, Sucker A, Kamsukom N, Jones R, et al. RAS mutations are associated with the development of cutaneous squamous cell tumors in patients treated with RAF inhibitors. J Clin Oncol. 2012;30(3):316–21.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  156. Winston DJ, Chandrasekar PH, Lazarus HM, Goodman JL, Silber JL, Horowitz H, et al. Fluconazole prophylaxis of fungal infections in patients with acute leukemia. Results of a randomized placebo-controlled, double-blind, multicenter trial. Ann Intern Med. 1993;118(7):495–503.

    Article  CAS  PubMed  Google Scholar 

  157. Patel AR, Turner ML, Baird K, Gea-Banacloche J, Mitchell S, Pavletic SZ, et al. Voriconazole-induced phototoxicity masquerading as chronic graft-versus-host disease of the skin in allogeneic hematopoietic cell transplant recipients. Biol Blood Marrow Transplant. 2009;15(3):370–6.

    Article  PubMed  PubMed Central  Google Scholar 

  158. Frick MA, Soler-Palacin P, Martin Nalda A, Guarner ME, Nadal CF. Photosensitivity in immunocompromised patients receiving long-term therapy with oral voriconazole. Pediatr Infect Dis J. 2010;29(5):480–1.

    Article  PubMed  Google Scholar 

  159. Feist A, Lee R, Osborne S, Lane J, Yung G. Increased incidence of cutaneous squamous cell carcinoma in lung transplant recipients taking long-term voriconazole. J Heart Lung Transplant. 2012;31(11):1177–81.

    Article  PubMed  Google Scholar 

  160. Singer JP, Boker A, Metchnikoff C, Binstock M, Boettger R, Golden JA, et al. High cumulative dose exposure to voriconazole is associated with cutaneous squamous cell carcinoma in lung transplant recipients. J Heart Lung Transplant. 2012;31(7):694–9.

    Article  PubMed  PubMed Central  Google Scholar 

  161. Williams K, Mansh M, Chin-Hong P, Singer J, Arron ST. Voriconazole-associated cutaneous malignancy: a literature review on photocarcinogenesis in organ transplant recipients. Clin Infect Dis. 2014;58(7):997–1002.

    Article  PubMed  Google Scholar 

  162. Xie J, Qureshi AA, Li Y, Han J. ABO blood group and incidence of skin cancer. PLoS One. 2010;5(8):e11972.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  163. Wheeler BW, Allen J, Depledge MH, Curnow A. Radon and skin cancer in southwest England: an ecologic study. Epidemiology. 2012;23(1):44–52.

    Article  PubMed  Google Scholar 

  164. Duffield-Lillico AJ, Slate EH, Reid ME, Turnbull BW, Wilkins PA, Combs Jr GF, et al. Selenium supplementation and secondary prevention of nonmelanoma skin cancer in a randomized trial. J Natl Cancer Inst. 2003;95(19):1477–81.

    Article  CAS  PubMed  Google Scholar 

  165. van der Pols JC, Heinen MM, Hughes MC, Ibiebele TI, Marks GC, Green AC. Serum antioxidants and skin cancer risk: an 8-year community-based follow-up study. Cancer Epidemiol Biomarkers Prev. 2009;18(4):1167–73.

    Article  PubMed  CAS  Google Scholar 

  166. Karagas MR, Greenberg ER, Nierenberg D, Stukel TA, Morris JS, Stevens MM, et al. Risk of squamous cell carcinoma of the skin in relation to plasma selenium, alpha-tocopherol, beta-carotene, and retinol: a nested case-control study. Cancer Epidemiol Biomarkers Prev. 1997;6(1):25–9.

    CAS  PubMed  Google Scholar 

  167. Breslow RA, Alberg AJ, Helzlsouer KJ, Bush TL, Norkus EP, Morris JS, et al. Serological precursors of cancer: malignant melanoma, basal and squamous cell skin cancer, and prediagnostic levels of retinol, beta- carotene, lycopene, alpha-tocopherol, and selenium. Cancer Epidemiol Biomarkers Prev. 1995;4(8):837–42.

    CAS  PubMed  Google Scholar 

  168. Liang G, Nan H, Qureshi AA, Han J. Pre-diagnostic plasma 25-hydroxyvitamin D levels and risk of non-melanoma skin cancer in women. PLoS One. 2012;7(4):e35211.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  169. van der Pols JC, Russell A, Bauer U, Neale RE, Kimlin MG, Green AC. Vitamin D status and skin cancer risk independent of time outdoors: 11-year prospective study in an Australian community. J Invest Dermatol. 2013;133(3):637–41.

    Article  PubMed  CAS  Google Scholar 

  170. Eide MJ, Johnson DA, Jacobsen GR, Krajenta RJ, Rao DS, Lim HW, et al. Vitamin D and nonmelanoma skin cancer in a health maintenance organization cohort. Arch Dermatol. 2011;147(12):1379–84.

    Article  CAS  PubMed  Google Scholar 

  171. Tang JY, Fu T, Leblanc E, Manson JE, Feldman D, Linos E, et al. Calcium plus vitamin D supplementation and the risk of nonmelanoma and melanoma skin cancer: post hoc analyses of the women’s health initiative randomized controlled trial. J Clin Oncol. 2011;29(22):3078–84.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  172. Applebaum KM, Nelson HH, Zens MS, Stukel TA, Spencer SK, Karagas MR. Oral contraceptives: a risk factor for squamous cell carcinoma? J Invest Dermatol. 2009;129(12):2760–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  173. Asgari MM, Efird JT, Warton EM, Friedman GD. Potential risk factors for cutaneous squamous cell carcinoma include oral contraceptives: results of a nested case-control study. Int J Environ Res Public Health. 2010;7(2):427–42.

    Article  PubMed  PubMed Central  Google Scholar 

  174. de Vries E, Trakatelli M, Kalabalikis D, Ferrandiz L, Ruiz-de-Casas A, Moreno-Ramirez D, et al. Known and potential new risk factors for skin cancer in European populations: a multicentre case-control study. Br J Dermatol. 2012;167 Suppl 2:1–13.

    Article  PubMed  Google Scholar 

  175. Jensen AO, Thomsen HF, Engebjerg MC, Olesen AB, Sorensen HT, Karagas MR. Use of photosensitising diuretics and risk of skin cancer: a population-based case-control study. Br J Cancer. 2008;99(9):1522–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  176. Osterlind A, Hjalgrim H, Kulinsky B, Frentz G. Skin cancer as a cause of death in Denmark. Br J Dermatol. 1991;125(6):580–2.

    Article  CAS  PubMed  Google Scholar 

  177. Joseph MG, Zulueta WP, Kennedy PJ. Squamous cell carcinoma of the skin of the trunk and limbs: the incidence of metastases and their outcome. Aust N Z J Surg. 1992;62(9):697–701.

    Article  CAS  PubMed  Google Scholar 

  178. Weinstock MA. Epidemiologic investigation of nonmelanoma skin cancer mortality: the Rhode Island Follow-Back Study. J Invest Dermatol. 1994;102(6):6S–9.

    Article  CAS  PubMed  Google Scholar 

  179. Lewis KG, Weinstock MA. Trends in nonmelanoma skin cancer mortality rates in the United States, 1969 through 2000. J Invest Dermatol. 2007;127(10):2323–7.

    Article  CAS  PubMed  Google Scholar 

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Karia, P.S. (2016). Epidemiology and Outcomes of Cutaneous Squamous Cell Carcinoma. In: Schmults, C. (eds) High-Risk Cutaneous Squamous Cell Carcinoma. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-47081-7_1

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