Radionuclide Scintigraphy for Congenital Vascular Malformations



Radionuclide scintigraphy is a kind of diagnostic imaging modalities which utilizes radiopharmaceuticals or radiotracer and a gamma camera. For evaluating congenital vascular malformations (CVMs), there are several kinds of radionuclide scintigraphy to be clinically used: whole-body blood pool scan (WBBPS) and SPECT, transarterial lung perfusion scintigraphy (TLPS) and lymphoscintigraphy. It is clinically important to diagnose and to determine the type of CVMs, because the treatment plan and prognosis are different. Radionuclide scintigraphy is helpful to diagnose and to characterize CVMs. CVMs are a kind of systemic disease, which means that malformation can occur in any vessels of the whole body. Screening clinically unsuspected CVM lesions is also important, because they can progress during follow-up. Early detection of those lesions is helpful to determine the follow-up plan and early intervention. WBBPS is useful to screen blood-pooling CVMs due to its whole-body coverage, high sensitivity and relatively low costs. In blood-pooling CVMs, WBBPS is helpful to evaluate the response to therapy and disease progression, because of whole-body coverage, easy interpretation, capability of quantitation, convenient repetitive exam, non-invasiveness and relatively low costs. For extremity arteriovenous malformation, the shunt fraction measured by TLPS is useful to evaluate the response to therapy.


Congenital vascular malformation Radionuclide scintigraphy Whole-body blood pool scan Transarterial lung perfusion scintigraphy Lymphoscintigraphy Diagnosis Therapy response 


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© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  1. 1.Department of Nuclear Medicine, Samsung Medical CenterSungkyunkwan University School of MedicineSeoulSouth Korea

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