Skip to main content

Komplexes regionales Schmerzsyndrom

Eine aktuelle Übersicht

  • Chapter
Weiterbildung Schmerzmedizin
  • 2759 Accesses

Zusammenfassung

Ein komplexes regionales Schmerzsyndrom („complex regional pain syndrome“, CRPS) kann sich als Komplikation nach Frakturen und Verletzungen der Extremitäten, aber auch nach Nervenläsionen oder Schädigungen des Zentralnervensystems entwickeln. Als klinisches Bild findet sich eine charakteristische Trias, die autonome, sensorische und motorische Störungen umfasst. Die Diagnose wird in erster Linie klinisch anhand der Budapest-Kriterien gestellt. Die Therapie ist multidisziplinär und individuell zu planen. Verschiedene Methoden der physikalischen Medizin und medikamentöse Verfahren sind integrale Bestandteile des Therapiekonzepts. Medikamentöse Therapien orientieren sich an der spezifischen Symptomkonstellation und umfassen Glukokortikoide, Radikalfänger, die Pharmakotherapie von neuropathischen Schmerzen und Substanzen, die in den Knochenstoffwechsel eingreifen. In ausgewählten Fällen können invasive Verfahren eingesetzt werden.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 29.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 17.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Maihöfner C, Seifert F, Markovic K (2010) Complex regional pain syndromes: new pathophysiological concepts and therapies. Eur JNeurol 17(5):649–660

    Google Scholar 

  2. Marinus J, Moseley GL, Birklein Fet al (2011) Clinical features and pathophysiology of complex regional pain syndrome. Lancet NeuroI10(7):63764–8

    Google Scholar 

  3. Veldman PH, Reynen HM, Arntz IE et al (1993) Signs and symptoms of reflex sympathetic dystrophy: prospective study of 829 patients. Lancet 342(8878):1012–1016

    Article  PubMed  Google Scholar 

  4. Evans JA (1946) Reflex sympathetic dystrophy. Surg Gynecol Obstet 82:36–43

    PubMed  Google Scholar 

  5. Sudeck P (1900) Über die akute entzündliche Knochenatrophie. Arch Klin Chir 26:435–448

    Google Scholar 

  6. Stanton-Hicks M, Jänig W, Hassenbusch Set al (1995) Reflex sympathetic dystrophy: changing concepts and taxonomy. Pain 63(1):127–133

    Article  CAS  PubMed  Google Scholar 

  7. Eberle T, Doganci B, Krämer HH et al (2009) Warm and cold complex regional pain syndromes: differences beyond skin temperature? Neurology 72(6):505–512

    Article  PubMed  Google Scholar 

  8. Maihöfner C, Birklein F (2007) Komplex regionale Schmerzsyndrome: Neues zu Pathophysiologie und Therapie. Fortschr Neurol Psychiatr 75(6):331–342

    Article  PubMed  Google Scholar 

  9. Kolb L, Lang C, Seifert Fet al (2012) Cognitive correlates of"neglect-like syndrome" in patients with complex regional pain syndrome. Pain 153(5):1063–1073

    Article  PubMed  Google Scholar 

  10. Dijkstra PU, Groothoff JW, Duis HJ ten et al (2003) Ineidence of complex regional pain syndrome type I after fractures of the distal radius. Eur J Pain 7(5):457–462

    Article  PubMed  Google Scholar 

  11. Sandroni P, Benrud-Larson LM, McClelland RL et al (2003) Complex regional pain syndrome type I: incidence and prevalence in Olmsted county, a population-based study. Pain 103(1-2):199–207

    Google Scholar 

  12. Mos Mde, Bruijn AG, Huygen FJ et al (2007) The ineidence of complex regional pain syndrome: a population-based study. Pain 129:122–0

    Article  Google Scholar 

  13. Nickel FT, Maihöfner C (2010) Aktuelle Erkenntnisse zur Pathophysiologie des CRPS I. Handchir Mikrochir Plast Chir 42(1):8–14

    Article  PubMed  Google Scholar 

  14. ForouzanfarT, Kemler MA, Weber WE et al (2004) Spinal cord stimulation in complex regional pain syndrome: cervical and lumbar devices are comparably effective. Br JAnaesth 92:348–353

    Google Scholar 

  15. Furlan AD, Mailis A, Papagapiou M (2000) Are we paying a high price for surgical sympathectomy? Asystematic literature review of late complications. JPain 1(4):245–257

    Google Scholar 

  16. Geertzen JH, Bruijn-Kofman AT de, Bruijn HP de et al (1998) Stressfullife events and psychological dysfunction in complex regional pain syndrometype I. Clin JPain 14(2):143–147

    Google Scholar 

  17. Maihöfner C, Handwerker HO, Neundörfer Bet al (2005) Mechanical hyperalgesia in complex regional pain syndrome: a role forTNF-alpha? Neurology 65 (2):311–313

    Article  PubMed  Google Scholar 

  18. Alexander GM, Peterlin BL, Perreault MJ et al (2012) Changes in plasma cytokines and their soluble receptors in complex regional pain syndrome. J Pain 13(1):10–20

    Article  PubMed  Google Scholar 

  19. Uçeyler N, Eberle T, Rolke Ret al (2007) Differential expression patterns of cytokines in complex regional pain syndrome. Pain 132(12): 195–205

    Google Scholar 

  20. Parkitny L, McAuley JH, Di Pietro F et al (2013) Inflammation in complex regional pain syndrome: a systematic review and meta-analysis. Neurology 80(1):106–117

    Article  PubMed Central  PubMed  Google Scholar 

  21. Leis S, Weber M, Isselmann Aet al (2003) Substance-P-induced protein extravasation is bilaterally increased in complex regional pain syndrome. Exp NeuroI183(1):197–204

    Google Scholar 

  22. Leis S, Weber M, Schmelz M, Birklein F (2004) Faeilitated neurogenic inflammation in unaffected limbs of patients with complex regional pain syndrome. Neurosei Lett 359(3):16316–6

    Google Scholar 

  23. Birklein F, Schmelz M, Schifter Set al (2001) The important role of neuropeptides in complex regional pain syndrome. Neurology 57(12):2179218–4

    Article  Google Scholar 

  24. Fischer SGL, Perez RS, Nouta Jet al (2013) Oxidative stress in complex regional pain syndrome (CRPS): no systemically elevated levels of malondialdehyde, F2-isoprostanes and 80HdG in a selected sampie of patients. lnt JMol Sei 14:7784–7794

    Google Scholar 

  25. Schlereth T, Birklein F (2012) Mast cells: source of inflammation in complex regional pain syndrome? Anesthesiology 116(4):756–757

    Article  PubMed  Google Scholar 

  26. Moseley GL, Zalucki N, Birklein Fet al (2008) Thinking about movement hurts: the effect of motor imagery on pain and swelling in people with chronic arm pain. Arthritis Rheum 59(5):623–631

    PubMed  Google Scholar 

  27. Moseley GL, Gallace A, Spence C (2009) Space-based, but not armbased, shift in tactile processing in complex regional pain syndrome and its relations hip to cooling ofthe affected limb. Brain 132(Pt 11):3142315–1

    Google Scholar 

  28. Kohr D, Singh P, Tschernatsch Met al (2011) Autoimmunity against the ß2 adrenergic receptor and muscarinic-2 receptor in complex regional pain syndrome. Pain 152(12):2690270–0

    Article  Google Scholar 

  29. Kohr D, Tschernatsch M, Schmitz K et al (2009) Autoantibodies in complex regional pain syndrome bind to adifferentiation-dependent neuronal surface autoantigen. Pain 143(3):246–251

    Article  PubMed  Google Scholar 

  30. Rommel 0, Gehling M, Dertwinkel Ret al (1999) Hemisensory impairment in patients with complex regional pain syndrome. Pain 80(1-2):9510–1

    Google Scholar 

  31. Maihöfner C, Handwerker HO, Neundörfer Bet al (2003) Patterns of cortical reorganization in complex regional pain syndrome. Neurology 61(12):1707–1715

    Article  PubMed  Google Scholar 

  32. Maihöfner C, Handwerker HO, Neundörfer Bet al (2004) Cortical reorganization during recoveryfrom complex regional pain syndrome. Neurology 63(4):693–701

    Article  PubMed  Google Scholar 

  33. Pleger B, Tegenthoff M, Ragert Pet al (2005) Sensorimotor retuning [corrected] in complex regional pain syndrome paralleis pain reduction. Ann NeuroI57(3):425–429

    Google Scholar 

  34. Maihöfner C, Forster C, Birklein Fet al (2005) Brain processing during mechanical hyperalgesia in complex regional pain syndrome: afunctional MRI study. Pain 114(1-2):93–103

    PubMed  Google Scholar 

  35. Maihöfner C, Handwerker HO, Birklein F (2006) Functional imaging of allodynia in complex regional pain syndrome. Neurology 66(5):711–717

    Article  PubMed  Google Scholar 

  36. Reinersmann A, Landwehrt J, Krumova EK et al (2012) Impaired spatial body representation in complex regional pain syndrome type 1 (CRPS 1). Pain 153(11):2174–2181

    Article  PubMed  Google Scholar 

  37. Huehne K, Schaal U, Leis Set al (2010) Lack of genetic assoeiation of neutral endopeptidase (NEP) with complex regional pain syndrome (CRPS). Neurosci Lett472(1):19–23

    Google Scholar 

  38. Rooij AM de, Florencia Gosso M, Haasnoot GW et al (2009) HLA-B62 and HLA-DQ8 are associated with complex regional pain syndrome with fixed dystonia. Pain 145(12): 82–85

    Article  PubMed  Google Scholar 

  39. Rooijen DE van, Roelen DL, Verduijn Wet al (2012) Genetic HLA associations in complex regional pain syndrome with and without dystonia. JPain 13(8):784–789

    Google Scholar 

  40. Peterlin BL, Rosso AL, Nair Set al (2010) Migraine may be a riskfactor for the development of complex regional pain syndrome. Cephalalgia 30(2):214–223

    PubMed Central  PubMed  Google Scholar 

  41. Harden RN, Bruehl S, Stanton-Hicks Met al (2007) Proposed new diagnostic criteria for complex regional pain syndrome. Pain Med 8(4):326–331

    Article  PubMed  Google Scholar 

  42. Harden RN, Bruehl S, Perez RS et al (2010) Validation of proposed diagnostic criteria (the"Budapest Criteria") for complex regional pain syndrome. Pain 150:268–274

    Article  PubMed Central  PubMed  Google Scholar 

  43. Peltz E, Seifert F, Maihöfner C (2012) Leitfaden zur Diagnostik des komplexen regionalen Schmerzsyndroms. Handchir Mikrochir Plast Chir 44(3):135–141

    Article  PubMed  Google Scholar 

  44. Schürmann M, Zaspel J, Löhr Pet al (2007) Imaging in early posttraumatic complex regional pain syndrome: acomparison of diagnostic methods. Clin JPain 23(5):449–457

    Google Scholar 

  45. Ringer R, Wertli M, Bachmann LM et al (2012) Concordance of qualitative bone scintigraphy results with presence of c1inical complex regional pain syndrome 1: meta-analysis of test accuracy studies. Eur JPain 16(10):1347–1356

    Google Scholar 

  46. Wüppenhorst N, Maier C, Frettlöh J et al (2010) Sensitivity and specificity of 3-phase bone scintigraphy in the diagnosis of complex regional pain syndrome ofthe upper extremity. Clin JPain 26(3):182–189

    Google Scholar 

  47. Gierthmühlen J, Maier C, Baron R et al (2012) Sensory signs in complex regional pain syndrome and peripheral nerve injury. Pain 153(4):76577–4

    Article  Google Scholar 

  48. Rolke R, Baron R, Maier Cet al (2006) Quantitative sensorytesting in the German Research Network on Neuropathic Pain (DFNS): standardized protocol and reference values. Pain 123(3):231–243

    Article  PubMed  Google Scholar 

  49. Wasner G, Schattschneider J, Heckmann Ket al (2001) Vascular abnormalities in reflex sympathetic dystrophy (CRPS 1): mechanisms and diagnostic value. Brain 124(Pt 3):58759–9

    Article  Google Scholar 

  50. Oerlemans HM, Oostendorp RA, Boo Tde et al (1999) Pain and reduced mobility in complex regional pain syndrome I: outcome ofa prospective randomised controlled c1inical trial of adjuvant physical therapy versus occupational therapy. Pain 83(1):77–83

    Google Scholar 

  51. Robaina FJ, Rodriguez JL, Vera JA de et al (1989) Transcutaneous electrical nerve stimulation and spinal cord stimulation for pain relief in reflex sympathetic dystrophy. Stereotact Funct Neurosurg 52(1):53–62

    Article  CAS  PubMed  Google Scholar 

  52. Maihöfner C, Baron R, DeCol R et al (2007) The motor system shows adaptive changes in complex regional pain syndrome. Brain 130(Pt 10):2671–2687

    Article  PubMed  Google Scholar 

  53. Cacchio A, Blasis Ede, Necozione S et al (2009) Mirror therapyfor chronic complex regional pain syndrome type 1and stroke. NEngl JMed 361 (6):634–636

    Article  Google Scholar 

  54. McCabe CS, Haigh RC, Ring EF et al (2003) Acontrolled pilot study of the utility of mirror visual feedback in the treatment of complex regional pain syndrome (type 1). Rheumatology (Oxford) 42(1):97–101

    Google Scholar 

  55. Moseley GL (2006) Graded motor imageryfor pathologic pain: a randomized controlled trial. Neurology 67(12):2129–2134

    Article  PubMed  Google Scholar 

  56. Johnson S, Hall J, Barnett Set al (2012) Using graded motor imagery for complex regional pain syndrome in c1inical practice: failure to improve pain. Eur JPain 16(4):550–561

    Google Scholar 

  57. Maihöfner C, SpeckV (2012) Graded motor imagery for complex regional pain syndrome: where are we now? Eur JPain 16(4):461–462

    Google Scholar 

  58. Ek J, Gijn JC van, Samwel Het al (2009) Pain exposure physical therapy may be a safe and effective treatment for longstanding complex regional pain syndrome type 1: acase series. Clin RehabiI23(12):1059106–6

    Google Scholar 

  59. Speck V, Maihöfner C (2012) Erhöhte Prävalenz der posttraumatischen Belastungsstörung bei Patienten mit CRPS. Schmerz 26 (Suppl1 ):P14.3

    Google Scholar 

  60. Christensen K, Jensen EM, Noer I (1982) The reflex dystrophy syndrome response to treatment with systemic corticosteroids. Acta Chir Scand 148(8):653–655

    PubMed  Google Scholar 

  61. Zuurmond WW, Langendijk PN, Bezemer PD et al (1996) Treatment of acute reflex sympathetic dystrophy with DMSO 50% in afatty cream. Acta Anaesthesiol Scand 40(3):364–367

    Article  PubMed  Google Scholar 

  62. Zollinger PE, TUinebreijerWE, Kreis RW et al (1999) Effect of vitamin Con frequency of reflex sympathetic dystrophy in wrist fractures: a randomised trial. Lancet 354(9195):2025202–8

    Article  Google Scholar 

  63. Perez RS, Zuurmond WW, Bezemer PD et al (2003) The treatment of complex regional pain syndrome type I with free radical scavengers: a randomized controlled study. Pain 102:297–307

    Article  PubMed  Google Scholar 

  64. Attal N, Cruccu G, Baron Ret al (2010) EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision. Eur JNeurol 17(9):1113-e88

    Google Scholar 

  65. Mellick GA, Mellicy LB, Mellick LB (1995) Gabapentin in the management of reflex sympathetic dystrophy. JPain Symptom Manage 10(4):265–266

    Google Scholar 

  66. Gobelet C, Waldburger M, Meier JL (1992) The effect of adding calcitonin to physical treatment on reflex sympathetic dystrophy. Pain 48(2):171–175

    Article  PubMed  Google Scholar 

  67. Brunner F, Schmid A, Kissling Ret al (2009) Biphosphonates for the therapy of complex regional pain syndrome 1- systematic review. Eur JPain 13(1):17–21

    Google Scholar 

  68. Birthi P, Sioan P, Salles S (2012) Subcutaneous botulinum toxin Afor the treatment of refractory complex regional pain syndrome. PM R 4(6):446–449

    Article  PubMed  Google Scholar 

  69. Hilten BJ van, Beek WJ van de, Hoff JI et al (2000) Intrathecal baclofen for the treatment of dystonia in patients with reflex sympathetic dystrophy. NEngl JMed 343(9):625–630

    Google Scholar 

  70. Rijn MA van, Munts AG, Marinus J et al (2009) Intrathecal baclofen for dystonia of complex regional pain syndrome. Pain 143(1-2):41–47

    PubMed  Google Scholar 

  71. Sigtermans MJ, Hilten JJ van, Bauer MC et al (2009) Ketamine produces effective and long-term pain relief in patients with complex regional pain syndrome type 1. Pain 145(3):30431–1

    Article  Google Scholar 

  72. Goebel A, Baranowski A, Maurer K et al (2010) Intravenous immunoglobulin treatment of the complex regional pain syndrome: a randomized trial. Ann Intern Med 152(3):152–158

    Article  PubMed  Google Scholar 

  73. Miclescu AA, Nordquist L, Hysing E et al (2013) Targeting oxidative injury and cytokines' activity in the treatment with anti-tumor necrosis factor-a antibody for complex regional pain syndrome 1. Pain Pract 13(8):641–648

    Google Scholar 

  74. Eisenberg E, Sandler I, Treister R et al (2013) Anti tumor necrosis factor - alpha adalimumab for complex regional pain syndrome type 1 (CRPS-I): acase series. Pain Pract 13(8):649–656

    Article  PubMed  Google Scholar 

  75. Dirckx M, Groeneweg G, Wesseldijk Fet al (2013) Report of a preliminary discontinued double-blind, randomized, placebo-controlled trial of the anti-TNF-a chimeric monoclonal antibody infliximab in complex regional pain syndrome. Pain Pract 13(8):633–640

    Google Scholar 

  76. Stanton TR, Wand BM, Carr DB et al (2013) Local anaesthetic sympathetic blockade for complex regional pain syndrome. Cochrane Database Syst Rev:CD004598

    Google Scholar 

  77. TronnierV, Baron R, Birklein Fet al (2011) Epidurale Rückenmarkstimulation zurTherapie chronischer Schmerzen. Zusammenfassung der S3-Leitlinie. Schmerz 25(5):484–492

    Google Scholar 

  78. Kemler MA, Vet HC de, Barendse GA et al (2004) The effect of spinal cord stimulation in patients with chronic reflex sympathetic dystrophy: two years' follow-up of the randomized controlled trial. Ann NeuroI55:13–18

    Google Scholar 

  79. Hassenbusch SJ, Stanton-Hicks M, Schoppa Det al (1996) Long-term results of peripheral nerve stimulation for reflex sympathetic dystrophy. JNeurosurg 84(3):415–423

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Maihöfner, C. (2015). Komplexes regionales Schmerzsyndrom. In: Weiterbildung Schmerzmedizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-46517-2_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-46517-2_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-46516-5

  • Online ISBN: 978-3-662-46517-2

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics