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Properties of Nucleic Acid Amphiphiles and Their Biomedical Applications

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Aptamers Selected by Cell-SELEX for Theranostics

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Abstract

Nucleic acid-based amphiphiles, which consist of nucleic acids covalently linked to lipophilic lipid molecules, have demonstrated unique physicochemical and biological properties and are emerging as new types of materials in biomedical applications. These types of hybrid materials combine the functions and properties from both hydrophilic nucleic acids and hydrophobic lipid tails and thus are developed to carry therapeutic drugs, to penetrate cell membranes, to decorate the cell surface, and to interact with endogenous proteins. These functional amphiphiles have demonstrated potentials in extending the usage of traditional nucleic acids. In this chapter, we highlight the recent advances with an emphasis on their synthesis, self-assemble properties, and biomedical applications. Specifically, we focus on illustrating the structure–function relationship which provides the foundation for rational design of nucleic acid amphiphiles in future applications in the biomedical field.

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Authors and Affiliations

  1. Department of Chemical Engineering and Materials Science, Wayne State University, Detroit, MI, 48202, USA

    Haipeng Liu

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  1. Haipeng Liu
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Correspondence to Haipeng Liu .

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Editors and Affiliations

  1. Department of Chemistry, Hunan University, Molecular Science and Biomedicine Laboratory, State Key Laboratory for Chemo/Bio-Sensing and Chemometrics College of Chemistry and Chemical Engineering, Changsha, China & University of Florida, Gainesville, Florida, USA

    Weihong Tan

  2. Institute of Chemistry, Chinese Academy of Sciences, Beijing, China

    Xiaohong Fang

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Liu, H. (2015). Properties of Nucleic Acid Amphiphiles and Their Biomedical Applications. In: Tan, W., Fang, X. (eds) Aptamers Selected by Cell-SELEX for Theranostics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-46226-3_7

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