Concept and Scientific Background of Personalized Medicine
Tailoring a treatment to the special needs of a given individual has always been the overall goal in life and medical sciences. Progress in our understanding the pathophysiology and genetics of complex diseases has strongly contributed to consider many diseases under a new light and to project more sofisticated therapeutic approaches. Providing the right drug at the right dosis to the right patient the right time point is the substantial basis for personalized medicine, away from the classical, more or less evidence based “one size fits for all” model. Although the goal of personalized medicine sound obvious for all stakeholders, the way to reach it remains highly complex and needs the development of many different tools, including biobanks and the identification and validation of biomarkers. We will assist to a progressive change in our definition of the diseases, moving from the phenotypic taxonomy to a molecular taxonomy. The ultimate result will end in a more or less pronounced stratification of complex diseases into variable groups of patients, all characterized by various combinations of phenotypic and endophenotypic profiles. Moreover, this new medical evolutionary process will also induce a shift from the current curative medicine towards a more predictive, preventive, personalized and participatory (P4) medicine.
KeywordsAtopic Dermatitis Personalized Medicine Molecular Taxonomy Putative Therapeutic Target System Biologic Approach