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Biology of the Basement Membrane Zone

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Blistering Diseases

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Abstract

The dermal-epidermal basement membrane contains specialized components which provide added adhesion to counteract disruptive external forces. These include specialized laminins, collagens, integrins, as well as other unique structural components which together serve to connect the intermediate filament network of the basal keratinocyte cytoskeleton to the interstitial collagen network of the papillary dermis. Damage to the dermal-epidermal basement membrane, whether through inherited genetic mutations or acquired autoimmune disorders, results in disruption of dermal-epidermal cohesion and blistering disease. The dermal-epidermal basement membrane also plays a key role in dynamic processes such as skin development, carcinoma invasion, and wound healing.

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  1. Department of Dermatology, Stanford University School of Medicine and VA Palo Alto Health Care System, Stanford, CA, USA

    Sana Hashmi BS & M. Peter Marinkovich MD

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  1. Department of Dermatology, St George Hospital, University of New South Wales, Sydney, New South Wales, Australia

    Dédée F. Murrell

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Hashmi, S., Marinkovich, M.P. (2015). Biology of the Basement Membrane Zone. In: Murrell, D. (eds) Blistering Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45698-9_1

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