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Graphene in Drug Delivery, Cellular Imaging, Bacteria Inhibition, Versatile Targets Bioassays

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Biocompatible Graphene for Bioanalytical Applications

Part of the book series: SpringerBriefs in Molecular Science ((BRIEFSMOLECULAR))

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Abstract

The evaluation of potential risk of graphene to human body has been carried out due to its exceptional promise in various applications, such as glucose detection, drug delivery, and cellular imaging. Small nanosheets entered cells mainly through clathrin-mediated endocytosis, and the increase in graphene size enhanced phagocytotic uptake of the nanosheets. Cellular imaging and drug delivery have also been achieved by using biocompatible material-grafted graphene platforms. Graphene can also be used in pathogen and bacteria inhibition in the form of graphene nanowalls deposited on stainless steel substrates. Recently, versatile bioassay represents one of the main challenges in bioanalytical applications. The large surface area and universal fluorescence quenching ability of graphene sheets enable it to be an efficient platform for multiplex targets assay in a fluorescent manner. Based on this, multiplex analytes, such as DNA, thrombin, Ag+, Hg2+, cysteine and DNA, thrombin, ATP in logic gate operations, have been successfully detected with high sensitivity and simplicity.

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Authors and Affiliations

  1. Engineering Laboratory for Modern Analytical Techniques c/o State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Renmin St. 5625, Changchun, 130022, China

    Yuwei Hu, Fenghua Li, Dongxue Han & Li Niu

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  1. Yuwei Hu
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  2. Fenghua Li
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  3. Dongxue Han
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  4. Li Niu
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Correspondence to Yuwei Hu .

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Hu, Y., Li, F., Han, D., Niu, L. (2015). Graphene in Drug Delivery, Cellular Imaging, Bacteria Inhibition, Versatile Targets Bioassays. In: Biocompatible Graphene for Bioanalytical Applications. SpringerBriefs in Molecular Science. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45695-8_6

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