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Evidence for a Link of SDPR and Cytoskeleton

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Advances in Applied Biotechnology

Part of the book series: Lecture Notes in Electrical Engineering ((LNEE,volume 332))

Abstract

Serum deprivation response (SDPR) is a plasma membrane binding protein and a substrate of protein kinase C (PKC) phosphorylation, which recruits polymerase I and transcript release factor (PTRF) to caveolae to stabilize and define their morphology. But how they were transported to membrane remain unclear. In order to clarify the link of SDPR and cytoskeleton, we observed the localized relationship between SDPR and cytoskeleton proteins by Immunofluorescence. Here, we discovered that SDPR colocalizes with cortactin (CTTN) in A7r5. Interestingly, SDPR was found to be highly concentrated in podosomes and dorsal ruffles induced by Phorbol 12, 13-dibutyrate (PDBu), and platelet-derived growth factor (PDGF), respectively, which suggest a possible role of SDPR in cell motility and cell invasion.

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Acknowledgments

This study was supported by National Natural Science Foundation of China (NO. 31340001, 31271448) and research start-up fund of Tianjin University of Science and Technology.

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Authors and Affiliations

  1. Key Lab of Industrial Fermentation Microbiology of the Ministry of Education, College of Bioengineering, Tianjin University of Science and Technology, Tianjin, 300457, China

    Baoxia Zhang, Jun Zhu, Liqiao Ma, Yuyin Li, Aipo Diao & Yinchuan Li

Authors
  1. Baoxia Zhang
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  2. Jun Zhu
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  3. Liqiao Ma
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  4. Yuyin Li
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  5. Aipo Diao
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  6. Yinchuan Li
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Corresponding authors

Correspondence to Aipo Diao or Yinchuan Li .

Editor information

Editors and Affiliations

  1. Tianjin University of Science and Technology, Tianjin, China

    Tong-Cun Zhang

  2. SBI ALApromo, Tokyo, Japan

    Motowo Nakajima

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© 2015 Springer-Verlag Berlin Heidelberg

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Zhang, B., Zhu, J., Ma, L., Li, Y., Diao, A., Li, Y. (2015). Evidence for a Link of SDPR and Cytoskeleton. In: Zhang, TC., Nakajima, M. (eds) Advances in Applied Biotechnology. Lecture Notes in Electrical Engineering, vol 332. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45657-6_17

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