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VIPoma and PPoma

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Neuroendocrine Tumours

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Abstract

Gastroenteropancreatic Neuroendocrime Tumours (NETs) include tumours which are able to secrete specific peptides. These molecules may have a normal function, but they can induce symptoms when their secretion reaches high levels. Amongst these kinds of NETs, VIPoma and PPoma are rare forms, which could be confused with other malignancies or other diseases. VIPoma is characterized by the Verner-Morrison syndrome, including watery diarrhoea and electrolytic changes. These symptoms are associated with high VIP plasma levels, even though other peptides could be increased. Just few data are available to explain the molecular mechanisms inducing VIPoma onset. A specific treatment is not available for this NET. However, the symptoms associated with this malignancy can be managed by hydration and the correction of electrolytic and biochemical changes. Other strategies are similar to those applicable for all NETs. For PPoma the available clinical data are less. Anyway the onset of specific symptoms is infrequent. PPoma is usually treated by surgery.

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Authors and Affiliations

  1. Oncology Department and Multidisciplinary Oncology Center of Antwerp (MOCA), Antwerp University Hospital, Wilrijkstraat 10, Edegem, 2650, Belgium

    Christian Rolfo, Konstantinos Papadimitriou & Marc Peeters

  2. Section of Medical Oncology, Department of Surgical, Oncological and Stomatological Sciences, University of Palermo, Palermo, Italy

    Giuseppe Bronte & Antonio Russo

  3. Pathology Institute, Sourasky Medical Center, Tel Aviv, Israel

    Leonor Leider

  4. Pathology Department and MOCA, Antwerp University Hospital, Edegem, Belgium

    Patrick Pauwels

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  1. Christian Rolfo
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  2. Giuseppe Bronte
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  4. Patrick Pauwels
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  5. Konstantinos Papadimitriou
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  6. Antonio Russo
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  7. Marc Peeters
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Correspondence to Marc Peeters or Marc Peeters .

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Editors and Affiliations

  1. Department of Medical Oncology, Hacettepe University Cancer Institute, Ankara, Turkey

    Suayib Yalcin

  2. Department of Endocrine Oncology, Uppsala University Hospital, Uppsala, Sweden

    Kjell Öberg

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Rolfo, C. et al. (2015). VIPoma and PPoma. In: Yalcin, S., Öberg, K. (eds) Neuroendocrine Tumours. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45215-8_14

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  • DOI: https://doi.org/10.1007/978-3-662-45215-8_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-45214-1

  • Online ISBN: 978-3-662-45215-8

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