Abstract
Metabolic and genetic engineering and further other genomics, transcriptomics, and metabolomics tools still need to be further developed to provide more useful information and new ways on enhancing lipid production in oleaginous microorganisms, optimizing fatty acid (FA) profiles, enhancing lipid accumulation, and improving the use of low-cost raw materials as lignocellulosic hydrolysates. Several oleaginous organisms have been described as good lipid producers, being the fast ones the yeasts. However the kinetics for this production is much slower than that required for industrial processes, unless the products are sold at high competitive prices (fine chemicals, cosmetics, and food), covering the costs for the long residential bioreactor times.
Microalgal cultivation in heterotrophic systems is able to use organic carbon sources, sugars, or organic acids, and this cultivation mode offers some advantages over autotrophic cultivation including increased lipid productivity, besides good control of the cultivation process and low cost for harvesting the biomass, since higher cell density is obtained. However, the feasibility of large-scale cultures of microalgae in heterotrophic conditions is still limited by, among other things, the high cost of organic substrates used in this type of cultivation, unless urban/agricultural/industrial wastes are used as lignocellulose and wastewater and sewage are used as carbon or mineral sources.
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Coradini, A.L.V. et al. (2015). Microorganism for Bioconversion of Sugar Hydrolysates into Lipids. In: Kamm, B. (eds) Microorganisms in Biorefineries. Microbiology Monographs, vol 26. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45209-7_3
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DOI: https://doi.org/10.1007/978-3-662-45209-7_3
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