Abstract
The following three chapters deal with the development of treatments for age-related macular degeneration (AMD or ARMD) and related conditions. Here we present a description of these conditions that best reflects the understanding of these diseases by the authors of these chapters.
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Age-Related Eye Disease Study Research G (2001) A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol 119(10):1417–1436
Age-Related Eye Disease Study 2 Research G (2013) Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. JAMA 309(19):2005–2015. doi:10.1001/jama.2013.4997
Ambati J, Fowler BJ (2012) Mechanisms of age-related macular degeneration. Neuron 75(1):26–39. doi:10.1016/j.neuron.2012.06.018
Anderson DH, Radeke MJ, Gallo NB, Chapin EA, Johnson PT, Curletti CR, Hancox LS, Hu J, Ebright JN, Malek G, Hauser MA, Rickman CB, Bok D, Hageman GS, Johnson LV (2010) The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited. Prog Retin Eye Res 29(2):95–9112
Coleman DJ, Silverman RH, Rondeau MJ, Lloyd HO, Khanifar AA, Chan RV (2013) Age-related macular degeneration: choroidal ischaemia? Br J Ophthalmol 97(8):1020–1023. doi:10.1136/bjophthalmol-2013-303143
Damico FM, Gasparin F, Scolari MR, Pedral LS, Takahashi BS (2012) New approaches and potential treatments for dry age-related macular degeneration. Arq Bras Oftalmol 75(1):71–76
Dawson DW, Volpert OV, Gillis P, Crawford SE, Xu H, Benedict W, Bouck NP (1999) Pigment epithelium-derived factor: a potent inhibitor of angiogenesis. Science 285(5425):245–248
Friedman DS, O’Colmain BJ, Munoz B, Tomany SC, McCarty C, de Jong PT, Nemesure B, Mitchell P, Kempen J (2004a) Prevalence of age-related macular degeneration in the United States. Arch Ophthalmol 122(4):564–572. doi:10.1001/archopht.122.4.564
Friedman DS, O’Colmain BJ, Munoz B, Tomany SC, McCarty C, de Jong PT, Nemesure B, Mitchell P, Kempen J, Eye Diseases Prevalence Research G (2004b) Prevalence of age-related macular degeneration in the United States. Arch Ophthalmol 122(4):564–572. doi:10.1001/archopht.122.4.564
Gorin MB (2012) Genetic insights into age-related macular degeneration: controversies addressing risk, causality, and therapeutics. Mol Aspects Med 33(4):467–486. http://dx.doi.org/10.1016/j.mam.2012.04.004
Hageman GS, Anderson DH, Johnson LV, Hancox LS, Taiber AJ, Hardisty LI, Hageman JL, Stockman HA, Borchardt JD, Gehrs KM, Smith RJ, Silvestri G, Russell SR, Klaver CC, Barbazetto I, Chang S, Yannuzzi LA, Barile GR, Merriam JC, Smith RT, Olsh AK, Bergeron J, Zernant J, Merriam JE, Gold B, Dean M, Allikmets R (2005) A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci U S A 102(20):7227–7232. doi:10.1073/pnas.0501536102
Kaiser PK (2006) Antivascular endothelial growth factor agents and their development: therapeutic implications in ocular diseases. Am J Ophthalmol 142(4):660–668. doi:10.1016/j.ajo.2006.05.061
Kwak N, Okamoto N, Wood JM, Campochiaro PA (2000) VEGF is major stimulator in model of choroidal neovascularization. Invest Ophthalmol Vis Sci 41(10):3158–3164
Marx J (2006) Genetics – a clearer view of macular degeneration. Science 311(5768):1704–1705. doi:10.1126/science.311.5768.1704
Mitchell P, Smith W, Attebo K, Wang JJ (1995) Prevalence of age-related maculopathy in Australia. The Blue Mountains Eye Study. Ophthalmology 102(10):1450–1460
Mousa SA, Mousa SS (2010) Current status of vascular endothelial growth factor inhibition in age-related macular degeneration. BioDrugs 24(3):183–194. doi:10.2165/11318550-000000000-00000
Ratnapriya R, Chew EY (2013) Age-related macular degeneration-clinical review and genetics update. Clin Genet 84(2):160–166. doi:10.1111/cge.12206
Raychaudhuri S, Iartchouk O, Chin K, Tan PL, Tai AK, Ripke S, Gowrisankar S, Vemuri S, Montgomery K, Yu Y, Reynolds R, Zack DJ, Campochiaro B, Campochiaro P, Katsanis N, Daly MJ, Seddon JM (2011) A rare penetrant mutation in CFH confers high risk of age-related macular degeneration. Nat Genet 43(12):1232–U1291. doi:10.1038/Ng.976
Shen JK, Dong A, Hackett SF, Bell WR, Green WR, Campochiaro PA (2007) Oxidative damage in age-related macular degeneration. Histol Histopathol 22(12):1301–1308
Steinbrook R (2006) The price of sight–ranibizumab, bevacizumab, and the treatment of macular degeneration. N Engl J Med 355(14):1409–1412. doi:10.1056/NEJMp068185
Stellmach V, Crawford SE, Zhou W, Bouck N (2001) Prevention of ischemia-induced retinopathy by the natural ocular antiangiogenic agent pigment epithelium-derived factor. Proc Natl Acad Sci U S A 98(5):2593–2597. doi:10.1073/pnas.031252398
Zarbin MA (2004) Current concepts in the pathogenesis of age-related macular degeneration. Arch Ophthalmol 122(4):598–614
Zhou J, Jang YP, Kim SR, Sparrow JR (2006) Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium. Proc Natl Acad Sci U S A 103(44):16182–16187
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E.P. Rakoczy, C.C. Ronquillo, S.F. Passi, B.K. Ambati, Aaron Nagiel, Robert Lanza, and Steven D. Schwartz declare that they have no conflict of interest.
No human or animal studies were carried out for this chapter.
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Rakoczy, E.P. et al. (2015). Age-Related Macular Degeneration: The Challenges. In: Rakoczy, E. (eds) Gene- and Cell-Based Treatment Strategies for the Eye. Essentials in Ophthalmology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45188-5_5
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DOI: https://doi.org/10.1007/978-3-662-45188-5_5
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