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Gene Therapy and Stem Cell Therapy: Overview

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Gene- and Cell-Based Treatment Strategies for the Eye

Part of the book series: Essentials in Ophthalmology ((ESSENTIALS))

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Abstract

Here we have aimed to introduce the scientific concepts that led to the development of the fields of gene therapy and cell therapy. From the myriad of scientific discoveries that contributed, we have endeavored to crystallize the steps that were the most important and presented them in the context of scientific history. The birth of genetics led to the discovery of DNA, understanding of inheritance, variations, and mutations. However, not until the development of recombinant technologies that led to the generation of recombinant viruses was it possible to treat genetically inherited diseases. Cell therapies are also a new way of treating disease and here we provide an overview of the development of the field.

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Compliance with Ethical Requirements

Elizabeth Rakoczy, Samuel McLenachan, and Aaron Magno declare that they have no conflict of interest.

No animal or human studies were carried out by the authors of this chapter.

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Authors and Affiliations

  1. Department of Molecular Ophthalmology, Lions Eye Institute, Perth, WA, Australia

    Aaron L. Magno PhD

  2. Department of Ocular Tissue Engineering, Lions Eye Institute, Nedlands, WA, Australia

    Samuel McLenachan BSc(Hons), PhD

  3. Department of Molecular Ophthalmology, Centre for Ophthalmology and Visual Sciences, The University of Western Australia, Crawley, WA, Australia

    Elizabeth P. Rakoczy PhD

Authors
  1. Aaron L. Magno PhD
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  2. Samuel McLenachan BSc(Hons), PhD
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  3. Elizabeth P. Rakoczy PhD
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Corresponding author

Correspondence to Elizabeth P. Rakoczy PhD .

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Editors and Affiliations

  1. Department of Molecular Ophthalmology, Centre for Ophthalmology and Visual Sciences, The University of Western Australia, Crawley, West Australia, Australia

    Elizabeth P. Rakoczy

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Magno, A.L., McLenachan, S., Rakoczy, E.P. (2015). Gene Therapy and Stem Cell Therapy: Overview. In: Rakoczy, E. (eds) Gene- and Cell-Based Treatment Strategies for the Eye. Essentials in Ophthalmology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45188-5_1

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  • DOI: https://doi.org/10.1007/978-3-662-45188-5_1

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-45187-8

  • Online ISBN: 978-3-662-45188-5

  • eBook Packages: MedicineMedicine (R0)

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