Basal Cell Carcinoma
Basal cell carcinoma (BCC), 80 % of all nonmelanoma skin cancers (NMSCs), is the most common malignancy in humans, with an increasing incidence. Sun exposure, genetic predisposition, and immunosuppression are the main risk factors. Metastases are extremely rare and morbidity rather than mortality is the main issue regarding the socioeconomic impact of BCC. Surgical excision remains the treatment of choice in most cases, with radiotherapy still being a reliable alternative in selected cases. A variety of nonsurgical destructive methods such as cryotherapy, photodynamic treatment, and electrodessication after curettage, along with topical treatments such as imiquimod, are reserved for the treatment of superficial BCCs or basal cell nevus syndrome (BCNS). Recently, novel targeted systemic therapies inhibiting the sonic hedgehog pathway promise to revolutionize the treatment of advanced BCCs, metastasized or locally destructive and inoperable.
KeywordsBasal cell carcinoma Nonmelanoma skin cancer Mohs surgery Hedgehog inhibitors Cryotherapy Photodynamic therapy Imiquimod Radiotherapy Vismodegib
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