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Pityriasis Rubra Pilaris

  • Andrej PetrovEmail author
  • Vesna Pljakoska
Chapter

Abstract

Pityriasis rubra pilaris (PRP) is a chronic, inflammatory, papulosquamous disorder of keratinization of unknown etiology. It appears both in hereditary and in acquired form. According to the classification by Griffiths, there are six types of PRP: classical adult (type I), atypical adult (type II), classical juvenile (type III), circumscribed juvenile (type IV), and atypical juvenile (type V). Also, HIV-associated type VI has been described. Typical lesion is follicular hyperkeratotic papule. Spearing “islands” of not affected skin are a pathognomonic sign. Palms and soles are almost always involved, often showing an orange color, with palmoplantar waxy keratoderma. Histology is not confirmatory. PRP should be distinguished from psoriasis and other papulosquamous skin disorders. Treatment is topical or systemic. Retinoids are first-line treatment. Biologics are a new class of available medications for the off-label treatment of PRP, basically used with success in psoriasis.

Keywords

PRP Disorder Types Keratinization Keratoderma Treatment 

Reference

  1. Albert RM, Mackool BT. Review: pityriasis rubra pilaris. Int J Dermatol. 1999;38:1–11.CrossRefGoogle Scholar

Further Reading

  1. Ancevski, Gocev, Pavlova, Petrova. Dermatovenerologija. Kultura, Skopje, I Edition, 2005.Google Scholar
  2. Katsambas A., Lotti T. European handbook of dermatological treatments. 2nd ed. Springer; 2003.Google Scholar
  3. Pearce DJ, Feldman SR. Update on Infliximab: an intravenous biologic therapy for psoriasis. Expert Rev Dermatol. 2007;2(6):707–13.CrossRefGoogle Scholar
  4. Pincus DJ. Pityriasis rubra pilaris: a clinical review. Dermatol Nurs. 2005;17(6):448–51.PubMedGoogle Scholar
  5. Smith CH, et al. Biologic interventions in psoriasis. Br J Dermatol. 2009;161:987–1019.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Clinical Hospital AcibademsistinaSkopjeMacedonia

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