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Lymphogranuloma Venereum

  • Henry John Christiaan de VriesEmail author

Abstract

Lymphogranuloma venereum (LGV) has been renamed several times in the past and was known as tropical bubo, climatic bubo, poradenitis inguinalis, Durand-Nicolas-Favre disease, lymphopathia venereum and the fourth, fifth or sixth diseases. The causative agent of LGV is Chlamydia trachomatis genovar L. Worldwide, LGV is thought to account for 2–10 % of genito-ulcerative diseases in tropical climate areassuch as India and Africa. In Europe, North America and Australia, LGV is endemic mainly among HIV coinfected men who have sex with men. The first choice of treatment is an uninterrupted 21-day course of doxycycline 100 mg b.i.d.

Abbreviations

B.i.d.

Bis in die/two times a day

C

Chlamydia

LGV

Lymphogranuloma venereum

MSM

Men who have sex with men

NAAT

Nucleic acid amplification test

Q.i.d.

Quater in die/four times a day

STI

Sexually transmitted infection

References

  1. Banor Jr L, et al. Erythromycin treatment of lymphogranuloma venereum. In: Welch H et al., editors. Antibiotics annual 1953-54. New York: Medical Encyclopedia; 1953. p. 475–9.Google Scholar
  2. Centers for Disease Control and Prevention (CDC). Lymphogranuloma venereum among men who have sex with me--etherlands, 2003–2004. MMWR Morb Mortal Wkly Rep. 2004;53(42):985–8.Google Scholar
  3. Clinical Effectiveness Group of the British Association for Sexual Health and HIV (CEG/BASHH). 2006 National guideline for the management of lymphogranuloma venereum (LGV) of the British Association of Sexual Health and HIV (BASHH). 2006. http://www.bashh.org/documents/92/92.pdf.
  4. de Vries HJ, Reddy BS, Khandpur S. Chapter 41. Lymphogranuloma venereum. In: Gupta S, Kumar B, editors. Sexually transmitted infections. 2nd ed. New Delhi: Elsevier; 2012. p. 506–21.Google Scholar
  5. de Vries HJ, Zingoni A, White JA, Ross JD, Kreuter A. 2013 European Guideline on the management of proctitis, proctocolitis and enteritis caused by sexually transmissible pathogens. Int J STD AIDS. 2013;18;25(7):465–474.Google Scholar
  6. Guidelines for the management of sexually transmitted infections, WHO 2003. Downloadable from: http://apps.who.int/iris/bitstream/10665/42782/1/9241546263_eng.pdf. Accessed 26 June 2013.
  7. Rodríguez-Domínguez M, Puerta T, Menéndez B, González-Alba JM, Rodríguez C, Hellín T, Vera M, González-Sainz FJ, Clavo P, Villa M, Cantón R, Del Romero J, Galán JC. Clinical and epidemiological characterization of a lymphogranuloma venereum outbreak in Madrid, Spain: co-circulation of two variants. Clin Microbiol Infect. 2014;20(3):219–25.CrossRefGoogle Scholar
  8. Rönn MM, Ward H. The association between lymphogranuloma venereum and HIV among men who have sex with men: systematic review and meta-analysis. BMC Infect Dis. 2011;11:70.CrossRefGoogle Scholar
  9. Workowski KA, Berman S, Centers for Disease Control and Prevention (CDC). Sexually transmitted diseases treatment guidelines, 2010. MMWR Recomm Rep. 2010;59(RR-12):1–110.PubMedGoogle Scholar

Further Reading

  1. Davis TW, Goldstone SE. Sexually transmitted infections as a cause of proctitis in men who have sex with men. Dis Colon Rectum. 2009;52:507–12.Google Scholar
  2. de Vries HJ, Van der Bij AK, Fennema JS, et al. Lymphogranuloma venereum proctitis in men who have sex with men is associated with anal enema use and high-risk behavior. Sex Transm Dis. 2008;35(2):203–8.CrossRefGoogle Scholar
  3. de Vries HJ, Smelov V, Middelburg JG, Pleijster J, Speksnijder AG, Morré SA. Delayed microbial cure of lymphogranuloma venereum proctitis with doxycycline treatment. Clin Infect Dis. 2009;48(5):e53–6.CrossRefGoogle Scholar
  4. de Vries HJ. Sexually transmitted infections in men who have sex with men. Clin Dermatol. 2014;32(2):181–8.Google Scholar
  5. de Vries HJ, Zingoni A, Kreuter A, Moi H, White JA. 2013 European guideline on the management of lymphogranuloma venereum. J Eur Acad Dermatol Venereol. 2014 doi:  10.1111/jdv.12461. [Epub ahead of print].
  6. de Vrieze NH, de Vries HJ. Lymphogranuloma venereum among men who have sex with men. An epidemiological and clinical review. Expert Rev Anti Infect Ther. 2014 Jun;12(6):697–704.Google Scholar
  7. de Vrieze NH, van Rooijen M, Speksnijder AG, de Vries HJ. Urethral lymphogranuloma venereum infections in men with anorectal lymphogranuloma venereum and their partners: the missing link in the current epidemic? Sex Transm Dis. 2013;40(8):607–8.CrossRefGoogle Scholar
  8. Hathorn E, et al. What is the appropriate treatment for the management of rectal Chlamydia trachomatis in men and women? Sex Transm Infect. 2012;88:352–4.CrossRefGoogle Scholar
  9. Hill SC, Hodson L, Smith A. An audit on the management of lymphogranuloma venereum in a sexual health clinic in London, UK. Int J STD AIDS. 2010;21(11):772–6.CrossRefGoogle Scholar
  10. Korhonen S, Hiltunen-Back E, Puolakkainen M. Genotyping of Chlamydia trachomatis in rectal and pharyngeal specimens: identification of LGV genotypes in Finland. Sex Transm Infect. 2012;88(6):465–9.CrossRefGoogle Scholar
  11. Luk NM. Lymphogranuloma venereum. In: Kuen-kong LO, et al., editors. Social hygiene handbook, handbook of dermatology and venereology. Lisbon Social Hygiene Service, Department of Health; 1996. p. 1–14.Google Scholar
  12. Martin DH, et al. A controlled trial of single dose of azithromycin for the treatment of chlamydial urethritis and cervicitis. The Azithromycin for Chlamydial infections study group. N Engl J Med. 1992;327:921–95.CrossRefGoogle Scholar
  13. McLean CA, Stoner BP, Workowski KA. Treatment of lymphogranuloma venereum. Clin Infect Dis. 2007;44 Suppl 3:S147–52.CrossRefGoogle Scholar
  14. Najafi JA, et al. Surgical aspects of inguinal lymphogranuloma venereum. Mil Med. 1979;144:697–9.CrossRefGoogle Scholar
  15. Peuchant O, Baldit C, Le Roy C, Trombert-Paolantoni S, Clerc M, Bébéar C, de Barbeyrac B. First case of Chlamydia trachomatis L2b proctitis in a woman. Clin Microbiol Infect. 2011;17(12):E21–3.CrossRefGoogle Scholar
  16. Pinsk I, Saloojee N, Friedlich M. Lymphogranuloma venereum as a cause of rectal stricture. Can J Surg. 2007;50(6):E31–2.PubMedPubMedCentralGoogle Scholar
  17. Prakash S, et al. Problematic ulcerative lesions in sexually transmitted diseases: surgical management. Sex Transm Dis. 1986;13:127–30.CrossRefGoogle Scholar
  18. Soni S, Srirajaskanthan R, Lucas SB, Alexander S, Wong T, White JA. Lymphogranuloma venereum proctitis masquerading as inflammatory bowel disease in 12 homosexual men. Aliment Pharmacol Ther. 2010;32(1):59–65.CrossRefGoogle Scholar
  19. Sowmini CN, et al. Minocycline in the treatment of lymphogranuloma venereum. J Am Vener Dis Assoc. 1976;2:19–22.PubMedGoogle Scholar
  20. Spaargaren J, Fennema HS, Morré SA, de Vries HJ, Coutinho RA. New lymphogranuloma venereum Chlamydia trachomatis variant, Amsterdam. Emerg Infect Dis. 2005;11(7):1090–2.CrossRefGoogle Scholar
  21. Vall-Mayans M, Caballero E, Sanz B. The emergence of lymphogranuloma venereum in Europe. Lancet. 2009;374(9686):356.CrossRefGoogle Scholar
  22. van der Bij AK, Spaargaren J, Morre SA, Fennema HS, Mindel A, Coutinho RA, de Vries HJ. Diagnostic and clinical implications of anorectal lymphogranuloma venereum in men who have sex with men: a retrospective case-control study. Clin Infect Dis. 2006;42:186–94.CrossRefGoogle Scholar
  23. van der Ham R, de Vries HJ. Lymphogranuloma venereum, where do we stand? Clinical recommendations. Drugs Today (Barc). 2009;45 Suppl B:39–43.Google Scholar
  24. Verweij SP, Ouburg S, de Vries H, Morré SA, van Ginkel CJ, Bos H, Sebens FW. The first case record of a female patient with bubonic lymphogranuloma venereum (LGV), serovariant L2b. Sex Transm Infect. 2012;88(5):346–7.CrossRefGoogle Scholar
  25. Ward H, Martin I, Macdonald N, Alexander S, Simms I, Fenton K, French P, Dean G, Ison C. Lymphogranuloma venereum in the United Kingdom. Clin Infect Dis. 2007;44:26–32.CrossRefGoogle Scholar
  26. Wright LT, et al. The treatment of lymphogranuloma venereum with terramycin. Antibiot Chemother. 1951;1:193–7.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of DermatologyAcademic Medical Centre, University of AmsterdamAmsterdamThe Netherlands
  2. 2.STI Outpatient ClinicCluster for Infectious Diseases, Public Health Service of AmsterdamAmsterdamThe Netherlands

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