Dermatitis Herpetiformis

  • Ines Lakos Jukic
  • Branka MarinovićEmail author


Dermatitis herpetiformis (DH) is a chronic, subepidermal autoimmune bullous disease associated with gluten sensitivity, and thus it can be defined as a cutaneous manifestation of celiac disease (CD). It was originally described by Louis Adolphus Duhring in 1884. DH is multifactorial disease, with strong association with HLA-DQ2 and HLA-DQ8 antigens, influenced by environmental factors. The diagnosis is based on clinical findings, histopathology, immunofluorescence studies, and serology. The gold standard for diagnosis of DH is finding of granular deposits of IgA within tips of dermal papillae in direct immunofluorescence study. When diagnosis is confirmed, the treatment with gluten-free diet and dapsone is usually recommended. It is necessary to regularly monitor potential side effects of dapsone as well as clinical signs of frequently associated diseases.


Dermatitis herpetiformis Celiac disease Transglutaminase Gluten-free diet Dapsone 

Further Reading

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Dermatology and VenereologyUniversity Hospital Center Zagreb, University of Zagreb School of MedicineZagrebCroatia

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