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Abstract

Bowen’s disease (BD) is an intraepidermal squamous cell carcinoma (SCC) with a tendency for progressive growth and low invasive risk, characterized by slowly growing, erythematous plaque with an irregular border, surface scaling and crusting. The risk of progression to invasive SCC is 3–5 % for extragenital lesions and 10 % for genital lesions. BD is very common in the Caucasian population with an incidence of 14 per 100,000 in some populations. The peak age group for BD is the seventh decade. The ratio of Bowen’s disease is approximately equal between males and females. BD is more commonly found on the head and neck of men and on the lower limbs and cheeks of women. BD is usually a solitary lesion, but in 10–20 % of patients, it occurs at multiple sites.

Abbreviations

5-FU

5-Fluorouracil

ALA

5-Aminolevulinic acid

BD

Bowen’s disease

HPV

Human papillomavirus

MAL

Methyl aminolevulinate

PDT

Photodynamic therapy

SCC

Squamous cell carcinoma

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Dermatovenerology, Dermatooncology UnitUniversity Hospital Centre “Sestre Milosrdnice”ZagrebCroatia
  2. 2.Referral Centre for Melanoma of the Ministry of Health of the Republic of CroatiaZagrebCroatia
  3. 3.School of Dental MedicineUniversity of ZagrebZagrebCroatia
  4. 4.President of the Croatian Dermatovenereological Society of the Croatian Medical AssociationZagrebCroatia

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