Skip to main content

Alopezien

  • Chapter
  • First Online:
  • 4121 Accesses

Part of the book series: Springer Reference Medizin ((SRM))

Zusammenfassung

Die Beurteilung von Kopfhautbiopsien mit der Fragestellung Alopezie wird von vielen Befundern als problematisch empfunden. Die Erkrankungen, die zum Haarverlust führen, zeigen oft überlappende Veränderungen; nicht zu vergessen ist die Dynamik des Krankheitsprozesses, die je nach Zeitpunkt zu unterschiedlichen histologischen Bildern führen kann. Sind dann die diagnostischen Hinweise sehr diskret und ist man mit den architektonischen Merkmalen der Haarfollikeln im Horizontalschnitt wenig vertraut, wird es schwierig eine Diagnose zu stellen. Das ist vor allem bei den nicht-vernarbenden Alopezien der Fall. Hier stehen eher quantitative und weniger qualitative Veränderungen im Vordergrund. Wie bei allen entzündlichen Prozessen ist es wichtig, das histologische Bild klinisch zu korrelieren. Eine gute klinisch-pathologische Korrelation erspart ein mühsames Zählen von Anagen- und Telogenfollikeln. Im Idealfall liegen zwei 4 mm Stanzbiopsien vor, die reichlich Subkutis enthalten.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   589.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD   599.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Literatur

  • Aaronson CM (1969) Etiologic factors in traction alopecia. South Med J 62:185–186

    Article  CAS  PubMed  Google Scholar 

  • Annessi G, Lombardo G, Gobello T et al (1999) A clinicopathologic study of scarring alopecia due to lichen planus: comparison with scarring alopecia in discoid lupus erythematosus and pseudopelade. Am J Dermatopathol 21:324–331

    Article  CAS  PubMed  Google Scholar 

  • Aslani FS, Dastgheib L, Banihashemi BM (2009) Hair counts in scalp biopsy of males and females with androgenetic alopecia compared with normal subjects. J Cutan Pathol 36:734–739

    Article  PubMed  Google Scholar 

  • Bahta AW, Farjo N, Farjo B et al (2008) Premature senescence of balding dermal papilla cells in vitro is associated with p16(INK4a) expression. J Invest Dermatol 128:1088–1094

    Article  CAS  PubMed  Google Scholar 

  • Bergfeld W, Mulinari-Brenner F, McCarron K et al (2002) The combined utilization of clinical and histological findings in the diagnosis of trichotillomania. J Cutan Pathol 29:207–214

    Article  PubMed  Google Scholar 

  • Boyer JD, Vidmar DA (1994) Postoperative alopecia: a case report and literature review. Cutis 54:321–322

    CAS  PubMed  Google Scholar 

  • Caputo R, Veraldi S (1993) Erosive pustular dermatosis of the scalp. J Am Acad Dermatol 28:96–98

    Article  CAS  PubMed  Google Scholar 

  • Davies KE, Yesudian P (2012) Pressure alopecia. Int J Trichol 4:64–68

    Article  Google Scholar 

  • Dinehart SM, Herzberg AJ, Kerns BJ et al (1989) Acne keloidalis: a review. J Dermatol Surg Oncol 15:642–647

    Article  CAS  PubMed  Google Scholar 

  • Donati A, Molina L, Doche I et al (2011) Facial papules in frontal fibrosing alopecia: evidence of vellus follicle involvement. Arch Dermatol 147:1424–1427

    Article  PubMed  Google Scholar 

  • El Shabrawi-Caelen L, La Placa M, Vincenzi C et al (2010) Adalimumab-induced psoriasis of the scalp with diffuse alopecia: a severe potentially irreversible cutaneous side effect of TNF-alpha blockers. Inflamm Bowel Dis 16:182–183

    Article  PubMed  Google Scholar 

  • Eudy G, Solomon AR (2006) The histopathology of noncicatricial alopecia. Semin Cutan Med Surg 25:35–40

    Article  CAS  PubMed  Google Scholar 

  • Frieden IJ (1986) Aplasia cutis congenita: a clinical review and proposal for classification. J Am Acad Dermatol 14:646–660

    Article  CAS  PubMed  Google Scholar 

  • Gilhar A (2010) Collapse of immune privilege in alopecia areata: coincidental or substantial? J Invest Dermatol 130:2535–2537

    Article  CAS  PubMed  Google Scholar 

  • Hamm H, Traupe H (1989) Loose anagen hair of childhood: the phenomenon of easily pluckable hair. J Am Acad Dermatol 20:242–248

    Article  CAS  PubMed  Google Scholar 

  • Harries MJ, Meyer K, Chaudhry I et al (2013) Lichen planopilaris is characterized by immune privilege collapse of the hair follicle’s epithelial stem cell niche. J Pathol 231:236–247

    Article  CAS  PubMed  Google Scholar 

  • Headington JT (1993) Telogen effluvium. New concepts and review. Arch Dermatol 129:356–363

    Article  CAS  PubMed  Google Scholar 

  • Headington JT (1984) Transverse microscopic anatomy of the human scalp. A basis for a morphometric approach to disorders of the hair follicle. Arch Dermatol 120:449–456

    Article  CAS  PubMed  Google Scholar 

  • Hordinsky M, Kavand S, Kennedy W et al (2013) Small fiber neuropathy in symptomatic lichen planopilaris and frontal fibrosing alopecia. J Invest Dermatol 133:1403

    Google Scholar 

  • Karnik P, Tekeste Z, McCormick TS et al (2009) Hair follicle stem cell-specific PPARgamma deletion causes scarring alopecia. J Invest Dermatol 129:1243–1257

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Khumalo NP, Jessop S, Gumedze F et al (2007) Hairdressing and the prevalence of scalp disease in African adults. Br J Dermatol 157:981–988

    Article  CAS  PubMed  Google Scholar 

  • Kossard S, Collins A, McCrossin I (1987) Necrotizing lymphocytic folliculitis: the early lesion of acne necrotica (varioliformis). J Am Acad Dermatol 16:1007–1014

    Article  CAS  PubMed  Google Scholar 

  • Kossard S (1994) Postmenopausal frontal fibrosing alopecia. Scarring alopecia in a pattern distribution. Arch Dermatol 130:770–774

    Article  CAS  PubMed  Google Scholar 

  • LoPresti P, Papa CM, Kligman AM (1968) Hot comb alopecia. Arch Dermatol 98:234–238

    Article  CAS  PubMed  Google Scholar 

  • Milde P, Goerz G, Plewig G (1993) Acne necrotica (varioliformis). Necrotizing lymphocytic folliculitis. Hautarzt 44:34–36

    CAS  PubMed  Google Scholar 

  • Miteva M, Misciali C, Fanti PA et al (2011) Permanent alopecia after systemic chemotherapy: a clinicopathological study of 10 cases. Am J Dermatopathol 33:345–350

    Article  PubMed  Google Scholar 

  • Miteva M, Torres F, Tosti A (2012) The ‚eyes‘ or ‚goggles‘ as a clue to the histopathological diagnosis of primary lymphocytic cicatricial alopecia. Br J Dermatol 166:454–455

    Article  CAS  PubMed  Google Scholar 

  • Miteva M, Tosti A (2012) ‚A detective look‘ at hair biopsies from African-American patients. Br J Dermatol 166:1289–1294

    Article  CAS  PubMed  Google Scholar 

  • Moyer DG, Williams RM (1962) Perifolliculitis capitis abscedens et suffodiens. A report of six cases. Arch Dermatol 85:378–384

    Article  CAS  PubMed  Google Scholar 

  • Muller CS, El Shabrawi-Caelen L (2011) ‚Follicular Swiss cheese‘ pattern – another histopathologic clue to alopecia areata. J Cutan Pathol 38:185–189

    Article  PubMed  Google Scholar 

  • Muller SA (1990) Trichotillomania: a histopathologic study in sixty-six patients. J Am Acad Dermatol 23:56–62

    Article  CAS  PubMed  Google Scholar 

  • Powell JJ, Dawber RP, Gatter K (1999) Folliculitis decalvans including tufted folliculitis: clinical, histological and therapeutic findings. Br J Dermatol 140:328–333

    Article  CAS  PubMed  Google Scholar 

  • Prevezas C, Matard B, Pinquier L et al (2009) Irreversible and severe alopecia following docetaxel or paclitaxel cytotoxic therapy for breast cancer. Br J Dermatol 160:883–885

    Article  CAS  PubMed  Google Scholar 

  • Rand R, Baden HP (1983) Keratosis follicularis spinulosa decalvans. Report of two cases and literature review. Arch Dermatol 119:22–26

    Article  CAS  PubMed  Google Scholar 

  • Ross EK, Tan E, Shapiro J (2005) Update on primary cicatricial alopecias. J Am Acad Dermatol 53:1–37, quiz 8–40

    Article  PubMed  Google Scholar 

  • Silvers DN, Katz BE, Young AW (1993) Pseudopelade of Brocq is lichen planopilaris: report of four cases that support this nosology. Cutis 51:99–105

    CAS  PubMed  Google Scholar 

  • Solomon AR (1994) The transversely sectioned scalp biopsy specimen: the technique and an algorithm for its use in the diagnosis of alopecia. Adv Dermatol 9:127–157, discussion 58

    CAS  PubMed  Google Scholar 

  • Sperling LC (2001) Scarring alopecia and the dermatopathologist. J Cutan Pathol 28:333–342

    Article  CAS  PubMed  Google Scholar 

  • Sperling LC, Cowper SE (2006) The histopathology of primary cicatricial alopecia. Semin Cutan Med Surg 25:41–50

    Article  CAS  PubMed  Google Scholar 

  • Sperling LC, Lupton GP (1995) Histopathology of non-scarring alopecia. J Cutan Pathol 22:97–114

    Article  CAS  PubMed  Google Scholar 

  • Sperling LC, Sau P (1992) The follicular degeneration syndrome in black patients. ‚Hot comb alopecia‘ revisited and revised. Arch Dermatol 128:68–74

    Article  CAS  PubMed  Google Scholar 

  • Sperling LC, Winton GB (1990) The transverse anatomy of androgenic alopecia. J Dermatol Surg Oncol 16:1127–1133

    Article  CAS  PubMed  Google Scholar 

  • Sperling LC, Homoky C, Pratt L et al (2000a) Acne keloidalis is a form of primary scarring alopecia. Arch Dermatol 136:479–484

    CAS  PubMed  Google Scholar 

  • Sperling LC, Solomon AR, Whiting DA (2000b) A new look at scarring alopecia. Arch Dermatol 136:235–242

    CAS  PubMed  Google Scholar 

  • Tosti A, Iorizzo M, Piraccini BM (2005) Androgenetic alopecia in children: report of 20 cases. Br J Dermatol 152:556–559

    Article  CAS  PubMed  Google Scholar 

  • Trakimas C, Sperling LC, Skelton HG 3rd et al (1994) Clinical and histologic findings in temporal triangular alopecia. J Am Acad Dermatol 31:205–209

    Article  CAS  PubMed  Google Scholar 

  • Vano-Galvan S, Molina-Ruiz AM, Serrano-Falcon C et al (2014) Frontal fibrosing alopecia: a multicenter review of 355 patients. J Am Acad Dermatol 70:670–678

    Article  PubMed  Google Scholar 

  • Whiting DA (1995) Histopathology of alopecia areata in horizontal sections of scalp biopsies. J Invest Dermatol 104:26S–27S

    Article  CAS  PubMed  Google Scholar 

  • Whiting DA (1998) Male pattern hair loss: current understanding. Int J Dermatol 37:561–566

    Article  CAS  PubMed  Google Scholar 

  • Yazdabadi A, Magee J, Harrison S et al (2008) The Ludwig pattern of androgenetic alopecia is due to a hierarchy of androgen sensitivity within follicular units that leads to selective miniaturization and a reduction in the number of terminal hairs per follicular unit. Br J Dermatol 159:1300–1302

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to L. El Shabrawi-Caelen .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

El Shabrawi-Caelen, L. (2016). Alopezien. In: Cerroni, L., Garbe, C., Metze, D., Kutzner, H., Kerl, H. (eds) Histopathologie der Haut. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45133-5_19

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-45133-5_19

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-45132-8

  • Online ISBN: 978-3-662-45133-5

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics