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Live-Attenuated and Inactivated Whole-Cell Bacterial Vaccines

  • Anita H. J. van den Biggelaar
  • Jan T. PoolmanEmail author
Chapter

Abstract

Pathogen attenuation to allow its safe administration to protect otherwise susceptible subjects from infection is one of the earliest principles of vaccinology. At the same time that the first live-attenuated vaccines were developed, immunization with killed bacteria was being explored. Thus, live-attenuated and inactivated whole-cell bacterial vaccines are the oldest human vaccines still in use today. Live-attenuated bacterial vaccines currently in use are Bacille Calmette-Guérin (BCG) vaccines that have demonstrated effectiveness in preventing disseminated childhood tuberculosis and that are still used to immunize newborns worldwide; and a typhoid vaccine that is used primarily as a traveler’s vaccine. Killed whole-cell bacterial vaccines still in use are Bordetella pertussis vaccines which continue to be administered to prevent whooping cough to the majority of the global birth cohort, particularly in low-income countries; and cholera vaccines which are used mainly by travelers to endemic areas, and to a lesser extent to control infections in endemic or epidemic settings. The production of live-attenuated and killed vaccines has been troubled historically by issues of quality and poor efficacy. Incomplete attenuation is associated with the risk of acute infection and disease by the vaccine strain. Production of inactivated vaccines of inconsistent potency and quality has led to outbreaks of disease in countries where vaccines of low potency have been used. Serological correlates of protection have not been identified. New approaches to prevent these bacterial diseases, including the development of live genetically attenuated vaccines are under development.

Keywords

Vaccine Strain Typhoid Fever Pertussis Vaccine Acellular Pertussis Vaccine Cholera Outbreak 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Aaby P, Benn CS (2012) Saving lives by training innate immunity with bacille Calmette-Guerin vaccine. Proc Natl Acad Sci USA 109(43):17317–17318. doi: 10.1073/pnas.1215761109 PubMedCentralPubMedGoogle Scholar
  2. Alam M, Sultana M, Nair GB, Siddique AK, Hasan NA, Sack RB, Sack DA, Ahmed KU, Sadique A, Watanabe H, Grim CJ, Huq A, Colwell RR (2007) Viable but nonculturable Vibrio cholerae O1 in biofilms in the aquatic environment and their role in cholera transmission. Proc Natl Acad Sci USA 104(45):17801–17806. doi: 10.1073/pnas.0705599104 PubMedCentralPubMedGoogle Scholar
  3. Alrabiaah AA, Alsubaie SS, Bukhari EI, Gad A, Alzamel FA (2012) Outbreak of bacille Calmette-Guerin-related lymphadenitis in Saudi children at a university hospital after a change in the strain of vaccine. Ann Saudi Med 32(1):4–8PubMedGoogle Scholar
  4. Aporta A, Arbues A, Aguilo JI, Monzon M, Badiola JJ, de Martino A, Ferrer N, Marinova D, Anel A, Martin C, Pardo J (2012) Attenuated Mycobacterium tuberculosis SO2 vaccine candidate is unable to induce cell death. PLoS ONE 7(9):e45213. doi: 10.1371/journal.pone.0045213 PubMedCentralPubMedGoogle Scholar
  5. Ausiello CM, Urbani F, la Sala A, Lande R, Cassone A (1997) Vaccine- and antigen-dependent type 1 and type 2 cytokine induction after primary vaccination of infants with whole-cell or acellular pertussis vaccines. Infect Immun 65(6):2168–2174PubMedCentralPubMedGoogle Scholar
  6. Benitez JA, Garcia L, Silva A, Garcia H, Fando R, Cedre B, Perez A, Campos J, Rodriguez BL, Perez JL, Valmaseda T, Perez O, Ramirez M, Ledon T, Jidy MD, Lastre M, Bravo L, Sierra G (1999) Preliminary assessment of the safety and immunogenicity of a new CTXPhi-negative, hemagglutinin/protease-defective El Tor strain as a cholera vaccine candidate. Infect Immun 67(2):539–545PubMedCentralPubMedGoogle Scholar
  7. Black RE, Levine MM, Clements ML, Losonsky GA, Herrington D, Berman S, Formal SB (1987) Prevention of shigellosis by a Salmonella typhi–Shigella sonnei bivalent vaccine. J Infect Dis 155(6):1260–1265Google Scholar
  8. Bordet J, Gengou U (1906) Le microbe de la coqueluche. Ann Inst Pasteur 20:48–68Google Scholar
  9. Burgess M, Forrest J (1996) Pertussis and the acellular vaccines. Commun Dis Intell 20:192–193Google Scholar
  10. Burl S, Adetifa UJ, Cox M, Touray E, Ota MO, Marchant A, Whittle H, McShane H, Rowland-Jones SL, Flanagan KL (2010) Delaying bacillus Calmette-Guerin vaccination from birth to 4 1/2 months of age reduces postvaccination Th1 and IL-17 responses but leads to comparable mycobacterial responses at 9 months of age. J Immunol 185(4):2620–2628. doi: 10.4049/jimmunol.1000552 PubMedGoogle Scholar
  11. Calain P, Chaine JP, Johnson E, Hawley ML, O’Leary MJ, Oshitani H, Chaignat CL (2004) Can oral cholera vaccination play a role in controlling a cholera outbreak? Vaccine 22(19):2444–2451PubMedGoogle Scholar
  12. Campbell H, Amirthalingam G, Andrews N, Fry NK, George RC, Harrison TG, Miller E (2012) Accelerating control of pertussis in England and Wales. Emerg Infect Dis 18(1):38–47. doi: 10.3201/eid1801.110784 PubMedCentralPubMedGoogle Scholar
  13. Canaday DH, Wilkinson RJ, Li Q, Harding CV, Silver RF, Boom WH (2001) CD4(+) and CD8(+) T cells kill intracellular Mycobacterium tuberculosis by a perforin and Fas/Fas ligand-independent mechanism. J Immunol 167(5):2734–2742PubMedGoogle Scholar
  14. Capinos Scherer CF, Endsley JJ, de Aguiar JB, Jacobs WR Jr, Larsen MH, Palmer MV, Nonnecke BJ, Ray Waters W, Mark Estes D (2009) Evaluation of granulysin and perforin as candidate biomarkers for protection following vaccination with Mycobacterium bovis BCG or M. bovisDeltaRD1. Transbound Emerg Dis 56(6–7):228–239. doi: 10.1111/j.1865-1682.2008.01058.x
  15. Cardona PJ, Asensio JG, Arbues A, Otal I, Lafoz C, Gil O, Caceres N, Ausina V, Gicquel B, Martin C (2009) Extended safety studies of the attenuated live tuberculosis vaccine SO2 based on phoP mutant. Vaccine 27(18):2499–2505. doi: 10.1016/j.vaccine.2009.02.060 PubMedGoogle Scholar
  16. Centers for Disease Control and Prevention (2002) Pertussis–United States, 1997–2000. MMWR Morb Mortal Wkly Rep 51(4):73–76Google Scholar
  17. Chackerian AA, Perera TV, Behar SM (2001) Gamma interferon-producing CD4+ T lymphocytes in the lung correlate with resistance to infection with Mycobacterium tuberculosis. Infect Immun 69(4):2666–2674. doi: 10.1128/IAI.69.4.2666-2674.2001 PubMedCentralPubMedGoogle Scholar
  18. Charles RC, Harris JB, Chase MR, Lebrun LM, Sheikh A, Larocque RC, Logvinenko T, Rollins SM, Tarique A, Hohmann EL, Rosenberg I, Krastins B, Sarracino DA, Qadri F, Calderwood SB, Ryan ET (2009) Comparative proteomic analysis of the PhoP regulon in Salmonella enterica serovar Typhi versus Typhimurium. PLoS ONE 4(9):e6994Google Scholar
  19. Cherry JD (1996) Historical review of pertussis and the classical vaccine. J Infect Dis 174(Suppl 3):S259–S263PubMedGoogle Scholar
  20. Chowdhury MI, Sheikh A, Qadri F (2009) Development of Peru-15 (CholeraGarde), a live-attenuated oral cholera vaccine: 1991–2009. Expert Rev Vaccines 8(12):1643–1652PubMedGoogle Scholar
  21. Clemens J, Shin S, Sur D, Nair GB, Holmgren J (2011) New-generation vaccines against cholera. Nat Rev Gastroenterol Hepatol 8(12):701–710PubMedGoogle Scholar
  22. Clemens JD, Harris JR, Sack DA, Chakraborty J, Ahmed F, Stanton BF, Khan MU, Kay BA, Huda N, Khan MR et al (1988) Field trial of oral cholera vaccines in Bangladesh: results of one year of follow-up. J Infect Dis 158(1):60–69PubMedGoogle Scholar
  23. Clemens JD, Sack DA, Harris JR, Van Loon F, Chakraborty J, Ahmed F, Rao MR, Khan MR, Yunus M, Huda N et al (1990) Field trial of oral cholera vaccines in Bangladesh: results from three-year follow-up. Lancet 335(8684):270–273PubMedGoogle Scholar
  24. Cooper AM, Dalton DK, Stewart TA, Griffin JP, Russell DG, Orme IM (1993) Disseminated tuberculosis in interferon gamma gene-disrupted mice. J Exp Med 178(6):2243–2247PubMedGoogle Scholar
  25. Corbel MJ (1996) Reasons for instability of bacterial vaccines. Dev Biol Stand 87:113–124PubMedGoogle Scholar
  26. Corbel MJ, Kreeftenberg JG, Knezevic I (2004) WHO Working Group on the standardisation and control of pertussis vaccines-report of a meeting held on 6–7 May 2003, Ferney Voltaire, France. Vaccine 22(3–4):293–300PubMedGoogle Scholar
  27. Corbel MJ, Xing DK (2004) Toxicity and potency evaluation of pertussis vaccines. Expert Rev Vaccines 3(1):89–101. doi: 10.1586/14760584.3.4.S89 PubMedGoogle Scholar
  28. Cornford-Nairns R, Daggard G, Mukkur T (2012) Construction and preliminary immunobiological characterization of a novel, non-reverting, intranasal live attenuated whooping cough vaccine candidate. J Microbiol Biotechnol 22(6):856–865PubMedGoogle Scholar
  29. Cortese MM, Baughman AL, Zhang R, Srivastava PU, Wallace GS (2008) Pertussis hospitalizations among infants in the United States, 1993 to 2004. Pediatrics 121(3):484–492. doi: 10.1542/peds.2007-1393 PubMedGoogle Scholar
  30. Coster TS, Killeen KP, Waldor MK, Beattie DT, Spriggs DR, Kenner JR, Trofa A, Sadoff JC, Mekalanos JJ, Taylor DN (1995) Safety, immunogenicity, and efficacy of live attenuated Vibrio cholerae O139 vaccine prototype. Lancet 345(8955):949–952PubMedGoogle Scholar
  31. Crowcroft NS, Booy R, Harrison T, Spicer L, Britto J, Mok Q, Heath P, Murdoch I, Zambon M, George R, Miller E (2003) Severe and unrecognised: pertussis in UK infants. Arch Dis Child 88(9):802–806PubMedCentralPubMedGoogle Scholar
  32. Crump JA, Luby SP, Mintz ED (2004) The global burden of typhoid fever. Bull World Health Organ 82(5):346–353PubMedCentralPubMedGoogle Scholar
  33. Davisson EO, Powell HM, Macfarlane JO, Hodgson R, Stone RL, Culbertson CG (1956) The preservation of poliomyelitis vaccine with stabilized merthiolate. J Lab Clin Med 47(1):8–19PubMedGoogle Scholar
  34. de Greeff SC, de Melker HE, Westerhof A, Schellekens JF, Mooi FR, van Boven M (2012) Estimation of household transmission rates of pertussis and the effect of cocooning vaccination strategies on infant pertussis. Epidemiology 23(6):852–860. doi: 10.1097/EDE.0b013e31826c2b9e PubMedGoogle Scholar
  35. de Melker HE, Conyn-van Spaendonck MA, Rumke HC, van Wijngaarden JK, Mooi FR, Schellekens JF (1997) Pertussis in the Netherlands: an outbreak despite high levels of immunization with whole-cell vaccine. Emerg Infect Dis 3(2):175–178. doi: 10.3201/eid0302.970211 PubMedCentralPubMedGoogle Scholar
  36. De Serres G, Shadmani R, Duval B, Boulianne N, Dery P, Douville Fradet M, Rochette L, Halperin SA (2000) Morbidity of pertussis in adolescents and adults. J Infect Dis 182(1):174–179. doi: 10.1086/315648 PubMedGoogle Scholar
  37. Denoel P, Godfroid F, Guiso N, Hallander H, Poolman J (2005) Comparison of acellular pertussis vaccines-induced immunity against infection due to Bordetella pertussis variant isolates in a mouse model. Vaccine 23(46–47):5333–5341. doi: 10.1016/j.vaccine.2005.06.021 PubMedGoogle Scholar
  38. Diel R, Goletti D, Ferrara G, Bothamley G, Cirillo D, Kampmann B, Lange C, Losi M, Markova R, Migliori GB, Nienhaus A, Ruhwald M, Wagner D, Zellweger JP, Huitric E, Sandgren A, Manissero D (2011) Interferon-gamma release assays for the diagnosis of latent Mycobacterium tuberculosis infection: a systematic review and meta-analysis. Eur Respir J 37(1):88–99. doi: 10.1183/09031936.00115110 PubMedGoogle Scholar
  39. Donoghue HD, Lee OY, Minnikin DE, Besra GS, Taylor JH, Spigelman M (2010) Tuberculosis in Dr Granville’s mummy: a molecular re-examination of the earliest known Egyptian mummy to be scientifically examined and given a medical diagnosis. Proc Biol Sci 277(1678):51–56. doi: 10.1098/rspb.2009.1484 PubMedCentralPubMedGoogle Scholar
  40. Edwards KM (2005) Overview of pertussis: focus on epidemiology, sources of infection, and long term protection after infant vaccination. Pediatr Infect Dis J 24(6 Suppl):S104–S108PubMedGoogle Scholar
  41. Edwards KM, Decker MD, Halsey NA, Koblin BA, Townsend T, Auerbach B, Karzon DT (1991) Differences in antibody response to whole-cell pertussis vaccines. Pediatrics 88(5):1019–1023PubMedGoogle Scholar
  42. Ernst WA, Thoma-Uszynski S, Teitelbaum R, Ko C, Hanson DA, Clayberger C, Krensky AM, Leippe M, Bloom BR, Ganz T, Modlin RL (2000) Granulysin, a T cell product, kills bacteria by altering membrane permeability. J Immunol 165(12):7102–7108PubMedGoogle Scholar
  43. Favre D, Struck MM, Cryz SJ Jr, Viret JF (1996) Further molecular characterization and stability of the live oral attenuated cholera vaccine strain CVD103-HgR. Vaccine 14(6):526–531PubMedGoogle Scholar
  44. Feunou PF, Bertout J, Locht C (2010a) T- and B-cell-mediated protection induced by novel, live attenuated pertussis vaccine in mice. Cross protection against parapertussis. PLoS ONE 5(4):e10178 doi: 10.1371/journal.pone.0010178
  45. Feunou PF, Kammoun H, Debrie AS, Mielcarek N, Locht C (2010b) Long-term immunity against pertussis induced by a single nasal administration of live attenuated B. pertussis BPZE1. Vaccine 28(43):7047–7053. doi: 10.1016/j.vaccine.2010.08.017
  46. Fine PE (1995) Variation in protection by BCG: implications of and for heterologous immunity. Lancet 346(8986):1339–1345PubMedGoogle Scholar
  47. Fine PE, Clarkson JA (1987) Reflections on the efficacy of pertussis vaccines. Rev Infect Dis 9(5):866–883PubMedGoogle Scholar
  48. Fine PE, Ponnighaus JM, Maine NP (1986) The relationship between delayed type hypersensitivity and protective immunity induced by mycobacterial vaccines in man. Lepr Rev 57(Suppl 2):275–283PubMedGoogle Scholar
  49. Fine PE, Sterne JA, Ponnighaus JM, Rees RJ (1994) Delayed-type hypersensitivity, mycobacterial vaccines and protective immunity. Lancet 344(8932):1245–1249PubMedGoogle Scholar
  50. Fleming PJ, Blair PS, Platt MW, Tripp J, Smith IJ, Golding J (2001) The UK accelerated immunisation programme and sudden unexpected death in infancy: case-control study. BMJ 322(7290):822PubMedCentralPubMedGoogle Scholar
  51. Formal SB, Baron LS, Kopecko DJ, Washington O, Powell C, Life CA (1981) Construction of a potential bivalent vaccine strain: introduction of Shigella sonnet form I antigen genes into the galE Salmonella typhi Ty21a typhoid vaccine strain. Infect Immun 34(3):746–750PubMedCentralPubMedGoogle Scholar
  52. Galazka A (1993) Pertussis. In The immunological basis for immunization. WHO/EPI/GEN/93.14:1–20Google Scholar
  53. Gale JL, Thapa PB, Wassilak SG, Bobo JK, Mendelman PM, Foy HM (1994) Risk of serious acute neurological illness after immunization with diphtheria-tetanus-pertussis vaccine. A population-based case-control study. JAMA 271(1):37–41PubMedGoogle Scholar
  54. Garcia HM, Thompson R, Valera R, Fando R, Fumane J, Jani I, Mirabal M, Armesto MI, Songane M, Luis S, Nzualo AM, Celeste J, Viegas S, Gudo ES, Melembe A, Bila D, Cema C, Mabumo C, Garcia L, Cedre B, Ano G, Martinez JC, Mandarioti A, Lugones J, Gonzalez D, Baro M, Hernandez J, Talavera A, Solis RL, Sierra G, Barbera R, Dominguez F, Gutierrez C, Campa C, Garrido I, Menendez J (2011) A single dose of live-attenuated 638 Vibrio cholerae oral vaccine is safe and immunogenic in adult volunteers in Mozambique. VacciMonitor 20(3):1–8Google Scholar
  55. Garcia L, Jidy MD, Garcia H, Rodriguez BL, Fernandez R, Ano G, Cedre B, Valmaseda T, Suzarte E, Ramirez M, Pino Y, Campos J, Menendez J, Valera R, Gonzalez D, Gonzalez I, Perez O, Serrano T, Lastre M, Miralles F, Del Campo J, Maestre JL, Perez JL, Talavera A, Perez A, Marrero K, Ledon T, Fando R (2005) The vaccine candidate Vibrio cholerae 638 is protective against cholera in healthy volunteers. Infect Immun 73(5):3018–3024PubMedCentralPubMedGoogle Scholar
  56. Garmory HS, Brown KA, Titball RW (2002) Salmonella vaccines for use in humans: present and future perspectives. FEMS Microbiol Rev 26(4):339–353PubMedGoogle Scholar
  57. Greco D, Salmaso S, Mastrantonio P, Giuliano M, Tozzi AE, Anemona A, Ciofi degli Atti ML, Giammanco A, Panei P, Blackwelder WC, Klein DL, Wassilak SG (1996) A controlled trial of two acellular vaccines and one whole-cell vaccine against pertussis. Progetto Pertosse Working Group. N Engl J Med 334(6):341–348. doi: 10.1056/NEJM199602083340601
  58. Griffin MR, Ray WA, Mortimer EA, Fenichel GM, Schaffner W (1990) Risk of seizures and encephalopathy after immunization with the diphtheria-tetanus-pertussis vaccine. JAMA 263(12):1641–1645PubMedGoogle Scholar
  59. Grimprel E, Begue P, Anjak I, Njamkepo E, Francois P, Guiso N (1996) Long-term human serum antibody responses after immunization with whole-cell pertussis vaccine in France. Clin Diagn Lab Immunol 3(1):93–97PubMedCentralPubMedGoogle Scholar
  60. Grode L, Seiler P, Baumann S, Hess J, Brinkmann V, Nasser Eddine A, Mann P, Goosmann C, Bandermann S, Smith D, Bancroft GJ, Reyrat JM, van Soolingen D, Raupach B, Kaufmann SH (2005) Increased vaccine efficacy against tuberculosis of recombinant Mycobacterium bovis bacille Calmette-Guerin mutants that secrete listeriolysin. J Clin Invest 115(9):2472–2479. doi: 10.1172/JCI24617 PubMedCentralPubMedGoogle Scholar
  61. Guiso N, Capiau C, Carletti G, Poolman J, Hauser P (1999) Intranasal murine model of Bordetella pertussis infection. I. Prediction of protection in human infants by acellular vaccines. Vaccine 17(19):2366–2376PubMedGoogle Scholar
  62. Gustafsson L, Hallander HO, Olin P, Reizenstein E, Storsaeter J (1996) A controlled trial of a two-component acellular, a five-component acellular, and a whole-cell pertussis vaccine. N Engl J Med 334(6):349–355. doi: 10.1056/NEJM199602083340602 PubMedGoogle Scholar
  63. Hallander H, Nilsson L, Gustafsson L (2011) Is adolescent pertussis vaccination preferable to natural booster infections? Expert reviews of clinical pharmacologyGoogle Scholar
  64. Harris JB, LaRocque RC, Qadri F, Ryan ET, Calderwood SB (2012) Cholera. Lancet 379(9835):2466–2476. doi: 10.1016/S0140-6736(12)60436-X PubMedCentralPubMedGoogle Scholar
  65. Health Council of the Netherlands (2004) Vaccination against pertussis (Vaccinatie tegen kinkhoest). The HagueGoogle Scholar
  66. Heininger U (2010) Update on pertussis in children. Expert Rev Anti Infect Ther 8(2):163–173PubMedGoogle Scholar
  67. Hindle Z, Chatfield SN, Phillimore J, Bentley ML, Johnson J (2002) Characterization of Salmonella enterica derivatives harboring defined aroC and Salmonella pathogenicity island 2 type III secretion system (ssaV) mutations by immunization of healthy volunteers. Vaccine 24:116–123Google Scholar
  68. Ho SY, Chua SQ, Foo DG, Locht C, Chow VT, Poh CL, Alonso S (2008) Highly attenuated Bordetella pertussis strain BPZE1 as a potential live vehicle for delivery of heterologous vaccine candidates. Infect Immun 76(1):111–119. doi: 10.1128/IAI.00795-07 PubMedCentralPubMedGoogle Scholar
  69. Hoffman HJ, Hunter JC, Damus K, Pakter J, Peterson DR, van Belle G, Hasselmeyer EG (1987) Diphtheria-tetanus-pertussis immunization and sudden infant death: results of the National Institute of Child Health and Human Development Cooperative Epidemiological Study of Sudden Infant Death Syndrome risk factors. Pediatrics 79(4):598–611PubMedGoogle Scholar
  70. Hoft DF, Blazevic A, Abate G, Hanekom WA, Kaplan G, Soler JH, Weichold F, Geiter L, Sadoff JC, Horwitz MA (2008) A new recombinant bacille Calmette-Guerin vaccine safely induces significantly enhanced tuberculosis-specific immunity in human volunteers. J Infect Dis 198(10):1491–1501. doi: 10.1086/592450 PubMedCentralPubMedGoogle Scholar
  71. Hohmann EL, Oletta CA, Killeen KP, Miller SI (1996) phoP/phoQ-deleted Salmonella typhi (Ty800) is a safe and immunogenic single-dose typhoid fever vaccine in volunteers. J Infect Dis 173(6):1408–1414PubMedGoogle Scholar
  72. Howson CP, Fineberg HV (1992) Adverse events following pertussis and rubella vaccines. Summary of a report of the Institute of Medicine. JAMA 267(3):392–396PubMedGoogle Scholar
  73. iDrugInfo.com (2000–2012) Pentacoq. In: Drugs information. http://www.idruginfo.com/drugs-p/pen/pentacoq.html
  74. Jain SK (2009) M-01ZH09, an oral live attenuated Salmonella enterica serovar Typhi vaccine for the prevention of typhoid fever. Curr Opin Mol Ther 11(5):565–571PubMedGoogle Scholar
  75. Jefferson T, Rudin M, DiPietrantonj C (2003) Systematic review of the effects of pertussis vaccines in children. Vaccine 21(17–18):2003–2014PubMedGoogle Scholar
  76. Kammoun H, Feunou PF, Foligne B, Debrie AS, Raze D, Mielcarek N, Locht C (2012) Dual mechanism of protection by live attenuated Bordetella pertussis BPZE1 against Bordetella bronchiseptica in mice. Vaccine 30(40):5864–5870. doi: 10.1016/j.vaccine.2012.07.005 PubMedGoogle Scholar
  77. Kleinnijenhuis J, Quintin J, Preijers F, Joosten LA, Ifrim DC, Saeed S, Jacobs C, van Loenhout J, de Jong D, Stunnenberg HG, Xavier RJ, van der Meer JW, van Crevel R, Netea MG (2012) Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes. Proc Natl Acad Sci USA 109(43):17537–17542. doi: 10.1073/pnas.1202870109 PubMedCentralPubMedGoogle Scholar
  78. Kopecko DJ, Sieber H, Ures JA, Furer A, Schlup J, Knof U, Collioud A, Xu D, Colburn K, Dietrich G (2009) Genetic stability of vaccine strain Salmonella typhi Ty21a over 25 years. Int J Med Microbiol 299(4):233–246PubMedGoogle Scholar
  79. Kupferschmidt K (2011) Infectious disease. Taking a new shot at a TB vaccine. Science 334(6062):1488–1490. doi: 10.1126/science.334.6062.1488
  80. Lacombe K, Yam A, Simondon K, Pinchinat S, Simondon F (2004) Risk factors for acellular and whole-cell pertussis vaccine failure in Senegalese children. Vaccine 23(5):623–628. doi: 10.1016/j.vaccine.2004.07.007 PubMedGoogle Scholar
  81. Lagos R, San Martin O, Wasserman SS, Prado V, Losonsky GA, Bustamante C, Levine MM (1999) Palatability, reactogenicity and immunogenicity of engineered live oral cholera vaccine CVD 103-HgR in Chilean infants and toddlers. Pediatr Infect Dis J 18(7):624–630PubMedGoogle Scholar
  82. Larsen MH, Biermann K, Chen B, Hsu T, Sambandamurthy VK, Lackner AA, Aye PP, Didier P, Huang D, Shao L, Wei H, Letvin NL, Frothingham R, Haynes BF, Chen ZW, Jacobs WR Jr (2009) Efficacy and safety of live attenuated persistent and rapidly cleared Mycobacterium tuberculosis vaccine candidates in non-human primates. Vaccine 27(34):4709–4717. doi: 10.1016/j.vaccine.2009.05.050 PubMedCentralPubMedGoogle Scholar
  83. Lee GM, Lett S, Schauer S, LeBaron C, Murphy TV, Rusinak D, Lieu TA, Massachusetts Pertussis Study G (2004) Societal costs and morbidity of pertussis in adolescents and adults. Clin Infect Dis 39(11):1572–1580. doi: 10.1086/425006
  84. Lee WI, Huang JL, Yeh KW, Jaing TH, Lin TY, Huang YC, Chiu CH (2011) Immune defects in active mycobacterial diseases in patients with primary immunodeficiency diseases (PIDs). J Formos Med Assoc 110(12):750–758. doi: 10.1016/j.jfma.2011.11.004 PubMedGoogle Scholar
  85. Levine MM, Ferreccio C, Abrego P, Martin OS, Ortiz E, Cryz S (1999) Duration of efficacy of Ty21a, attenuated Salmonella typhi live oral vaccine. Vaccine 17(Suppl 2):S22–S27PubMedGoogle Scholar
  86. Levine MM, Ferreccio C, Black RE, Lagos R, San Martin O, Blackwelder WC (2007) Ty21a live oral typhoid vaccine and prevention of paratyphoid fever caused by Salmonella enterica Serovar Paratyphi B. Clin Infect Dis 45(Suppl 1):S24–S28PubMedGoogle Scholar
  87. Levine MM, Kaper JB, Herrington D, Ketley J, Losonsky G, Tacket CO, Tall B, Cryz S (1988) Safety, immunogenicity, and efficacy of recombinant live oral cholera vaccines, CVD 103 and CVD 103-HgR. Lancet 2(8609):467–470PubMedGoogle Scholar
  88. Leyten EM, Prins C, Bossink AW, Thijsen S, Ottenhoff TH, van Dissel JT, Arend SM (2007) Effect of tuberculin skin testing on a Mycobacterium tuberculosis-specific interferon-gamma assay. Eur Respir J 29(6):1212–1216. doi: 10.1183/09031936.00117506 PubMedGoogle Scholar
  89. Liko J, Robinson SG, Cieslak PR (2013) Priming with whole-cell versus acellular pertussis vaccine. N Engl J Med 368(6):581–582Google Scholar
  90. Lin FY, Vo AH, Phan VB, Nguyen TT, Bryla D, Tran CT, Ha BK, Dang DT, Robbins JB (2000) The epidemiology of typhoid fever in the Dong Thap Province, Mekong Delta region of Vietnam. Am J Trop Med Hyg 62(5):644–648PubMedGoogle Scholar
  91. Liu D, Verma NK, Romana LK, Reeves PR (1991) Relationships among the rfb regions of Salmonella serovars A, B, and D. J Bacteriol 173:4814–4819Google Scholar
  92. Locht C, Antoine R, Raze D, Mielcarek N, Hot D, Lemoine Y, Mascart F (2004) Bordetella pertussis from functional genomics to intranasal vaccination. Int J Med Microbiol 293(7–8):583–588PubMedGoogle Scholar
  93. Locht C, Mielcarek N (2012) New pertussis vaccination approaches: en route to protect newborns? FEMS Immunol Med Microbiol 66(2):121–133. doi: 10.1111/j.1574-695X.2012.00988.x PubMedGoogle Scholar
  94. Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, Abraham J, Adair T, Aggarwal R, Ahn SY, Alvarado M, Anderson HR, Anderson LM, Andrews KG, Atkinson C, Baddour LM, Barker-Collo S, Bartels DH, Bell ML, Benjamin EJ, Bennett D, Bhalla K, Bikbov B, Bin Abdulhak A, Birbeck G, Blyth F, Bolliger I, Boufous S, Bucello C, Burch M, Burney P, Carapetis J, Chen H, Chou D, Chugh SS, Coffeng LE, Colan SD, Colquhoun S, Colson KE, Condon J, Connor MD, Cooper LT, Corriere M, Cortinovis M, de Vaccaro KC, Couser W, Cowie BC, Criqui MH, Cross M, Dabhadkar KC, Dahodwala N, De Leo D, Degenhardt L, Delossantos A, Denenberg J, Des Jarlais DC, Dharmaratne SD, Dorsey ER, Driscoll T, Duber H, Ebel B, Erwin PJ, Espindola P, Ezzati M, Feigin V, Flaxman AD, Forouzanfar MH, Fowkes FG, Franklin R, Fransen M, Freeman MK, Gabriel SE, Gakidou E, Gaspari F, Gillum RF, Gonzalez-Medina D, Halasa YA, Haring D, Harrison JE, Havmoeller R, Hay RJ, Hoen B, Hotez PJ, Hoy D, Jacobsen KH, James SL, Jasrasaria R, Jayaraman S, Johns N, Karthikeyan G, Kassebaum N, Keren A, Khoo JP, Knowlton LM, Kobusingye O, Koranteng A, Krishnamurthi R, Lipnick M, Lipshultz SE, Ohno SL, Mabweijano J, MacIntyre MF, Mallinger L, March L, Marks GB, Marks R, Matsumori A, Matzopoulos R, Mayosi BM, McAnulty JH, McDermott MM, McGrath J, Mensah GA, Merriman TR, Michaud C, Miller M, Miller TR, Mock C, Mocumbi AO, Mokdad AA, Moran A, Mulholland K, Nair MN, Naldi L, Narayan KM, Nasseri K, Norman P, O’Donnell M, Omer SB, Ortblad K, Osborne R, Ozgediz D, Pahari B, Pandian JD, Rivero AP, Padilla RP, Perez-Ruiz F, Perico N, Phillips D, Pierce K, Pope CA 3rd, Porrini E, Pourmalek F, Raju M, Ranganathan D, Rehm JT, Rein DB, Remuzzi G, Rivara FP, Roberts T, De Leon FR, Rosenfeld LC, Rushton L, Sacco RL, Salomon JA, Sampson U, Sanman E, Schwebel DC, Segui-Gomez M, Shepard DS, Singh D, Singleton J, Sliwa K, Smith E, Steer A, Taylor JA, Thomas B, Tleyjeh IM, Towbin JA, Truelsen T, Undurraga EA, Venketasubramanian N, Vijayakumar L, Vos T, Wagner GR, Wang M, Wang W, Watt K, Weinstock MA, Weintraub R, Wilkinson JD, Woolf AD, Wulf S, Yeh PH, Yip P, Zabetian A, Zheng ZJ, Lopez AD, Murray CJ (2012) Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380(9859):2095–2128PubMedGoogle Scholar
  95. Lugauer S, Heininger U, Cherry JD, Stehr K (2002) Long-term clinical effectiveness of an acellular pertussis component vaccine and a whole cell pertussis component vaccine. Eur J Pediatr 161(3):142–146PubMedGoogle Scholar
  96. Mahon BP, Brady MT, Mills KH (2000) Protection against Bordetella pertussis in mice in the absence of detectable circulating antibody: implications for long-term immunity in children. J Infect Dis 181(6):2087–2091. doi: 10.1086/315527 PubMedGoogle Scholar
  97. Marchant A, Goldman M (2005) T cell-mediated immune responses in human newborns: ready to learn? Clin Exp Immunol 141(1):10–18. doi: 10.1111/j.1365-2249.2005.02799.x PubMedCentralPubMedGoogle Scholar
  98. Martin C, Williams A, Hernandez-Pando R, Cardona PJ, Gormley E, Bordat Y, Soto CY, Clark SO, Hatch GJ, Aguilar D, Ausina V, Gicquel B (2006) The live Mycobacterium tuberculosis phoP mutant strain is more attenuated than BCG and confers protective immunity against tuberculosis in mice and guinea pigs. Vaccine 24(17):3408–3419. doi: 10.1016/j.vaccine.2006.03.017 PubMedGoogle Scholar
  99. Mielcarek N, Debrie AS, Mahieux S, Locht C (2010) Dose response of attenuated Bordetella pertussis BPZE1-induced protection in mice. Clin Vaccine Immunol 17(3):317–324. doi: 10.1128/CVI.00322-09 PubMedCentralPubMedGoogle Scholar
  100. Mielcarek N, Debrie AS, Raze D, Bertout J, Rouanet C, Younes AB, Creusy C, Engle J, Goldman WE, Locht C (2006a) Live attenuated B. pertussis as a single-dose nasal vaccine against whooping cough. PLoS Pathog 2(7):e65. doi: 10.1371/journal.ppat.0020065
  101. Mielcarek N, Debrie AS, Raze D, Quatannens J, Engle J, Goldman WE, Locht C (2006b) Attenuated Bordetella pertussis: new live vaccines for intranasal immunisation. Vaccine 24(Suppl 2):S2-54–55Google Scholar
  102. Miller D, Madge N, Diamond J, Wadsworth J, Ross E (1993) Pertussis immunisation and serious acute neurological illnesses in children. BMJ 307(6913):1171–1176PubMedCentralPubMedGoogle Scholar
  103. Miller DL, Ross EM, Alderslade R, Bellman MH, Rawson NS (1981) Pertussis immunisation and serious acute neurological illness in children. Br Med J (Clin Res Ed) 282(6276):1595–1599Google Scholar
  104. Milstien JB, Gibson JJ (1990) Quality control of BCG vaccine by WHO: a review of factors that may influence vaccine effectiveness and safety. Bull World Health Org 68(1):93–108PubMedCentralPubMedGoogle Scholar
  105. Moore DL, Le Saux N, Scheifele D, Halperin SA (2004) Lack of evidence of encephalopathy related to pertussis vaccine: active surveillance by IMPACT, Canada, 1993–2002. Pediatr Infect Dis J 23(6):568–571PubMedGoogle Scholar
  106. Mueller H, Fae KC, Magdorf K, Ganoza CA, Wahn U, Guhlich U, Feiterna-Sperling C, Kaufmann SH (2011) Granulysin-expressing CD4+ T cells as candidate immune marker for tuberculosis during childhood and adolescence. PLoS ONE 6(12):e29367. doi: 10.1371/journal.pone.0029367 PubMedCentralPubMedGoogle Scholar
  107. Nair GB, Faruque SM, Bhuiyan NA, Kamruzzaman M, Siddique AK, Sack DA (2002) New variants of Vibrio cholerae O1 biotype El Tor with attributes of the classical biotype from hospitalized patients with acute diarrhea in Bangladesh. J Clin Microbiol 40(9):3296–3299PubMedCentralPubMedGoogle Scholar
  108. Nikaido H (2003) Molecular basis of bacterial outer membrane permeability revisited. Microbiol Mol Biol Rev 67:593–656Google Scholar
  109. Ohtake S, Martin R, Saxena A, Pham B, Chiueh G, Osorio M, Kopecko D, Xu D, Lechuga-Ballesteros D, Truong-Le V (2011) Room temperature stabilization of oral, live attenuated Salmonella enterica serovar Typhi-vectored vaccines. Vaccine 29(15):2761–2771Google Scholar
  110. Olin P, Gustafsson L, Barreto L, Hessel L, Mast TC, Rie AV, Bogaerts H, Storsaeter J (2003) Declining pertussis incidence in Sweden following the introduction of acellular pertussis vaccine. Vaccine 21(17–18):2015–2021PubMedGoogle Scholar
  111. Osorio M, Wu Y, Singh S, Merkel TJ, Bhattacharya SK, Blake MS, Kopecko OJ (2009) Anthrax protective antigen delivered by Salmonella enterica serovar Typhi Ty21a protects mice from a lethal anthrax spore challenge. Infect Immun 77(4):1475–1482Google Scholar
  112. Ottenhoff TH, Kaufmann SH (2012) Vaccines against tuberculosis: where are we and where do we need to go? PLoS Pathog 8(5):e1002607. doi: 10.1371/journal.ppat.1002607 PubMedCentralPubMedGoogle Scholar
  113. Pakkanen SH, Kantele JM, Kantele A (2012) Cross-reactive gut-directed immune response against Salmonella enterica serovar Paratyphi A and B in typhoid fever and after oral Ty21a typhoid vaccination. Vaccine 30(42):6047–6053PubMedGoogle Scholar
  114. Pasetti MF, Simon JK, Sztein MB, Levine MM (2011) Immunology of gut mucosal vaccines. Immunol Rev 239(1):125–148PubMedCentralPubMedGoogle Scholar
  115. Paz S, Broza M (2007) WInd direction and its linkage with Vibrio cholerae dissemination. Environ Health Perspect 115:195–200Google Scholar
  116. Perez E, Samper S, Bordas Y, Guilhot C, Gicquel B, Martin C (2001) An essential role for phoP in Mycobacterium tuberculosis virulence. Mol Microbiol 41(1):179–187PubMedGoogle Scholar
  117. Pichichero ME, Treanor J (1997) Economic impact of pertussis. Arch Pediatr Adolesc Med 151(1):35–40PubMedGoogle Scholar
  118. Pittman M (1991) History of the development of pertussis vaccine. Dev Biol Stand 73:13–29PubMedGoogle Scholar
  119. Pollard R (1980) Relation between vaccination and notification rates for whooping cough in England and Wales. Lancet 1(8179):1180–1182PubMedGoogle Scholar
  120. Poolman JT, Hallander H, Halperin SA (2011) Pertussis vaccines: where to now? Expert Rev Vaccines 10(11):1497–1500. doi: 10.1586/erv.11.147 PubMedGoogle Scholar
  121. Pulickal AS, Gautam S, Clutterbuck EA, Thorson S, Basynat B, Adhikari N, Makepeace K, Rijpkema S, Borrow R, Farrar JJ, Pollard AJ (2009) Kinetics of the natural, humoral immune response to Salmonella enterica serovar Typhi in Kathmandu, Nepal. Clin Vaccine Immunol 16(10):1413–1419PubMedCentralPubMedGoogle Scholar
  122. Qualls JE, Neale G, Smith AM, Koo MS, DeFreitas AA, Zhang H, Kaplan G, Watowich SS, Murray PJ (2010) Arginine usage in mycobacteria-infected macrophages depends on autocrine-paracrine cytokine signaling. Sci Signal 3(135):ra62. doi: 10.1126/scisignal.2000955
  123. Quiambao B, Van Der Meeren O, Kolhe D, Gatchalian S (2012) A randomized, dose-ranging assessment of the immunogenicity and safety of a booster dose of a combined diphtheria-tetanus-whole cell pertussis-hepatitis B-inactivated poliovirus-Hemophilus influenzae type b (DTPw-HBV-IPV/Hib) vaccine vs. co-administration of DTPw-HBV/Hib and IPV vaccines in 12 to 24 months old Filipino toddlers. Hum Vaccin Immunother 8(3):347–354. doi: 10.4161/hv.18630
  124. Richie EE, Punjabi NH, Sidharta YY, Peetosutan KK, Sukandar MM, Wasserman SS, Lesmana MM, Wangsasaputra FF, Pandam SS, Levine MM, O’Hanley PP, Cryz SJ, Simanjuntak CH (2000) Efficacy trial of single-dose live oral cholera vaccine CVD 103-HgR in North Jakarta, Indonesia, a cholera-endemic area. Vaccine 18(22):2399–2410PubMedGoogle Scholar
  125. Ritz N, Hanekom WA, Robins-Browne R, Britton WJ, Curtis N (2008) Influence of BCG vaccine strain on the immune response and protection against tuberculosis. FEMS Microbiol Rev 32(5):821–841. doi: 10.1111/j.1574-6976.2008.00118.x PubMedGoogle Scholar
  126. Rivera IN, Souza KM, Souza CP, Lopes RM (2012) Free-living and plankton-associated Vibrios: assessment in ballast water, harbor areas, and coastal ecosystems in Brazil. Front Microbiol 3:443PubMedCentralPubMedGoogle Scholar
  127. Robbins G, Tripathy VM, Misra VN, Mohanty RK, Shinde VS, Gray KM, Schug MD (2009) Ancient skeletal evidence for leprosy in India (2000 B.C.). PLoS ONE 4(5):e5669. doi: 10.1371/journal.pone.0005669 PubMedCentralPubMedGoogle Scholar
  128. Roland KL, Cloninger C, Kochi SK, Thomas LJ, Tinge SA, Rouskey C, Killeen KP (2007) Construction and preclinical evaluation of recombinant Peru-15 expressing high levels of the cholera toxin B subunit as a vaccine against enterotoxigenic Escherichia coli. Vaccine 25(51):8574–8584PubMedGoogle Scholar
  129. Roth A, Gustafson P, Nhaga A, Djana Q, Poulsen A, Garly ML, Jensen H, Sodemann M, Rodriques A, Aaby P (2005) BCG vaccination scar associated with better childhood survival in Guinea-Bissau. Int J Epidemiol 34(3):540–547. doi: 10.1093/ije/dyh392 PubMedGoogle Scholar
  130. Roth AE, Stensballe LG, Garly ML, Aaby P (2006) Beneficial non-targeted effects of BCG–ethical implications for the coming introduction of new TB vaccines. Tuberculosis (Edinb) 86(6):397–403. doi: 10.1016/j.tube.2006.02.001 Google Scholar
  131. Rumke HC, Schlumberger M, Floury B, Nagel J, van Steenis B (1993) Serological evaluation of a simplified immunization schedule using quadruple DPT-polio vaccine in Burkina Faso. Vaccine 11(11):1113–1118PubMedGoogle Scholar
  132. Ryan M, Murphy G, Ryan E, Nilsson L, Shackley F, Gothefors L, Oymar K, Miller E, Storsaeter J, Mills KH (1998) Distinct T-cell subtypes induced with whole cell and acellular pertussis vaccines in children. Immunology 93(1):1–10PubMedCentralPubMedGoogle Scholar
  133. Salmaso S, Mastrantonio P, Tozzi AE, Stefanelli P, Anemona A, Ciofi degli Atti ML, Giammanco A, Stage IIIWG (2001) Sustained efficacy during the first 6 years of life of 3-component acellular pertussis vaccines administered in infancy: the Italian experience. Pediatrics 108(5):E81Google Scholar
  134. Sambandamurthy VK, Derrick SC, Hsu T, Chen B, Larsen MH, Jalapathy KV, Chen M, Kim J, Porcelli SA, Chan J, Morris SL, Jacobs WR Jr (2006) Mycobacterium tuberculosis DeltaRD1 DeltapanCD: a safe and limited replicating mutant strain that protects immunocompetent and immunocompromised mice against experimental tuberculosis. Vaccine 24(37–39):6309–6320. doi: 10.1016/j.vaccine.2006.05.097 PubMedGoogle Scholar
  135. Sambandamurthy VK, Derrick SC, Jalapathy KV, Chen B, Russell RG, Morris SL, Jacobs WR Jr (2005) Long-term protection against tuberculosis following vaccination with a severely attenuated double lysine and pantothenate auxotroph of Mycobacterium tuberculosis. Infect Immun 73(2):1196–1203. doi: 10.1128/IAI.73.2.1196-1203.2005 PubMedCentralPubMedGoogle Scholar
  136. Sanchez J, Holmgren J (1989) Recombinant system for overexpression of cholera toxin B subunit in Vibrio cholerae as a basis for vaccine development. Proc Natl Acad Sci USA 86(2):481–485PubMedCentralPubMedGoogle Scholar
  137. Sato H, Sato Y (1999a) Experience with diphtheria toxoid-tetanus toxoid-acellular pertussis vaccine in Japan. Clin Infect Dis 28(Suppl 2):S124–S130. doi: 10.1086/515063 PubMedGoogle Scholar
  138. Sato Y, Sato H (1999b) Development of acellular pertussis vaccines. Biologicals 27(2):61–69. doi: 10.1006/biol.1999.0181 PubMedGoogle Scholar
  139. Sawyer LA, McInnis J, Patel A, Horne AD, Albrecht P (1994) Deleterious effect of thimerosal on the potency of inactivated poliovirus vaccine. Vaccine 12(9):851–856PubMedGoogle Scholar
  140. Schluger NW (2001) Recent advances in our understanding of human host responses to tuberculosis. Respir Res 2(3):157–163PubMedCentralPubMedGoogle Scholar
  141. Sester M, Sotgiu G, Lange C, Giehl C, Girardi E, Migliori GB, Bossink A, Dheda K, Diel R, Dominguez J, Lipman M, Nemeth J, Ravn P, Winkler S, Huitric E, Sandgren A, Manissero D (2011) Interferon-gamma release assays for the diagnosis of active tuberculosis: a systematic review and meta-analysis. Eur Respir J 37(1):100–111. doi: 10.1183/09031936.00114810 PubMedGoogle Scholar
  142. Sheridan SL, Ware RS, Grimwood K, Lambert SB (2012) Number and order of whole cell pertussis vaccines in infancy and disease protection. JAMA 308(5):454–456. doi: 10.1001/jama.2012.6364 PubMedGoogle Scholar
  143. Silva Miranda M, Breiman A, Allain S, Deknuydt F, Altare F (2012) The tuberculous granuloma: an unsuccessful host defence mechanism providing a safety shelter for the bacteria? Clin Dev Immunol 2012:139127. doi: 10.1155/2012/139127 PubMedCentralPubMedGoogle Scholar
  144. Simanjuntak CH, O’Hanley P, Punjabi NH, Noriega F, Pazzaglia G, Dykstra P, Kay B, Suharyono, Budiarso A, Rifai AR, et al. (1993) Safety, immunogenicity, and transmissibility of single-dose live oral cholera vaccine strain CVD 103-HgR in 24- to 59-month-old Indonesian children. J Infect Dis 168(5):1169–1176Google Scholar
  145. Simon R, Tennant SM, Galen JE, Levine MM (2011) Mouse models to assess the efficacy of non-typhoidal Salmonella vaccines: revisiting the role of host innate susceptibility and routes of challenge. Vaccine 29(32):5094–5106PubMedCentralPubMedGoogle Scholar
  146. Skerry CM, Cassidy JP, English K, Feunou-Feunou P, Locht C, Mahon BP (2009) A live attenuated Bordetella pertussis candidate vaccine does not cause disseminating infection in gamma interferon receptor knockout mice. Clin Vaccine Immunol 16(9):1344–1351. doi: 10.1128/CVI.00082-09 PubMedCentralPubMedGoogle Scholar
  147. Skowronski DM, De Serres G, MacDonald D, Wu W, Shaw C, Macnabb J, Champagne S, Patrick DM, Halperin SA (2002) The changing age and seasonal profile of pertussis in Canada. J Infect Dis 185(10):1448–1453. doi: 10.1086/340280 PubMedGoogle Scholar
  148. Steinhoff MC, Reed GF, Decker MD, Edwards KM, Englund JA, Pichichero ME, Rennels MB, Anderson EL, Deloria MA, Meade BD (1995) A randomized comparison of reactogenicity and immunogenicity of two whole-cell pertussis vaccines. Pediatrics 96(3 Pt 2):567–570PubMedGoogle Scholar
  149. Stojanov S, Liese J, Belohradsky BH (2000) Hospitalization and complications in children under 2 years of age with Bordetella pertussis infection. Infection 28(2):106–110PubMedGoogle Scholar
  150. Storsaeter J, Wolter J (2006) Is there a need for a new generation of vaccines against pertussis? Expert Opin Emerg Drugs 11(2):195–205. doi: 10.1517/14728214.11.2.195 PubMedGoogle Scholar
  151. Storsaeter J, Wolter J, Locht C (2007) Pertussis vaccines. In: Locht C (ed) Bordetella molecular microbiology. Horizon Bioscience, UKGoogle Scholar
  152. Sun R, Skeiky YA, Izzo A, Dheenadhayalan V, Imam Z, Penn E, Stagliano K, Haddock S, Mueller S, Fulkerson J, Scanga C, Grover A, Derrick SC, Morris S, Hone DM, Horwitz MA, Kaufmann SH, Sadoff JC (2009) Novel recombinant BCG expressing perfringolysin O and the over-expression of key immunodominant antigens; pre-clinical characterization, safety and protection against challenge with Mycobacterium tuberculosis. Vaccine 27(33):4412–4423. doi: 10.1016/j.vaccine.2009.05.048 PubMedGoogle Scholar
  153. Sur D, Kanungo S, Sah B, Manna B, Ali M, Paisley AM, Niyogi SK, Park JK, Sarkar B, Puri MK, Kim DR, Deen JL, Holmgren J, Carbis R, Rao R, Nguyen TV, Han SH, Attridge S, Donner A, Ganguly NK, Bhattacharya SK, Nair GB, Clemens JD, Lopez AL (2011) Efficacy of a low-cost, inactivated whole-cell oral cholera vaccine: results from 3 years of follow-up of a randomized, controlled trial. PLoS Negl Trop Dis 5(10):e1289PubMedCentralPubMedGoogle Scholar
  154. Sutherland I, Lindgren I (1979) The protective effect of BCG vaccination as indicated by autopsy studies. Tubercle 60(4):225–231PubMedGoogle Scholar
  155. Svennerholm AM (2011) From cholera to enterotoxigenic Escherichia coli (ETEC) vaccine development. Indian J Med Res 133:188–196PubMedCentralPubMedGoogle Scholar
  156. Svennerholm AM, Holmgren J (1976) Synergistic protective effect in rabbits of immunization with Vibrio cholerae lipopolysaccharide and toxin/toxoid. Infect Immun 13(3):735–740PubMedCentralPubMedGoogle Scholar
  157. Sweeney KA, Dao DN, Goldberg MF, Hsu T, Venkataswamy MM, Henao-Tamayo M, Ordway D, Sellers RS, Jain P, Chen B, Chen M, Kim J, Lukose R, Chan J, Orme IM, Porcelli SA, Jacobs WR Jr (2011) A recombinant Mycobacterium smegmatis induces potent bactericidal immunity against Mycobacterium tuberculosis. Nat Med 17(10):1261–1268. doi: 10.1038/nm.2420 PubMedCentralPubMedGoogle Scholar
  158. Tacket CO, Cohen MB, Wasserman SS, Losonsky G, Livio S, Kotloff K, Edelman R, Kaper JB, Cryz SJ, Giannella RA, Schiff G, Levine MM (1999) Randomized, double-blind, placebo-controlled, multicentered trial of the efficacy of a single dose of live oral cholera vaccine CVD 103-HgR in preventing cholera following challenge with Vibrio cholerae O1 El tor inaba three months after vaccination. Infect Immun 67(12):6341–6345PubMedCentralPubMedGoogle Scholar
  159. Tacket CO, Levine MM (2007) CVD 908, CVD 908-htrA, and CVD 909 live oral typhoid vaccines: a logical progression. Clin Infect Dis 45(Suppl 1):S20–S23PubMedGoogle Scholar
  160. Tennant SM, Wang JY, Galen JE, Simon R, Pasetti MF, Gat O, Levine MM (2011) Engineering and preclinical evaluation of attenuated nontyphoidal Salmonella strains serving as live oral vaccines and as reagent strains. Infect Immun 79(10):4175–4185PubMedCentralPubMedGoogle Scholar
  161. Therre H, Baron S (2000) Pertussis immunisation in Europe—the situation in late 1999. Euro Surveill 5(1):6–10PubMedGoogle Scholar
  162. Tomovasu T, Ohkishi T, Ukyo Y, Tokumitsu A, Takaya A, Suzuki M, Sekiya K, Matsui H, Kutsukake K, Yomamoto T (2002) The ClpX ATP-dependent protease regulates flagellum synthesis in Salmonella enterica serovar Typhimurium. J Bacteriol 184(3):645–653Google Scholar
  163. Tran TH, Nguyen TD, Nguyen TT, Ninh TT, Tran NB, Nguyen VM, Tran TT, Cao TT, Pham VM, Nguyen TC, Tran TD, Pham VT, To SD, Campbell JI, Stockwell E, Schultsz C, Simmons CP, Glover C, Lam W, Marques F, May JP, Upton A, Budhram R, Dougan G, Farrar J, Nguyen VV, Dolecek C (2010) A randomised trial evaluating the safety and immunogenicity of the novel single oral dose typhoid vaccine M01ZH09 in healthy Vietnamese children. PLoS ONE 5(7):e11778PubMedGoogle Scholar
  164. Trunz BB, Fine P, Dye C (2006) Effect of BCG vaccination on childhood tuberculous meningitis and miliary tuberculosis worldwide: a meta-analysis and assessment of cost-effectiveness. Lancet 367(9517):1173–1180. doi: 10.1016/S0140-6736(06)68507-3 PubMedGoogle Scholar
  165. Vekemans J, Amedei A, Ota MO, D’Elios MM, Goetghebuer T, Ismaili J, Newport MJ, Del Prete G, Goldman M, McAdam KP, Marchant A (2001) Neonatal bacillus Calmette-Guerin vaccination induces adult-like IFN-gamma production by CD4+ T lymphocytes. Eur J Immunol 31(5):1531–1535. doi: 10.1002/1521-4141(200105)31:5<1531:AID-IMMU1531>3.0.CO;2-1 PubMedGoogle Scholar
  166. Venkataswamy MM, Goldberg MF, Baena A, Chan J, Jacobs WR Jr, Porcelli SA (2012) In vitro culture medium influences the vaccine efficacy of Mycobacterium bovis BCG. Vaccine 30(6):1038–1049. doi: 10.1016/j.vaccine.2011.12.044 PubMedCentralPubMedGoogle Scholar
  167. Verreck FA, Vervenne RA, Kondova I, van Kralingen KW, Remarque EJ, Braskamp G, van der Werff NM, Kersbergen A, Ottenhoff TH, Heidt PJ, Gilbert SC, Gicquel B, Hill AV, Martin C, McShane H, Thomas AW (2009) MVA.85A boosting of BCG and an attenuated, phoP deficient M. tuberculosis vaccine both show protective efficacy against tuberculosis in rhesus macaques. PLoS ONE 4(4):e5264. doi: 10.1371/journal.pone.0005264 PubMedCentralPubMedGoogle Scholar
  168. Vogel FR, Leclerc C, Schutze MP, Jolivet M, Audibert F, Klein TW, Chedid L (1987) Modulation of carrier-induced epitopic suppression by Bordetella pertussis components and muramyl peptide. Cell Immunol 107(1):40–51PubMedGoogle Scholar
  169. von Konig CH, Halperin S, Riffelmann M, Guiso N (2002) Pertussis of adults and infants. Lancet Infect Dis 2(12):744–750Google Scholar
  170. von Reyn CF, Mtei L, Arbeit RD, Waddell R, Cole B, Mackenzie T, Matee M, Bakari M, Tvaroha S, Adams LV, Horsburgh CR, Pallangyo K, DarDar Study G (2010) Prevention of tuberculosis in bacille Calmette-Guerin-primed, HIV-infected adults boosted with an inactivated whole-cell mycobacterial vaccine. AIDS 24(5):675–685. doi: 10.1097/QAD.0b013e3283350f1b
  171. Wahid R, Pasetti MF, Maciel M Jr, Simon JK, Tacket CO, Levine MM, Sztein MB (2011) Oral priming with Salmonella typhi vaccine strain CVD 909 followed by parenteral boost with the S. typhi Vi capsular polysaccharide vaccine induces CD27+ IgD-S. typhi-specific IgA and IgG B memory cells in humans. Clin Immunol 138(2):187–200Google Scholar
  172. Wahid R, Simon R, Zafar SJ, Levine MM, Sztein MB (2012) Live oral typhoid vaccine Ty21a induces cross-reactive humoral immune responses against Salmonella enterica serovar Paratyphi A and S. paratyphi B in humans. Clin Vaccine Immunol 19(6):825–834PubMedCentralPubMedGoogle Scholar
  173. Walker AM, Jick H, Perera DR, Knauss TA, Thompson RS (1988) Neurologic events following diphtheria-tetanus-pertussis immunization. Pediatrics 81(3):345–349PubMedGoogle Scholar
  174. Walker V, Selby G, Wacogne I (2006) Does neonatal BCG vaccination protect against tuberculous meningitis? Arch Dis Child 91(9):789–791. doi: 10.1136/adc.2006.098459 PubMedCentralPubMedGoogle Scholar
  175. Wang JY, Pasetti MF, Noriega FR, Anderson RJ, S.S. W, Galen JE, Sztein MB, Levine MM (2001) Construction, genotypic and phenotypic characterization, and immunogenciity of attenated DeltaguaBA Salmonella enterica serover Typhi strain CVD 915. Infect Immun 69(8):4734–4741Google Scholar
  176. Watkins ML, Semple PL, Abel B, Hanekom WA, Kaplan G, Ress SR (2008) Exposure of cord blood to Mycobacterium bovis BCG induces an innate response but not a T-cell cytokine response. Clin Vaccine Immunol 15(11):1666–1673. doi: 10.1128/CVI.00202-08 PubMedCentralPubMedGoogle Scholar
  177. Weingart CL, Keitel WA, Edwards KM, Weiss AA (2000) Characterization of bactericidal immune responses following vaccination with acellular pertussis vaccines in adults. Infect Immun 68(12):7175–7179PubMedCentralPubMedGoogle Scholar
  178. Wendelboe AM, Van Rie A, Salmaso S, Englund JA (2005) Duration of immunity against pertussis after natural infection or vaccination. Pediatr Infect Dis J 24(5 Suppl):S58–S61PubMedGoogle Scholar
  179. Winter K, Harriman K, Zipprich J, Schechter R, Talarico J, Watt J, Chavez G (2012) California pertussis epidemic, 2010. J Pediatr. doi: 10.1016/j.jpeds.2012.05.041 PubMedGoogle Scholar
  180. Witt MA, Katz PH, Witt DJ (2012) Unexpectedly limited durability of immunity following acellular pertussis vaccination in preadolescents in a North American outbreak. Clin Infect Dis 54(12):1730–1735. doi: 10.1093/cid/cis287 PubMedGoogle Scholar
  181. Woodworth JS, Wu Y, Behar SM (2008) Mycobacterium tuberculosis-specific CD8+ T cells require perforin to kill target cells and provide protection in vivo. J Immunol 181(12):8595–8603PubMedCentralPubMedGoogle Scholar
  182. World Health Organization (2001) Cholera vaccines. WHO position paper. WHO Wkly Epidemiol Rec 76(16):117–124Google Scholar
  183. World Health Organization (2004) BCG vaccine. WHO position paper. Wkly Epidemiol Rec 79(4):27–38Google Scholar
  184. World Health Organization (2005) Pertussis vaccines–WHO position paper. Wkly Epidemiol Rec 80(4):31–39Google Scholar
  185. World Health Organization (2010) Global Advisory Committee on vaccine safety, 3–4 December 2009. Wkly Epidemiol Rec 85(5):29–33Google Scholar
  186. World Health Organization (2011) TB/HIV Facts 2011–2012. http://www.who.int/tb/publications/TBHIV_Facts_for_2011.pdf
  187. World Health Organization (2012a) Global tuberculosis report, 2012Google Scholar
  188. World Health Organization (2012b) Immunization summary: a statistical reference containing data through 2010Google Scholar
  189. World Health Organization (2012c) WHO prequalified vaccines. In: Immunization Standards. World Health Organization. http://www.who.int/immunization_standards/vaccine_quality/PQ_vaccine_list_en/en/index.html
  190. World Health Organization (2012d) WHO Technical Working Group on creation of an oral cholera vaccine stockpile. In: Diseases PaE (ed) Meeting report, 26–27 April 2012. WHO, GenevaGoogle Scholar
  191. Xu DQ, Zhang L, Kopecko DJ, Gao L, Shao Y, Guo B et al (2009) Bacterial delivery of siRNAs: a new approach to solid tumor therapy. Methods Mol Biol 487:161–187Google Scholar
  192. Yang XY, Chen QF, Li YP, Wu SM (2011) Mycobacterium vaccae as adjuvant therapy to anti-tuberculosis chemotherapy in never-treated tuberculosis patients: a meta-analysis. PLoS ONE 6(9):e23826. doi: 10.1371/journal.pone.0023826 PubMedCentralPubMedGoogle Scholar
  193. Zepp F, Heininger U, Mertsola J, Bernatowska E, Guiso N, Roord J, Tozzi AE, Van Damme P (2011) Rationale for pertussis booster vaccination throughout life in Europe. Lancet Infect Dis 11(7):557–570. doi: 10.1016/S1473-3099(11)70007-X PubMedGoogle Scholar
  194. Zhang L, Prietsch SO, Axelsson I, Halperin SA (2011) Acellular vaccines for preventing whooping cough in children. Cochrane Database Syst Rev 1:CD001478Google Scholar
  195. Zhang L, Prietsch SO, Axelsson I, Halperin SA (2012) Acellular vaccines for preventing whooping cough in children. Cochrane Database Syst Rev 3:CD001478. doi: 10.1002/14651858.CD001478.pub5
  196. Zhou L, Pollard AJ (2010) A fast and highly sensitive blood culture PCR method for clinical detection of Salmonella enterica serovar Typhi. Ann Clin Microbiol Antimicrob 9:14PubMedCentralPubMedGoogle Scholar
  197. Zorlu G (2012) Cholera vaccine deployed to control African outbreak. Nature 486(7402):157–286Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Anita H. J. van den Biggelaar
    • 1
  • Jan T. Poolman
    • 1
    Email author
  1. 1.Bacterial Vaccines—Discovery and Early DevelopmentLeidenThe Netherlands

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