Abstract
Anterior lamellar keratoplasty (ALK) is a corneal transplant procedure where diseased anterior corneal stroma is selectively replaced with donor stromal tissue while preserving the host Descemet’s membrane and endothelium. Despite ALK’s longer history, the most commonly performed procedure for the last 100 years has been PKP, and this has been attributed to the technical difficulties in achieving a successful ALK. However, over the past two decades, improvements in surgical instrumentation and techniques, including the femtosecond laser, have caused resurgence in interest in anterior lamellar corneal surgery.
ALK can be subcategorized as superficial anterior lamellar keratoplasty (sALK), for the treatment of stromal pathology usually involving the anterior 200–250 μm, and deep anterior lamellar keratoplasty (DALK) for the treatment of deeper stromal pathology. The most common techniques for performing each are described in this chapter. For sALK we discuss in detail manual dissection, microkeratome-assisted ALK, and sutureless femtosecond laser-assisted anterior lamellar keratoplasty (FALK) with emphasis on steps in performing the procedures, complications, and outcomes. Similarly, we describe common DALK procedures with extra focus on manual dissection (open dissection), Melles technique (closed dissection), Anwar’s big-bubble technique, and femtosecond laser-assisted techniques. Finally general considerations and possible complications are described with insight on management options and follow-up care.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Anwar M. Dissection technique in lamellar keratoplasty. Br J Ophthalmol. 1972;56:711–3.
Anwar M, Teichmann KD. Big-bubble technique to bare descemet’s membrane in anterior lamellar keratoplasty. J Cataract Refract Surg. 2002a;28:398–403.
Anwar M, Teichmann KD. Deep lamellar keratoplasty: surgical techniques for anterior lamellar keratoplasty with and without baring of Descemet’s membrane. Cornea. 2002b;21:374–83.
Archila EA. Deep lamellar keratoplasty dissection of host tissue with intrastromal air injection. Cornea. 1984;3:217–8.
Baradaran-Rafii A, Eslani M, Sadoughi M-M, Esfandiari H, Karimian F. Anwar versus Melles deep anterior lamellar keratoplasty for keratoconus: a prospective randomized clinical trial. Ophthalmology. 2013;120:252–9.
Borderie VM, Sandali O, Bullet J, Gaujoux T, Touzeau O, Laroche L. Long-term results of deep anterior lamellar versus penetrating keratoplasty. Ophthalmology. 2012;119:249–55.
Busin M. Microkeratome-assisted superficial anterior lamellar keratoplasty. Tech Ophthalmol. 2006;4:64–8.
Buzzonetti L, Laborante A, Petrocelli G. Refractive outcome of keratoconus treated by combined femtosecond laser and big-bubble deep anterior lamellar keratoplasty. J Refract Surg. 2011;27:189–94.
Chamberlain W, Cabezas M. Femtosecond-assisted deep anterior lamellar keratoplasty using big-bubble technique in a cornea with 16 radial keratotomy incisions. Cornea. 2011;30:233–6.
Chan CC, Ritenour RJ, Kumar NL, Sansanayudh W, Rootman DS. Femtosecond laser-assisted mushroom configuration deep anterior lamellar keratoplasty. Cornea. 2010;29:290–5.
Chau GK, Dilly SA, Sheard CE, Rostron CK. Deep lamellar keratoplasty on air with lyophilised tissue. Br J Ophthalmol. 1992;76:646–50.
Farid M, Steinert RF. Deep anterior lamellar keratoplasty performed with the femtosecond laser zigzag incision for the treatment of stromal corneal pathology and ectatic disease. J Cataract Refract Surg. 2009;35:809–13. doi:10.1016/j.jcrs.2009.01.012.
Fogla R. Deep anterior lamellar keratoplasty in the management of keratoconus. Indian J Ophthalmol. 2013;61:465–8.
Fogla R, Padmanabhan P. Results of deep lamellar keratoplasty using the big-bubble technique in patients with keratoconus. Am J Ophthalmol. 2006;141:254–9.
Funnell CL, Ball J, Noble BA. Comparative cohort study of the outcomes of deep lamellar keratoplasty and penetrating keratoplasty for keratoconus. Eye (Lond). 2006;20:527–32.
FX Mühlbauer: Ueber Trasnplasntation der Cornea (Gekronte Preisschrift, Jos. Lindaauer, Mucich 1840). CC Schmidt Jahrbücher der in- und ausländischen gesammten Medicin. 1842 Otto Weigand Leipzig. p. 267–88, n.d.
Karabela Y, Muftuoglu O, Gulkilik IG, Kocabora MS, Ozsutcu M. Intraoperative and early postoperative flap-related complications of laser in situ keratomileusis using two types of Moria microkeratomes. Int Ophthalmol. 2014;34:1107–14.
Leccisotti A. Descemet’s membrane perforation during deep anterior lamellar keratoplasty: prognosis. J Cataract Refract Surg. 2007;33:825–9.
Lim LS, Aung HT, Aung T, Tan DTH. Corneal imaging with anterior segment optical coherence tomography for lamellar keratoplasty procedures. Am J Ophthalmol. 2008;145:81–90.
Maurino V, Allan BDS, Stevens JD, Tuft SJ. Fixed dilated pupil (Urrets-Zavalia syndrome) after air/gas injection after deep lamellar keratoplasty for keratoconus. Am J Ophthalmol. 2002;133:266–8.
Melles GR, Lander F, Rietveld FJ, Remeijer L, Beekhuis WH, Binder PS. A new surgical technique for deep stromal, anterior lamellar keratoplasty. Br J Ophthalmol. 1999;83:327–33.
Melles GR, Remeijer L, Geerards AJ, Beekhuis WH. A quick surgical technique for deep, anterior lamellar keratoplasty using visco-dissection. Cornea. 2000;19:427–32.
Mosca L, Fasciani R, Mosca L, Guccione L, Legrottaglie EF, Siniscalco A, Riso M, Balestrazzi E. Graft rejection after femtosecond laser–assisted deep anterior lamellar keratoplasty: report of 3 cases. Cornea. 2011;30:912–6.
Mosca L, Fasciani R, Tamburelli C, Buzzonetti L, Guccione L, Mandarà E, Balestrazzi E. Femtosecond laser-assisted lamellar keratoplasty: early results. Cornea. 2008;27:668–72.
Patel AK, Scorcia V, Kadyan A, Lapenna L, Ponzin D, Busin M. Microkeratome-assisted superficial anterior lamellar keratoplasty for anterior stromal corneal opacities after penetrating keratoplasty. Cornea. 2012;31:101–5.
Price FW, Price MO, Grandin JC, Kwon R. Deep anterior lamellar keratoplasty with femtosecond-laser zigzag incisions. J Cataract Refract Surg. 2009;35:804–8.
Ramamurthi S, Ramaesh K. Surgical management of healed hydrops: a novel modification of deep anterior lamellar keratoplasty. Cornea. 2011;30:180–3.
Reisinger F. Die Keratoplastik: ein Versuch zur Erweiterung der Augenheil kunst. Bayer Ann. 1824;1:207–15.
Sharma N, Kumar C, Mannan R, Titiyal JS, Vajpayee RB. Surgical technique of deep anterior lamellar keratoplasty in descemetoceles. Cornea. 2010;29:1448–51.
Shehadeh-Mashor R, Chan CC, Bahar I, Lichtinger A, Yeung SN, Rootman DS. Comparison between femtosecond laser mushroom configuration and manual trephine straight-edge configuration deep anterior lamellar keratoplasty. Br J Ophthalmol. 2014;98:35–9.
Shimazaki J, Shimmura S, Ishioka M, Tsubota K. Randomized clinical trial of deep lamellar keratoplasty vs penetrating keratoplasty. Am J Ophthalmol. 2002;134:159–65.
Shousha MA, Yoo SH. New therapeutic modalities in femtosecond laser-assisted corneal surgery. Int Ophthalmol Clin. 2010;50:149–60.
Shousha MA, Yoo SH, Kymionis GD, Ide T, Feuer W, Karp CL, O’Brien TP, Culbertson WW, Alfonso E. Long-term results of femtosecond laser-assisted sutureless anterior lamellar keratoplasty. Ophthalmology. 2011;118:315–23.
Sugita J, Kondo J. Deep lamellar keratoplasty with complete removal of pathological stroma for vision improvement. Br J Ophthalmol. 1997;81:184–8.
Suwan-Apichon O, Reyes JMG, Griffin NB, Barker J, Gore P, Chuck RS. Microkeratome versus femtosecond laser predissection of corneal grafts for anterior and posterior lamellar keratoplasty. Cornea. 2006;25:966–8.
Von Hippel A. Eine neue methode der Hornhauttransplantation. Arch Ophthalmol. 1888;34:105–30.
Watson SL, Ramsay A, Dart JKG, Bunce C, Craig E. Comparison of deep lamellar keratoplasty and penetrating keratoplasty in patients with keratoconus. Ophthalmology. 2004;111:1676–82. doi:10.1016/j.ophtha.2004.02.010.
Yoo SH, Kymionis GD, Koreishi A, Ide T, Goldman D, Karp CL, O’Brien TP, Culbertson WW, Alfonso EC. Femtosecond laser-assisted sutureless anterior lamellar keratoplasty. Ophthalmology. 2008;115:1303–7, 1307.e1.
Zirm E. Eine erfolgreiche totale Keratoplastik. Graefes Arch Ophthalmol. 1906;64:580–93.
Compliance with Ethical Requirements
Conflict of Interest
Marwan Atallah and Guillermo Amescua declare that they have no conflict of interest.
Informed Consent
No human studies were carried out by the authors for this article.
Animal Studies
No animal studies were carried out by the authors for this article.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Atallah, M., Amescua, G. (2014). Advancements in Anterior Lamellar Keratoplasty. In: Jeng, B. (eds) Advances in Medical and Surgical Cornea. Essentials in Ophthalmology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-44888-5_7
Download citation
DOI: https://doi.org/10.1007/978-3-662-44888-5_7
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-44887-8
Online ISBN: 978-3-662-44888-5
eBook Packages: MedicineMedicine (R0)