Skip to main content
SpringerLink
Log in

Nuclear Medicine Imaging

  • Chapter
  • First Online:
Pitfalls in Diagnostic Radiology

  • 2681 Accesses

Abstract

Currently, nuclear medicine imaging provides both functional/molecular and structural information, derived from a combination of different scientific techniques in radiochemical/radiopharmaceutical labeling, imaging technology, and image reconstruction methodologies as well as a good understanding of physiology and molecular biology and a sound approach to clinical interpretation. Pitfalls in nuclear medicine imaging fall into the following three main categories: (1) radioisotope or radiotracer; (2) scanning techniques, procedure, or scanner hardware or software; and (3) clinical, relating to patient factors and interpretation of scans. Various pitfalls from each category are described. Reducing artifacts arising from these three categories is key to the correct performance and interpretation of nuclear medicine studies.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 149.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

DTPA:

Diethylenetriaminepentaacetic acid

ECG:

Electrocardiogram

FDG:

F-18 fluorodeoxyglucose

MAA:

Macroaggregated albumin

MDP:

Methylene diphosphonate

MIBG:

Metaiodobenzylguanidine

MUGA:

Multi-gated acquisition

PET:

Positron emission tomography

PET-CT:

PET computed tomography

PET-MRI:

PET magnetic resonance imaging

SPECT:

Single-photon emission computed tomography

SPECT-CT:

SPECT computed tomography

SUV:

Standardized uptake value

V/Q:

Ventilation-perfusion

References

  • Bamba Y, Itabashi M, Kameoka S (2011) Value of PET/CT imaging for diagnosing pulmonary metastasis of colorectal cancer. Hepatogastroenterology 58:1972–1974

    Article  PubMed  Google Scholar 

  • Bomardieri E, Giammarile F, Aktolun C et al (2010) 131I/123I Metaiodobenzylguanidine (mIBG) scintigraphy: procedure guidelines for tumor imaging. Eur J Nucl Med Mol Imaging 37:2436–2446

    Article  Google Scholar 

  • Bujenovic S, Mannting F, Chakrabarti R et al (2003) Artifactual 2-Deoxy-2-[18F]Fluoro-D-glucose localization surrounding metallic objects in a PET/CT scanner using CT-based attenuation correction. Mol Imaging Biol 5:20–22

    Article  PubMed  Google Scholar 

  • Cohade C, Osman M, Nakamoto Y et al (2003) Initial experience with oral contrast in PET/CT: phantom and clinical studies. J Nucl Med 44:412–416

    PubMed  Google Scholar 

  • Corbett JR, Akinboboye OO, Bacharach SL et al (2006) Equilibrium radionuclide angiography. J Nucl Cardiol 13:e56–e79

    Article  PubMed  Google Scholar 

  • Delbeke D, Coleman RE, Guiberteau MJ (2006) Procedure guideline for tumor imaging with 18F-FDG PET/CT 1.0. J Nucl Med 47:885–895

    PubMed  Google Scholar 

  • Gnanasegaran G, Cook G, Adamson K et al (2009) Patterns, variants, artifacts, and pitfalls in conventional radionuclide bone imaging and SPECT/CT. Semin Nucl Med 39:380–395

    Article  PubMed  Google Scholar 

  • Goerres GW, Kamel E, Seifert B et al (2002) Accuracy of image coregistration of pulmonary lesions in patients with non-small cell lung cancer using an integrated PET/CT system. J Nucl Med 43:1469–1475

    PubMed  Google Scholar 

  • Guerra L, De Ponti E, Elisei F et al (2012) Respiratory gated PET/CT in a European multicentre retrospective study: added diagnostic value in detection and characterization of lung lesions. Eur J Nucl Med Mol Imaging 39:1381–1390

    Article  PubMed  Google Scholar 

  • Hinton PJ, Clauss RP (2011) Dissociation of Tc-99m DTPA in a nebulizer. Nucl Med Comm 32:659–661

    Article  Google Scholar 

  • Kim SK, Kang KW, Lee JS et al (2006) Assessment of lymph node metastases using 18F-FDG PET in patients with advanced gastric cancer. Eur J Nucl Med Mol Imaging 33:148–155

    Article  PubMed  Google Scholar 

  • Mayerhoefer ME, Prosch H, Herold CJ et al (2012) Assessment of pulmonary melanoma metastases with 18F-FDG PET/CT: which PET-negative patients require additional tests for definitive staging? Eur Radiol 22:2451–2457

    Article  PubMed  Google Scholar 

  • Osman MM, Cohade C, Nakamoto Y et al (2003) Clinically significant inaccurate localization of lesions with PET/CT: frequency in 300 patients. J Nucl Med 44:240–243

    PubMed  Google Scholar 

  • Reinhardt MJ, Wiethoelter N, Matthies A et al (2006) PET recognition of pulmonary metastases on PET/CT imaging: impact of attenuation-corrected and non-attenuation corrected PET images. Eur J Nucl Med Mol Imaging 33:134–139

    Article  PubMed  Google Scholar 

  • Schoder H, Erdi YE, Chao K et al (2004) Clinical implications of different image reconstruction parameters for interpretation of whole-body PET studies in cancer patients. J Nucl Med 45:559–566

    PubMed  Google Scholar 

  • Thie JA (2004) Understanding the standardized uptake value, its methods and implications for usage. J Nucl Med 45:1431–1434

    PubMed  Google Scholar 

  • van Dalen JA, Vogel WV, Corstens FH et al (2007) Multi-modality nuclear medicine imaging: artefacts, pitfalls and recommendations. Cancer Imaging 7:77–83

    Article  PubMed Central  PubMed  Google Scholar 

  • Yoshioka T, Yamaguchi K, Kubota K et al (2003) Evaluation of 18F-FDG PET in patients with advanced, metastatic or recurrent gastric cancer. J Nucl Med 44:690–699

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Nuclear Medicine and PET, Singapore General Hospital, Outram Road, Singapore, 169608, Republic of Singapore

    David Chee Eng Ng MBBS, FRCP (Edin), Winnie Wing Chuen Lam MBBS, FRCR & Anthony Soon Whatt Goh MBBS, MSc (Nuclear Med)

Authors
  1. David Chee Eng Ng MBBS, FRCP (Edin)
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Winnie Wing Chuen Lam MBBS, FRCR
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Anthony Soon Whatt Goh MBBS, MSc (Nuclear Med)
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to David Chee Eng Ng MBBS, FRCP (Edin) .

Editor information

Editors and Affiliations

  1. Department of Diagnostic Radiology, Khoo Teck Puat Hospital, Alexandra Health, Singapore, Singapore

    Wilfred C. G. Peh

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Ng, D.C.E., Lam, W.W.C., Goh, A.S.W. (2015). Nuclear Medicine Imaging. In: Peh, W. (eds) Pitfalls in Diagnostic Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-44169-5_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-44169-5_4

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-44168-8

  • Online ISBN: 978-3-662-44169-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation