Everyday life relies heavily on the reliable operation and intelligent management of large-scale critical infrastructures, such as electric power systems, telecommunication networks, and water distribution networks. The design, monitoring, control and security of such systems are becoming increasingly more challenging as their size, complexity and interactions are steadily growing. Moreover, these critical infrastructures are susceptible to natural disasters, accidents, frequent failures, as well as malicious attacks. There is an urgent need to develop a common framework for modeling the behavior of critical infrastructure systems and for designing algorithms for intelligent monitoring, control and security of such systems. This book provides basic principles as well as new research directions for intelligent monitoring, control, and security of critical infrastructure systems, with an emphasis on electric power systems, telecommunication networks, water distribution systems, and transportation systems.