The Influence of Transcranial Micro-electric Current Physiological Training on Cerebral Function Under Altitude Hypoxia

Conference paper
Part of the Lecture Notes in Electrical Engineering book series (LNEE, volume 318)


Objective To investigate the effects of transcranial micro-electric current physiological training (TMCPT) on cerebral function (CF) in order to provide technology and methods for maintaining and training CF under altitude hypoxia. Methods Forty healthy volunteers served as subjects, who took flight to the altitude and were trained by TMCPT in the condition of altitude hypoxia (3,700 m above sea level). Current intensity of TMCPT was limited within safe physiological range. Subjects were trained twice per day (one in the morning and the other in the afternoon), each for 5 min. Neurobehavioral ability index was separately observed in rush entry phase (first 10 days after entry) and in various resident phases (resided in altitude for 1, 2, and 3 months). Self-evaluating questionnaire and Pittsburgh Sleep Quality Index were used to evaluate sleep quality in different phases. Results ① In rush entry phase: digital scan, memory scan, simple visual reaction time, complex visual reaction time, pursuit aiming and consecutive performance were significantly increased at 10 days after TMCPT training (t = 1.982–4.412, P < 0.05) as compared with those at 1 day. ② Resident phase: compared to neurobehavioral ability index at 1 month, only digital scan, memory scan and simple visual reaction time were significantly increased at 3 months after TMCPT (t = 3.744–5.812, P < 0.05) as compared with those at 1 month. ③ Sleep quality evaluation: sleep quality indexes had a significant reduction after TMCPT as compared with those in rush entry phase (t = 1.833–3.552, P < 0.05). Conclusions TMCPT can improve CF and sleep quality under altitude hypoxia. The β-frequency brain-wave feedback training can be used to promote CF, and α-frequency brain-wave feedback training can be utilized to improve sleep quality.


Altitude Hypoxia Brain Neurobehavioral manifestations 


  1. 1.
    Chen Y, Wang S (2012) The effects of altitude hypoxia on sleep and cerebral function. Med Air Force 8(3):150–158Google Scholar
  2. 2.
    Sampaio LA, Fraguas R, Lotufo PA et al (2012) A systematic review of non-invasive brain stimulation therapies and cardiovascular risk: implications for the treatment of major depressive disorder. Front Psychiatry 3(1):87–90Google Scholar
  3. 3.
    Motohashi N, Yamaguchi M, Fujii T et al (2013) Mood and cognitive function following repeated transcranial direct current stimulation in healthy volunteers: a preliminary report. Neurosci Res 77(1/2):64–69CrossRefGoogle Scholar
  4. 4.
    Miranda PC (2013) Physics of effects of transcranial brain stimulation. Handb Clin Neuro 116:353–366CrossRefGoogle Scholar
  5. 5.
    Stumbrys T, Erlacher D, Schredl M (2013) Testing the involvement of the prefrontal cortex in lucid dreaming: a tDCS study. Conscious Cogn 22(4):1214–1222CrossRefGoogle Scholar
  6. 6.
    Kaminski E, Hoff M, Sehm B et al (2013) Effect of transcranial direct current stimulation (tDCS) during complex whole body motor skill learning. Neurosci Lett 552:76–80CrossRefGoogle Scholar
  7. 7.
    Palm U, Fintescu Z, Obermeier M et al (2013) Serum levels of brain derived neurotrophic factor are unchanged after transcranial direct current stimulation in treatment resistant depression. J Affect Disord 150(2):659–663CrossRefGoogle Scholar
  8. 8.
    Alonzo A, Chan G, Martin D et al (2013) Transcranial direct current stimulation (tDCS) for depression: analysis of response using a three factor structure of the Montgomery asberg depression rating scale. J Affect Disord 150(1):91–95CrossRefGoogle Scholar
  9. 9.
    Hoy KE, Emonson MR, Arnold SL et al (2013) Testing the limits: Investigating the effect of tDCS dose on working memory enhancement in healthy controls. Neuropsychologia 51(9):1777–1784CrossRefGoogle Scholar
  10. 10.
    Brunoni AR, Ferrucci R, Bortolomasi M et al (2013) Interactions between transcranial direct current stimulation (tDCS) and pharmacological interventions in the major depressive episode: findings from a naturalistic study. Eur Psychiatry 28(6):356–361CrossRefGoogle Scholar
  11. 11.
    Javadi AH, Cheng P (2013) Transcranial direct current stimulation (tDCS) enhances reconsolidation of longterm memory. Brain Stimul 6(4):668–674CrossRefGoogle Scholar
  12. 12.
    Hauser TU, Rotzer S, Grabner RH et al (2013) Enhancing performance in numerical magnitude processing and mental arithmetic using transcranial direct current stimulation (tDCS). Front Hum Neurosci 7:244CrossRefGoogle Scholar
  13. 13.
    Lefebvre S, Laloux P, Peeters A et al (2013) Dualt DCS enhances online motor skill learning and longterm retention in chronic stroke patients. Front Hum Neurosci 6:343CrossRefGoogle Scholar
  14. 14.
    Herrmann CS, Rach S, Neuling T et al (2013) Transcranial alternating current stimulation: a review of the underlying mechanisms and modulation of cognitive processes. Front Hum Neurosci 7:279CrossRefGoogle Scholar
  15. 15.
    Pi X, Lu R, Shen Y (2005) Development of pulse therapeutic apparatus with biphasic constant current and measured electrode impedance. J Chin Med Equip 26(9):11–15Google Scholar
  16. 16.
    Yao D (2003) The electronic theory and method for brain detection. Scientific Press, Beijing, pp 1–200Google Scholar
  17. 17.
    Chen Y, Jia H, Deng X et al (2011) Application of neurobehavioral evaluation system for the identification of pilot`s cerebral function. Chin J Aerospace Med 22(1):22–25Google Scholar
  18. 18.
    YY 0505-2005/IEC60601-1-2 General safety requirements of medical instrument (2001) Medical Industrial Standard of People`s Republic of ChinaGoogle Scholar
  19. 19.
    Zaghi S, Acar M, Hultgren B et al (2010) Noninvasive brain stimulation with low intensity electrical currents: putative mechanisms of action for direct and alternating current stimulation. Neuroscientist 16(3):285–307CrossRefGoogle Scholar
  20. 20.
    Kuo HI, Bikson M, Datta A et al (2013) Comparing cortical plasticity induced by conventional and high definition 4 × 1 ring tDCS: a neurophysiological study. Brain Stimul 6(4):644–648CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Institute of Aviation Medicine, Air ForceBeijingChina

Personalised recommendations