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Apoptosis and Cancer

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Cancer Immunology

Abstract

Cancer is a worldwide endemic and continues to be one of the most difficult diseases to treat and manage, which may be due to the multifactorial nature of the disease. Cancer generally exhibits considerable genetic complexity and aberrant cell death and survival signaling pathways. Resistance to cell death induction has long been recognized as a hallmark of cancer. Therefore, increased understanding of the underlying molecular events regulating different cell death mechanisms such as apoptosis, necroptosis, and autophagy has provided new possibilities for targeted interference of these pathways. This chapter highlights the significant signaling pathways of apoptosis and the relevant therapeutic targets and summarizes the current state of development of specific modulators of cell death and the overall outcome of this group of novel therapeutics in various phases of clinical trials.

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Acknowledgments

The authors would like to acknowledge the Ministry of Science, Technology and Innovation Malaysia and Universiti Sains Malaysia.

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Authors and Affiliations

  1. Advanced Medical and Dental Institute, Universiti Sains Malaysia, Persiaran Seksyen 4/9, Bandar Putra Bertam, Kepala Batas, Pulau Pinang, 13200, Malaysia

    Mei Lan Tan PhD

  2. Malaysian Institute of Pharmaceuticals & Nutraceuticals, Ministry of Science, Technology & Innovation (MOSTI), Block 5A, Halaman Bukit Gambir, Minden, Pulau Pinang, 11700, Malaysia

    Mei Lan Tan PhD & Heng Kean Tan BSc (Hons)

  3. Institute of Marine Biotechnology, Universiti Malaysia Terengganu, Kuala Terengganu, 21030, Terengganu, Malaysia

    Tengku Sifzizul Tengku Muhammad PhD

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  1. Children's Medical Center Hospital, Tehran University of Medical Sciences Research Center for Immunodeficiencies, Tehran, Iran

    Nima Rezaei

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Tan, M.L., Tan, H.K., Muhammad, T.S.T. (2015). Apoptosis and Cancer. In: Rezaei, N. (eds) Cancer Immunology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-44006-3_13

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  • DOI: https://doi.org/10.1007/978-3-662-44006-3_13

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